Aplp1^tm1Umu
Targeted Allele Detail

Summary

• Symbol: Aplp1^tm1Umu
• Name: amyloid beta precursor like protein 1; targeted mutation 1, Ulrike Muller
• MGI ID: MGI:2154545
• Synonyms: APLP1-
• Gene: Aplp1 Location: Chr7:30134407-30144960 bp, - strand Genetic Position: Chr7, 18.32 cM
• Alliance: Aplp1^tm1Umu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65196
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced an ~8kb segment of the gene, comprising 2.5kb of the putative promoter, the first exon containing the ATG translational start codon, and genomic sequences containing ~50% of the coding region of the gene. Northern and Western blots of brain tissue from homozygous mutant mice showed no detectable transcript and protein, respectively. (J:65196)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aplp1 Mutation: 26 strains or lines available

References

• Original: J:65196 Heber S, et al., Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci. 2000 Nov 1;20(21):7951-63
• All: 11 reference(s)