Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(Tor1b)Wtd mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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behavior/neurological
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N |
• mice show normal postnatal growth and survival, and normal juvenile reflexes, including negative geotaxis, surface righting, and forelimb hang
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk1tm2.1Lfr mutation
(0 available);
any
Ntrk1 mutation
(60 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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nervous system
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• impaired cholinergic innervation into the frontal cortex at P7
• decrease in cholinergic fiber density and absence of a clear laminar pattern of innervation in the hippocampus at P14
• complete absence of cholinergic fibers in the hippocampus and only a small number of fibers in the frontal cortex at P90
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behavior/neurological
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• measurable decline in amygdala-dependent, but not hippocampal-dependent, cognitive performance
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• significant decrease in recognition of a novel object
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.1Cogr mutation
(1 available);
any
Cdkl5 mutation
(19 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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behavior/neurological
 N |
• mice do not exhibit abnormal clasping or head tracking
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.1Cogr mutation
(1 available);
any
Cdkl5 mutation
(19 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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behavior/neurological
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N |
• mice do not exhibit abnormal clasping or head tracking
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Bird mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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mortality/aging
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N |
• mice survive to at least 80 weeks of age
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behavior/neurological
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N |
• mice show similar grooming times to controls
• mice have a nonsignificant trend to reduced total distance traveled
• time exhibiting aggressive behavior such as wrestling, tail-rattling, boxing, and mounting is similar to controls
• mice exhibit intact olfactory recognition and habituation in response to a novel odorant at 11 weeks of age
• at 12 weeks, mice have intact nociception demonstrated by a hot-plate or tail-flick assay
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• mice show impaired maximum acoustic startle response to 120dB
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• mice display more footslips, shorter latency to fall on wire, reduced number of side touches on dowel and shorter latency to fall from rotarod compared to controls
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• mice show a 200% increase relative to control in number of holes explored with 2 or more sequential nose pokes in a holeboard assay
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• nest building is impaired
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• mice show increased social interaction with novel and familiar partners; time spent with novel partners is 60% higher than in controls in a 3-chamber assay
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nervous system
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• 24 week-old mice show increased prepulse inhibition at 74 dB
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respiratory system
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N |
• mice show no alterations in tidal volume or minute volume, and display no apneas
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1tm1.2Ltz mutation
(1 available);
any
Cnr1 mutation
(43 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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nervous system
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• depolarization-induced suppression of inhibition, as measured by evoked inhibitory postsynaptic current amplitude, is abolished
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behavior/neurological
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N |
• 30 mg/kg kainic acid induces similar seizures as in wild-type mice and diazepam protects mice and wild-type mice similarly against kainic acid-induced seizures
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1tm1.2Ltz mutation
(1 available);
any
Cnr1 mutation
(43 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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nervous system
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• probability that pyramidal cells will receive VGAT+/VGLUT3+ boutons in layer 2/3 of the neocortex is increased
• however, interneuron migration and neurochemical specification are normal
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behavior/neurological
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• mice exhibit limb clasping in the tail suspension test at P70
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• mice exhibit abnormal twisting movements and 9 of 11 mice show trunk twisting during the tail suspension test
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nervous system
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• mice exhibit 33.5% fewer dorsal striatal cholinergic interneurons at P70
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• mice exhibit 33.5% fewer dorsal striatal cholinergic interneurons at P70, indicating degeneration
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behavior/neurological
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N |
• mice show rescue of the limb clasping phenotype and the twisting movements seen in Tor1atm1Wtd/Tor1atm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice
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nervous system
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N |
• mice show prevention of striatal cholinergic interneuron degeneration that occurs in Tor1atm1Wtd/Tor1atm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation
(0 available);
any
Crhr1 mutation
(26 available)
Tg(dlx5a-cre)1Mekk mutation
(2 available)
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behavior/neurological
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N |
• mice exhibit normal anxiety-related behavior, forced swim test, and auditory fear conditioning
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homeostasis/metabolism
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