All Phenotypes Alx4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Alx4⁺
wild type
MGI:1857474

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Alx4^M1Yzcm/Alx4⁺	C57BL/6-Alx4^M1Yzcm	MGI:5502882
ht2	Alx4^Lst-2J/Alx4⁺	C57BL/6J-Alx4^Lst-2J/J	MGI:5695544
ht3	Alx4^tm1Rwi/Alx4⁺	involves: 129S6/SvEvTac	MGI:3050639
ht4	Alx4^tm1Rwi/Alx4⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:3050643
ht5	Alx4^lst-Alb/Alx4⁺	involves: C3H/HeJ * C57BL/6	MGI:5140813
cx6	Alx4^tm1Rwi/Alx4⁺ Bmp4^tm1Blh/Bmp4⁺	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	MGI:2166749
cx7	Alx1^tm1Crm/Alx1^tm1Crm Alx4^tm1Rwi/Alx4⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3050585
cx8	Alx1^tm1Crm/Alx1⁺ Alx4^tm1Rwi/Alx4⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3050576
cx9	Alx4^lst/Alx4⁺ Fmn1^ld-TgHD/Fmn1⁺	involves: BALB/c * C57BL/6 * CD-1 * FVB/N	MGI:4355955
cx10	Alx1^em1Jian/Alx1^em1Jian Alx4^Lst-2J/Alx4⁺	involves: C57BL/6J * C57BL/6N * CD-1	MGI:7336700
cx11	Alx4^lst/Alx4⁺ Grem1^ld-J/Grem1⁺	involves: CBA/Ca * NHO	MGI:4355958
cx12	Alx4^lst/Alx4⁺ Grem1^ld/Grem1⁺	Not Specified	MGI:4355956

Allelic Composition	Alx4^M1Yzcm/Alx4⁺
Genetic Background	C57BL/6-Alx4^M1Yzcm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^M1Yzcm mutation (0 available); any Alx4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

preaxial polydactyly ( J:199512 )

• in one hindlimb, rarely in both

Allelic Composition	Alx4^Lst-2J/Alx4⁺
Genetic Background	C57BL/6J-Alx4^Lst-2J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^Lst-2J mutation (1 available); any Alx4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

preaxial polydactyly ( J:223288 )

• preaxial polydactyly on one hind limb is often found

craniofacial

short snout ( J:223288 )

growth/size/body

short snout ( J:223288 )

Allelic Composition	Alx4^tm1Rwi/Alx4⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^tm1Rwi mutation (0 available); any Alx4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:43769 )

• heterozygotes are apparently normal and do NOT display polydactyly

Allelic Composition	Alx4^tm1Rwi/Alx4⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^tm1Rwi mutation (0 available); any Alx4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:49152 )

• notably, heterozygous F1 progeny of a 129/Sv x C57BL/6J mating display hindlimb polydactyly

Allelic Composition	Alx4^lst-Alb/Alx4⁺
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^lst-Alb mutation (0 available); any Alx4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:49152 )

• Background Sensitivity: penetrance is sensitive to genetic background

preaxial polydactyly ( J:49152 )

• Background Sensitivity: found on the hindlimbs of this genotypic background but not on a 129/Sv background

• C57BL/6 is a permissive background

Allelic Composition	Alx4^tm1Rwi/Alx4⁺ Bmp4^tm1Blh/Bmp4⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^tm1Rwi mutation (0 available); any Alx4 mutation (21 available)
Bmp4^tm1Blh mutation (2 available); any Bmp4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:42445 )

• all double heterozygotes exhibit ectopic anterior digits only on the hindlimbs

• extra digit extends from a duplicated metatarsal

• extra digits are triphalangeal

• post axial "nubbins" also seen on the forelimbs of 80% of heterozygotes

Allelic Composition	Alx1^tm1Crm/Alx1^tm1Crm Alx4^tm1Rwi/Alx4⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx1^tm1Crm mutation (0 available); any Alx1 mutation (22 available)
Alx4^tm1Rwi mutation (0 available); any Alx4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal basisphenoid bone morphology ( J:51128 )

short mandible ( J:51128 )

• mandibular reduction is mainly restricted to the region anterior to the alveolar process that surrounds the molars

abnormal nasal septum cartilage morphology ( J:51128 )

• mutants that carry three mutant alleles in any combination show cleft face associated with failure to fuse the cartilages of the nasal septum

midline facial cleft ( J:51128 )

• mutant mice show a midline fusion defect that results in cleft face

respiratory system

abnormal nasal septum cartilage morphology ( J:51128 )

• mutants that carry three mutant alleles in any combination show cleft face associated with failure to fuse the cartilages of the nasal septum

skeleton

abnormal basisphenoid bone morphology ( J:51128 )

short mandible ( J:51128 )

• mandibular reduction is mainly restricted to the region anterior to the alveolar process that surrounds the molars

abnormal nasal septum cartilage morphology ( J:51128 )

• mutants that carry three mutant alleles in any combination show cleft face associated with failure to fuse the cartilages of the nasal septum

nervous system

exencephaly ( J:51128 )

• all double homozygous null mice display exencephaly

growth/size/body

short mandible ( J:51128 )

• mandibular reduction is mainly restricted to the region anterior to the alveolar process that surrounds the molars

abnormal nasal septum cartilage morphology ( J:51128 )

• mutants that carry three mutant alleles in any combination show cleft face associated with failure to fuse the cartilages of the nasal septum

midline facial cleft ( J:51128 )

• mutant mice show a midline fusion defect that results in cleft face

Allelic Composition	Alx1^tm1Crm/Alx1⁺ Alx4^tm1Rwi/Alx4⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:51128 )

• double heterozygotes appear phenotypically normal

Allelic Composition	Alx4^lst/Alx4⁺ Fmn1^ld-TgHD/Fmn1⁺
Genetic Background	involves: BALB/c * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^lst mutation (0 available); any Alx4 mutation (21 available)
Fmn1^ld-TgHD mutation (0 available); any Fmn1 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:17401 )

N	• have normal limbs

Allelic Composition	Alx1^em1Jian/Alx1^em1Jian Alx4^Lst-2J/Alx4⁺
Genetic Background	involves: C57BL/6J * C57BL/6N * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx1^em1Jian mutation (0 available); any Alx1 mutation (22 available)
Alx4^Lst-2J mutation (1 available); any Alx4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal presphenoid bone morphology ( J:320497 )

• at E18.5, the presphenoid bone in the cranial base is severely malformed

abnormal premaxilla morphology ( J:320497 )

• at E18.5, the premaxilla is severely malformed

abnormal lateral nasal prominence morphology ( J:320497 )

• at E10.5, a clear reduction of Pax7 expression is observed in the caudal region of the lateral nasal process (LNP); both Lhx6 and Lhx8 mRNAs show higher ectopic expression in the caudal region of the LNP than in Alx1^em1Jian homozygotes

midline cleft upper lip ( J:320497 )

• at E18.5, severe notching of the upper lip is observed

short philtrum ( J:320497 )

• at E18.5, the philtrum is further shortened relative to Alx1^em1Jian homozygotes

broad nasal bridge ( J:320497 )

• at E18.5, the nasal bridge is severely widened

depressed nasal bridge ( J:320497 )

• at E18.5, the nasal bridge is severely depressed

growth/size/body

abnormal premaxilla morphology ( J:320497 )

• at E18.5, the premaxilla is severely malformed

midline cleft upper lip ( J:320497 )

• at E18.5, severe notching of the upper lip is observed

short philtrum ( J:320497 )

• at E18.5, the philtrum is further shortened relative to Alx1^em1Jian homozygotes

broad nasal bridge ( J:320497 )

• at E18.5, the nasal bridge is severely widened

depressed nasal bridge ( J:320497 )

• at E18.5, the nasal bridge is severely depressed

skeleton

abnormal presphenoid bone morphology ( J:320497 )

• at E18.5, the presphenoid bone in the cranial base is severely malformed

abnormal premaxilla morphology ( J:320497 )

• at E18.5, the premaxilla is severely malformed

respiratory system

broad nasal bridge ( J:320497 )

• at E18.5, the nasal bridge is severely widened

depressed nasal bridge ( J:320497 )

• at E18.5, the nasal bridge is severely depressed

Allelic Composition	Alx4^lst/Alx4⁺ Grem1^ld-J/Grem1⁺
Genetic Background	involves: CBA/Ca * NHO

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^lst mutation (0 available); any Alx4 mutation (21 available)
Grem1^ld-J mutation (1 available); any Grem1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:35172 )

N	• have normal limbs

Allelic Composition	Alx4^lst/Alx4⁺ Grem1^ld/Grem1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^lst mutation (0 available); any Alx4 mutation (21 available)
Grem1^ld mutation (0 available); any Grem1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:35172 )

N	• have normal limbs

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