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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Brca2tm1Cam
targeted mutation 1, University of Cambridge
MGI:1930616
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Brca2tm1Cam/Brca2tm1Cam 129S/SvEv-Brca2tm1Cam MGI:3831436
hm2
 		Brca2tm1Cam/Brca2tm1Cam involves: 129S/SvEv MGI:3831515
hm3
 		Brca2tm1Cam/Brca2tm1Cam involves: 129S/SvEv * MF1 MGI:3831435
cn4
 		Brca2tm1Brn/Brca2tm1Cam
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0 		involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N MGI:4940096
cn5
 		Brca2tm1Cam/Brca2tm1Brn
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0 		involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N MGI:4940102
cn6
 		Brca2tm1Cam/Brca2tm1Brn
Tg(Pdx1-cre)6Tuv/0
Trp53tm3Tyj/Trp53+ 		involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N MGI:4940104
cn7
 		Brca2tm1Cam/Brca2tm1Brn
Tg(Pdx1-cre)6Tuv/0 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N MGI:4940106
cn8
 		Brca2tm1Cam/Brca2+
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N MGI:4940099
cn9
 		Brca2tm1Cam/Brca2+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N MGI:4940100


Genotype
MGI:3831436
hm1
Allelic
Composition		 Brca2tm1Cam/Brca2tm1Cam
Genetic
Background		 129S/SvEv-Brca2tm1Cam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:46812 )
• 90% of neonates are found dead
postnatal lethality, incomplete penetrance ( J:46812 )
• 50% of mice that are born alive die by weaning
prenatal lethality, incomplete penetrance ( J:46812 )
• only 2.7% of the expected 25% are born alive
• fewer than expected mice are present at E10.5

skeleton

growth/size/body
embryonic growth retardation ( J:46812 )

embryo




Genotype
MGI:3831515
hm2
Allelic
Composition		 Brca2tm1Cam/Brca2tm1Cam
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:93261 )
• mouse embryonic fibroblasts (MEFs) exhibit an extended time spent in anapahse compared to wild-type cells
• binucleated MEFs are more frequent than in wild-type cells
• completion of cytokinesis in MEFs is impaired compared to in wild-type cells




Genotype
MGI:3831435
hm3
Allelic
Composition		 Brca2tm1Cam/Brca2tm1Cam
Genetic
Background		 involves: 129S/SvEv * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:46812 )
• all mice that survive weaning develop and die of thymic lymphomas between 12 and 14 weeks of age
neonatal lethality, incomplete penetrance ( J:46812 )
• 90% of neonates are found dead
perinatal lethality, incomplete penetrance ( J:46812 )
• only 11.2% of the expected 25% are born alive
postnatal lethality, incomplete penetrance ( J:46812 )
• 50% of mice that are born alive die by weaning
embryonic lethality during organogenesis, incomplete penetrance ( J:46812 )
• fewer than expected mice are present at E10.5

reproductive system
absent germ cells ( J:46812 )
• adult males and females lack germ cells

neoplasm
increased T cell derived lymphoma incidence ( J:46812 )
• all mice that survive weaning develop and die of thymic lymphomas between 12 and 14 weeks of age
• thymic tumors disrupt the cortical-medullary structure of the thymus with monomorphic lymphoblastic cells
• tumor infiltrate in the lungs is observed in mice with thymic lymphomas

skeleton

immune system
increased thymus weight ( J:46812 )
• thymic weight is double wild-type

growth/size/body
embryonic growth retardation ( J:46812 )

hematopoietic system
increased thymus weight ( J:46812 )
• thymic weight is double wild-type

embryo

endocrine/exocrine glands
increased thymus weight ( J:46812 )
• thymic weight is double wild-type
increased T cell derived lymphoma incidence ( J:46812 )
• all mice that survive weaning develop and die of thymic lymphomas between 12 and 14 weeks of age
• thymic tumors disrupt the cortical-medullary structure of the thymus with monomorphic lymphoblastic cells
• tumor infiltrate in the lungs is observed in mice with thymic lymphomas

cellular
absent germ cells ( J:46812 )
• adult males and females lack germ cells




Genotype
MGI:4940096
cn4
Allelic
Composition		 Brca2tm1Brn/Brca2tm1Cam
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Brn mutation (5 available); any Brca2 mutation (132 available)
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic acinar cell carcinoma incidence ( J:166678 )
• about 18% of assessable tumor cases develop an acinar-cell carcinoma component of pancreatic tumors
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• high penetrance (29 of 30 mutants) of pancreatic ductal adenocarcinomas

mortality/aging
premature death ( J:166678 )
• average survival time is 84 days, with a range of 48-110 days

endocrine/exocrine glands
increased pancreatic acinar cell carcinoma incidence ( J:166678 )
• about 18% of assessable tumor cases develop an acinar-cell carcinoma component of pancreatic tumors
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• high penetrance (29 of 30 mutants) of pancreatic ductal adenocarcinomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
 J:166678




Genotype
MGI:4940102
cn5
Allelic
Composition		 Brca2tm1Cam/Brca2tm1Brn
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Brn mutation (5 available); any Brca2 mutation (132 available)
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
exocrine pancreatic insufficiency ( J:166678 )
• pancreatic insufficiency; spectrum of anomalies are seen from isolated paucity of the islets of Langerhans to complete fibro-inflammatory or cystic degeneration of both the endocrine and exocrine pancreas

endocrine/exocrine glands
increased pancreas apoptosis ( J:166678 )
• pancreata from 6 day old mutants exhibits an increase in apoptotic cells compared to controls
exocrine pancreatic insufficiency ( J:166678 )
• pancreatic insufficiency; spectrum of anomalies are seen from isolated paucity of the islets of Langerhans to complete fibro-inflammatory or cystic degeneration of both the endocrine and exocrine pancreas
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• mutants not succumbing to pancreatic insufficiency later develop pancreatic ductal adenocarcinomas with a moderate latency and incomplete penetrance (6 of 32 mutants)

mortality/aging
premature death ( J:166678 )
• mutants exhibit shortened pancreatic ductal adenocarcinoma-free survival

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• mutants not succumbing to pancreatic insufficiency later develop pancreatic ductal adenocarcinomas with a moderate latency and incomplete penetrance (6 of 32 mutants)

cellular
increased pancreas apoptosis ( J:166678 )
• pancreata from 6 day old mutants exhibits an increase in apoptotic cells compared to controls




Genotype
MGI:4940104
cn6
Allelic
Composition		 Brca2tm1Cam/Brca2tm1Brn
Tg(Pdx1-cre)6Tuv/0
Trp53tm3Tyj/Trp53+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Brn mutation (5 available); any Brca2 mutation (132 available)
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
exocrine pancreatic insufficiency ( J:166678 )
• pancreatic insufficiency is occasionally observed in mutants

endocrine/exocrine glands
exocrine pancreatic insufficiency ( J:166678 )
• pancreatic insufficiency is occasionally observed in mutants

mortality/aging
premature death ( J:166678 )
• premature death before 600 days of age due to lymphoid malignancies and sarcomas

neoplasm
increased malignant tumor incidence ( J:166678 )
• mutants develop lymphoid malignancies




Genotype
MGI:4940106
cn7
Allelic
Composition		 Brca2tm1Cam/Brca2tm1Brn
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Brn mutation (5 available); any Brca2 mutation (132 available)
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
exocrine pancreatic insufficiency ( J:166678 )
• small fraction of mutants develop pancreatic insufficiency

endocrine/exocrine glands
exocrine pancreatic insufficiency ( J:166678 )
• small fraction of mutants develop pancreatic insufficiency

mortality/aging
premature death ( J:166678 )
• premature death in the small fraction of mutants with pancreatic insufficiency




Genotype
MGI:4940099
cn8
Allelic
Composition		 Brca2tm1Cam/Brca2+
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• 26 of 30 mutants develop pancreatic ductal adenocarcinomas

mortality/aging
premature death ( J:166678 )
• average survival time is 143 days, with a range of 91-191 days

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• 26 of 30 mutants develop pancreatic ductal adenocarcinomas




Genotype
MGI:4940100
cn9
Allelic
Composition		 Brca2tm1Cam/Brca2+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• 12 of 40 mutants develop pancreatic ductal adenocarcinomas

mortality/aging
premature death ( J:166678 )
• reduction in pancreatic ductal adenocarcinoma-free survival

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• 12 of 40 mutants develop pancreatic ductal adenocarcinomas




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory