All Phenotypes Aplp1<tm1Umu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aplp1^tm1Umu
targeted mutation 1, Ulrike Muller
MGI:2154545

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aplp1^tm1Umu/Aplp1^tm1Umu	involves: 129/Sv * C57BL/6	MGI:2176988
cx2	Aplp1^tm1Umu/Aplp1^tm1Umu Aplp2^tm1Dbo/Aplp2^tm1Dbo	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J	MGI:2176991
cx3	Aplp1^tm1Umu/Aplp1^tm1Umu App^tm2Cwe/App^tm2Cwe	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:2176990

Allelic Composition	Aplp1^tm1Umu/Aplp1^tm1Umu
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp1^tm1Umu mutation (0 available); any Aplp1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:65196 )

• 10% decrease in body weight at 9 weeks of age

Allelic Composition	Aplp1^tm1Umu/Aplp1^tm1Umu Aplp2^tm1Dbo/Aplp2^tm1Dbo
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp1^tm1Umu mutation (0 available); any Aplp1 mutation (23 available)
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:65196 )

• no obvious defect detected grossly or microscopically

• mice were born at normal Mendelian frequency (29% of 171 animals), but no surviving double mutants were found at P1, indicating that a combined deficiency results in lethality within the first day after birth

Allelic Composition	Aplp1^tm1Umu/Aplp1^tm1Umu App^tm2Cwe/App^tm2Cwe
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp1^tm1Umu mutation (0 available); any Aplp1 mutation (23 available)
App^tm2Cwe mutation (0 available); any App mutation (118 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:65196 )

• 10% decrease in body weight at 9 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24