Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation
(1 available);
any
Aplp2 mutation
(30 available)
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normal phenotype
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• normal size, fertility and behavior
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nervous system
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• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice that is not as severe as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotes
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nervous system
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• at E16.5, endplate band width and number are increased compared to in wild-type mice but not as severely as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotes
• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice that is not as severe as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotes
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nervous system
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• at E16.5, endplate band width and number are increased compared to in wild-type mice that is as severe as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotes
• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type that is as severe as in Aplp2tm1Dbo Apptm1.2Zhe double homozygotesmice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation
(1 available);
any
Aplp2 mutation
(30 available)
Apptm2.1Zhe mutation
(0 available);
any
App mutation
(89 available)
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mortality/aging
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• most homozygotes die by 21 days of age
• born in normal numbers
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nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation
(1 available);
any
Aplp2 mutation
(30 available)
Apptm1.2Zhe mutation
(0 available);
any
App mutation
(89 available)
Apptm2.1Zhe mutation
(0 available);
any
App mutation
(89 available)
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mortality/aging
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• most homozygotes die by 21 days of age
• born in normal numbers
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mortality/aging
nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation
(1 available);
any
Aplp2 mutation
(30 available)
Apptm1.2Zhe mutation
(0 available);
any
App mutation
(89 available)
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nervous system
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• at E16.5, endplate band width and number are increased compared to in wild-type mice
• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice
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mortality/aging
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• incomplete penetrance, 80% of mice die within one week of birth
• lethality is not due to cardiopulmonary function as the heart and lungs appeared normal
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reproductive system
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• no abnormalities in ovaries and testis, indicating that physiological or behavioral correlates, rather than anatomical aspects, are responsible for decrease in fertility
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behavior/neurological
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• most pups have little or no milk in stomach, however no lesions in the face, palate, esophagous, stomach, intestine, or colon were seen and cranial nerves implicated in feeding appeared normal
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• by 12-36 hours after birth, double homozygous mice appear weaker, however mice exhibit normal muscle histology, abundant lower motor neurons in the ventral horn of spinal cords, and normal neuromuscular transmission
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growth/size/body
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• survivors lag behind in growth and are 20-30% smaller, even into adulthood, compared to controls
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integument
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• become pale by 12-36 hours after birth
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nervous system
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• at E14.5, acetylcholine receptor clusters are less robust compared to in control mice
• however, prepatterned acetylcholine receptors are distributed along the central region
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation
(1 available);
any
Aplp2 mutation
(30 available)
Apptm2Cwe mutation
(0 available);
any
App mutation
(89 available)
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mortality/aging
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• no defect detected grossly or microscopically
• no animals survive to weaning age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp1tm1Umu mutation
(0 available);
any
Aplp1 mutation
(26 available)
Aplp2tm1Dbo mutation
(1 available);
any
Aplp2 mutation
(30 available)
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mortality/aging
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• no obvious defect detected grossly or microscopically
• mice were born at normal Mendelian frequency (29% of 171 animals), but no surviving double mutants were found at P1, indicating that a combined deficiency results in lethality within the first day after birth
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mortality/aging
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• although born in Mendelian ratios, few mice survive to adulthood
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nervous system
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• neuromuscular junction exhibit mislocalization of choline transporters and reduced synaptophysin staining compared with wild-type mice
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mortality/aging
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• although born in Mendelian ratios, no mice survive to weaning
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation
(1 available);
any
Aplp2 mutation
(30 available)
Apptm3.1Zhe mutation
(0 available);
any
App mutation
(89 available)
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Neuromuscular synapse defects in Apptm3.1Zhe/Apptm3.1Zhe Aplp2tm1Dbo/Aplp2tm1Dbo mice
mortality/aging
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• although born in Mendelian ratios, few mice survive to adulthood
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nervous system
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• neuromuscular junction exhibit mislocalization of choline transporters compared with wild-type mice
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Analysis Tools