Tg(dlx5a-cre)1Mekk
Transgene Detail

Summary

• Symbol: Tg(dlx5a-cre)1Mekk
• Name: transgene insertion 1, Marc Ekker
• MGI ID: MGI:3758328
• Synonyms: Dlx5/6-Cre, Dlx5/6i-Cre, line 8561, Tg(dlx6a-cre)1Mars, Tg(dlx6a-cre)1Mekk
• Transgene: Tg(dlx5a-cre)1Mekk Location: unknown
• Alliance: Tg(dlx5a-cre)1Mekk page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(dlx5a-cre)1Mekk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  zebrafish

  dlx5a (30569)

  Dlx5	(MGI:101926)

• Mutation details: A cre gene was placed under the control of the I56i and I56ii enhancer elements of zebrafish dlx5a and a 3.5kb genomic DNA fragment flanking the 5' region of the zebrafish dlx6a open reading frame and containing the 5'UTR. The dlx6a flanking region on its own cannot produce tissue specific expression but increases the activity of the enhancers to produce expression that recapitulate endogenous Dlx5 expression. Tissue specific expression was confirmed by test crosses to reporter mice strains, including Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(ACTB-Bgeo/GFP)21Lbe and Gt(ROSA)26Sor^tm1Sor. (J:122066)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	dlx5a (zebrafish) Summary of all recombinase alleles driven by dlx5a. Comparative matrix view of recombinase activities Alliance zebrafish dlx5a gene page

Expression

In Mice Carrying this Mutation:

77 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:122066 Monory K, et al., The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 2006 Aug 17;51(4):455-66
• All: 126 reference(s)