All Phenotypes Sst<tm2.1(cre)Zjh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sst^{tm2.1(cre)Zjh}
targeted mutation 2.1, Z Josh Huang
MGI:4838416

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sst^{tm2.1(cre)Zjh}/Sst^{tm2.1(cre)Zjh}	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:4838419
cn2	Mecp2^tm1Bird/Y Sst^{tm2.1(cre)Zjh}/Sst⁺	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5749568
cn3	Ptchd1^tm2.1Gfng/Y Sst^{tm2.1(cre)Zjh}/Sst⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J	MGI:5792694
cn4	Eef1a1^tm1Klan/Eef1a1^tm1Klan Sst^{tm2.1(cre)Zjh}/Sst⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	MGI:6693446
cn5	Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg}/Col1a1⁺ Sst^{tm2.1(cre)Zjh}/Sst⁺	involves: 129S4/SvJae * C57BL/6J	MGI:6693445

Allelic Composition	Sst^{tm2.1(cre)Zjh}/Sst^{tm2.1(cre)Zjh}
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sst^{tm2.1(cre)Zjh} mutation (4 available); any Sst mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:151755 )

• homozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities

Allelic Composition	Mecp2^tm1Bird/Y Sst^{tm2.1(cre)Zjh}/Sst⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1Bird mutation (2 available); any Mecp2 mutation (38 available)
Sst^{tm2.1(cre)Zjh} mutation (4 available); any Sst mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:228740 )

• 50% mortality by 29-35 weeks of age

behavior/neurological

increased stereotypic behavior ( J:228740 )

• mice exhibit repetitive nose-poking behavior in the hole board test

• however, mice do not exhibit motor deficits or alternations in acoustic startle response, partition, or cued memory tests, or differences in anxiety, pre-pulse inhibition, locomotor activity or long-term potentiation

seizures ( J:228740 )

• 50% of mice develop spontaneous epileptic seizures starting at 12 weeks

tonic-clonic seizures ( J:228740 )

• mice show generalized tonic clonic seizures during routine handling

nervous system

seizures ( J:228740 )

• 50% of mice develop spontaneous epileptic seizures starting at 12 weeks

tonic-clonic seizures ( J:228740 )

• mice show generalized tonic clonic seizures during routine handling

Allelic Composition	Ptchd1^tm2.1Gfng/Y Sst^{tm2.1(cre)Zjh}/Sst⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptchd1^tm2.1Gfng mutation (1 available); any Ptchd1 mutation (9 available)
Sst^{tm2.1(cre)Zjh} mutation (4 available); any Sst mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:232709 )

N	• mice exhibit normal hypertonia and no hyper-aggression

abnormal cognition ( J:232709 )

• attention deficits as in knock-out mice

hyperactivity ( J:232709 )

fragmentation of sleep/wake states ( J:232709 )

• highly fragmented sleep

Allelic Composition	Eef1a1^tm1Klan/Eef1a1^tm1Klan Sst^{tm2.1(cre)Zjh}/Sst⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^tm1Klan mutation (1 available); any Eef1a1 mutation (60 available)
Sst^{tm2.1(cre)Zjh} mutation (4 available); any Sst mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:297390 )

• mice infusion with asunaprivir (drug inducer of iPKR) exhibit reduced memory in a cued threat-conditioning paradigm compared with wild-type

Allelic Composition	Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg}/Col1a1⁺ Sst^{tm2.1(cre)Zjh}/Sst⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg} mutation (0 available); any Col1a1 mutation (160 available)
Sst^{tm2.1(cre)Zjh} mutation (4 available); any Sst mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:297390 )

N	• mice virally expressing a cre-dependent tet transactivator exhibit normal behavior in an open field and exploration of an elevated plus maze

impaired cued conditioning behavior ( J:297390 )

• mice virally expressing a cre-dependent tet transactivator exhibit reduced long term memory in a cued threat-conditioning paradigm compared with wild-type

• however, supplementation with doxycycline rescues phenotype

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