Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
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growth/size/body
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• beginning at 5 weeks of age, male mice are almost twice as heavy as Stat3tm2Aki homozygotes controls and female mice exhibit an increased in body weight compared to Stat3tm2Aki homozygotes controls
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• at 5 weeks of age, male mice exhibit an increased in body length compared to Stat3tm2Aki homozygotes controls
• at 10 weeks of age, both male and female mice exhibit an increased in body length compared to Stat3tm2Aki homozygotes controls
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homeostasis/metabolism
behavior/neurological
reproductive system
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N |
• mice exhibit normal reproduction
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
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immune system
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• following Cre recombination and Friend virus (FV) infection, the ability to form Epo-independent colonies is reduced in an in vivo
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mortality/aging
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N |
• under normoxic conditions, mice treated with doxycycline from E0 to P25 exhibit no differences in survival at E18.5 or after birth relative to control littermates
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homeostasis/metabolism
respiratory system
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N |
• under normoxic conditions, mice treated with doxycycline from E0 to P25 exhibit normal lung size and morphology and normal pulmonary mechanics relative to control littermates
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• after exposure to hyperoxia, doxycycline-treated mice display loss of alveolar capillary membrane integrity, perivascular edema, and severe vascular cell necrosis relative to control littermates
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• after exposure to hyperoxia, doxycycline-treated mice display widespread alveolar epithelial cell necrosis without apoptosis
• after exposure to hyperoxia, doxycycline-treated mice display extensive epithelial cell necrosis in the bronchiolar epithelium
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• after exposure to hyperoxia, doxycycline-treated mice display increased infiltration by polymorphonuclear cells and alveolar macrophages along with an increased production of IL-1beta, IL-6, and MIP-2 relative to control littermates
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• after exposure to hyperoxia, doxycycline-treated mice display widespread alveolar epithelial cell necrosis without apoptosis, hyaline membrane formation, loss of alveolar capillary membrane integrity, and increased inflammation consistent with severe epithelial cell injury
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• after exposure to hyperoxia, staining for proSP-C, a selective marker for type II cells, is decreased in doxycycline-treated mice
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• after exposure to hyperoxia, doxycycline-treated mice display hyaline membrane formation
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• after exposure to hyperoxia, doxycycline-treated mice display significantly increased lung elastance
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• after exposure to hyperoxia, doxycycline-treated mice display significantly increased tissue damping
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• doxycycline-treated mice develop acute respiratory distress within 72 hrs of hyperoxia, unlike control littermates which develop severe respiratory symptoms after 5 or more days of continued exposure
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• after exposure to hyperoxia, doxycycline-treated mice display altered pulmonary mechanics, indicating a decline in pulmonary function
• however, hysteresivity and newtonian resistance remain unaffected
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• after exposure to hyperoxia, doxycycline-treated mice display a significant increase in airway resistance relative to control littermates
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• after exposure to hyperoxia, doxycycline-treated mice display reduced lung compliance relative to control littermates
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• doxycycline-treated mice exhibit respiratory failure after relatively short periods of hyperoxia
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• after exposure to hyperoxia, doxycycline-treated mice show significantly increased BALF protein content and reduced alveolar surfactant phospholipid (saturated phosphatidylcholine) pool sizes relative to control littermates
• after exposure to hyperoxia, SP-B is undetectable while SP-A is significantly decreased in alveolar lavage of doxycycline-treated mice
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immune system
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• after exposure to hyperoxia, doxycycline-treated mice display increased IL-1beta, IL-6, and MIP-2 levels in lung tissue relative to control littermates
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• after exposure to hyperoxia, doxycycline-treated mice display increased infiltration by polymorphonuclear cells and alveolar macrophages along with an increased production of IL-1beta, IL-6, and MIP-2 relative to control littermates
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cardiovascular system
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• after exposure to hyperoxia, doxycycline-treated mice display loss of alveolar capillary membrane integrity, perivascular edema, and severe vascular cell necrosis relative to control littermates
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cellular
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• after exposure to hyperoxia, doxycycline-treated mice display widespread alveolar epithelial cell necrosis without apoptosis
• after exposure to hyperoxia, doxycycline-treated mice display extensive epithelial cell necrosis in the bronchiolar epithelium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(Lck-cre)1Jtak mutation
(3 available)
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immune system
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• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
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• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal
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hematopoietic system
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• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
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• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal
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cellular
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• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
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• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Aki mutation
(6 available);
any
Stat3 mutation
(70 available)
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(NEFL-cre)50Msd mutation
(0 available)
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nervous system
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• motor neurons require higher concentrations of CNTF than wild-type cells to survive in culture
• however, the number of facial and spinal neurons in mice is normal
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• motor neurons require higher concentrations of CNTF than wild-type cells to survive in culture
• however, the number of facial and spinal neurons in mice is normal
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homeostasis/metabolism
digestive/alimentary system
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N |
• mice exhibit normal Th1 responses and do not develop colitis, unlike Stat3 null mice
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normal phenotype
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• mice are viable and developmentally normal with no detectable craniofacial abnormalities
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm10.1Sor mutation
(0 available);
any
Fgfr1 mutation
(221 available)
Fgfr1tm5.1Sor mutation
(0 available);
any
Fgfr1 mutation
(221 available)
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
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craniofacial
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N |
• none of the 4 mice examined exhibit cleft palate, likely due to the low penetrance of cleft palate found in Fgfr1tm5.1Sor/Fgfr1tm10.1Sor mice (2 of 13)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(KRT5-cre)1Tak mutation
(0 available)
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vision/eye
immune system
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• lymphocyte infiltrating periocular dermatitis
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integument
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• keratinocyte migration is impaired
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• lymphocyte infiltrating periocular dermatitis
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• mice exhibit small clustering of matrix cells, which resemble undifferentiated hair germs, distorted or curved hair shafts or gigantic hair bulbs with bizarre shapes
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• unlike in wild-type mice the second anagen does not occur
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• mice exhibit skin ulcerations that worsen with age
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• during the late anagen stage mice exhibit dermal fibrosis with inflammatory infiltrate and atrophic change in adipose tissue
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endocrine/exocrine glands
cellular
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• keratinocyte migration is impaired
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homeostasis/metabolism
immune system
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• splenic interferon-gamma producing CD4+ T cells are increased in mice treated with PMA and ionomycin
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• CD4+ cells produce increased levels of interferon-gamma
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• IL-12 production is enhanced compared to in wild-type mice
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digestive/alimentary system
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• as early as 5 to 6 weeks, mice exhibit thickened colon walls with reduced glands compared to wild-type mice and by 24 weeks all regions of the colon are affected
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hematopoietic system
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• splenic interferon-gamma producing CD4+ T cells are increased in mice treated with PMA and ionomycin
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immune system
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• few mice exhibit inflammation characteristic of colitis and symptoms were less severe than in Stat3 null mice
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• interferon-gamma production is less than in Stat 3 null mice
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• unlike in wild-type mice, LPS fails to induce cytokine production
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digestive/alimentary system
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• few mice exhibit inflammation characteristic of colitis and symptoms were less severe than in Stat3 null mice
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immune system
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• mice develop enterocolitis that is as severe as in Stat3 null mice
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• CD4+ cells produce increased levels of interferon-gamma
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• macrophages produce increased amounts of IL-12p40 that are comparable to in Stat3 null mice
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• macrophages produce increased amounts of IL-6 that are comparable to in Stat3 null mice
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digestive/alimentary system
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• mice develop enterocolitis that is as severe as in Stat3 null mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(KRT5-cre/ERT2)AJdg mutation
(1 available)
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cellular
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• DMBA causes increased apoptosis in the epidermis of skin where conditional disruption of Stat3 has been induced by Tamoxifen
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neoplasm
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• tumor development after treatment with both DMBA and TPA was significantly reduced in mice deficient in Stat3 expression as a result of tamoxifen treatment
• tamoxifen induced disruption of Stat3 inhibits growth of pre existing papillomas
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integument
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• reduced TPA induced epidermal proliferation after Stat3 disrutption mediated by tamoxifen
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(Alb1-cre)1Dlr mutation
(3 available)
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skeleton
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• bone volume to tissue volume is reduced by half compared to controls
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• trabecular number and trabecular thickness are decreased in the tibia by about a third
• trabecular separation is increased by more than a third
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• mineral apposition rate and bone formation rate are significantly reduced in these mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1Maka mutation
(0 available);
any
Pdpk1 mutation
(138 available)
Stat3tm2Aki mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(Alb1-cre)1Dlr mutation
(3 available)
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immune system
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• mice develop chronic enterocolitis although it is not as severe as in Stat3 null mice
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• splenic interferon-gamma producing CD4+ T cells are increased in mice treated with PMA and ionomycin but not a much as in Stat3 null mice
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• intestinal lamina propria CD4+ T cells produce more interferon-gamma than wild-type cells
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• macrophages produce more IL-6 than wild-type cells but less than Stat3 null cells
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• macrophages produce more TNF-alpha than wild-type cells but less than Stat3 null cells
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digestive/alimentary system
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• as early as 5 to 6 weeks, mice exhibit thickened colon walls with reduced glands compared to wild-type mice but unlike in Stat3 null mice not all regions of the colon are affected
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• mice develop chronic enterocolitis although it is not as severe as in Stat3 null mice
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hematopoietic system
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• splenic interferon-gamma producing CD4+ T cells are increased in mice treated with PMA and ionomycin but not a much as in Stat3 null mice
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Analysis Tools