Analysis Tools
respiratory system
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• ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 92% reduction in number of total thymocytes
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• 94% reduction in number of double positive cells
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• most T cells in the thymus do no progress to the double negative stage
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• very few T cells are found in the thymus or periphery
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• very few CD8 T cells are found in the thymus or periphery
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• 92% reduction in number of total thymocytes
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• 94% reduction in number of double positive cells
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• most T cells in the thymus do no progress to the double negative stage
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• very few T cells are found in the thymus or periphery
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• very few CD8 T cells are found in the thymus or periphery
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• 92% reduction in number of total thymocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• occasionally
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• most tumors resemble diffuse large B cell lymphomas (in 6 of 9 mice)
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• in 3 of 9 mice
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• occasionally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• occasionally
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• most tumors resemble diffuse large B cell lymphomas (in 6 of 9 mice)
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• in 3 of 9 mice
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• occasionally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls
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• spleen has 1.9- to 2.9- fold fewer spleen cells than controls
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• anti-dsDNA antibodies of the IgG2a isotype are detected in the sera of mice from 1 to 3 months of age
• anti-dsDNA antibodies with IgM, IgG2b, IgG3 isotypes are also present with levels of IgG3 extremly high compared to controls
• at 3 months of age, levels are higher than those found in 56R mice that have peripheral T cells
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• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls
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• spleen has 1.9- to 2.9- fold fewer spleen cells than controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:142389 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice
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• mutants exhibit a reduction in plasma cells (B220low IgD-CD138+)
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• in the spleen
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• 16-18 week old mutants exhibit increased numbers of immature B cells
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• mutants exhibit an elevation in T2 and to a lesser extent T3 B cells
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• mutants exhibit an elevation in T2 and to a lesser extent T3 B cells
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• mutants exhibit an elevation in mature B cells, including both marginal zone and follicular mature B-cell subsets
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• in the spleen
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• IgE is not detectable in serum of OVA-treated mutants, but high levels are produced in treated wild-type
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• in OVA-treated mutants, serum IgG is reduced below saline-treated control levels
(J:125656)
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• IgG1 is not detected in serum after OVA challenge
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
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• decrease in anti-chromatin IgG, anti-histone IgG, and anti-dsDNA IgG
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• ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation
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• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice
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• mutants exhibit a reduction in plasma cells (B220low IgD-CD138+)
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• in the spleen
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• 16-18 week old mutants exhibit increased numbers of immature B cells
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• mutants exhibit an elevation in T2 and to a lesser extent T3 B cells
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• mutants exhibit an elevation in T2 and to a lesser extent T3 B cells
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• mutants exhibit an elevation in mature B cells, including both marginal zone and follicular mature B-cell subsets
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• in the spleen
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• IgE is not detectable in serum of OVA-treated mutants, but high levels are produced in treated wild-type
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• in OVA-treated mutants, serum IgG is reduced below saline-treated control levels
(J:125656)
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• IgG1 is not detected in serum after OVA challenge
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli, however IgG deposition in the glomeruli is not seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• triple mutants exhibit reduced lupus-like phenotypes compared to Traf3ip2 single homozygotes, with normal spleen weight and cellularity, normal B cell numbers (B cell numbers however are decreased compared to Tcrb and Tcrd double homozygous mutants), normal cervical lymph node weight and cellularity, significantly less total IgG antibodies and anti-nuclear antigen specific IgG autoantibodies, and no IgG deposition in the kidney glomeruli
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• 16-18 week old mutants exhibit a trend toward an increase in numbers of immature B cells
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• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice
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• mutants exhibit increased levels of marginal zone B cells compared to wild-type mice, however levels are similar to that seen in Traf3ip2 single homozygotes or to Tcrb and Tcrd double homozygous mutants, indicating no further increase in levels
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• decrease in the number of T cells in the spleen compared to wild-type mice and Traf3ip2 single homozygotes
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• mutants develop significantly less total IgG antibodies (IgG, IgG1, IgG2c) and anti-nuclear antigen specific IgG autoantibodies than Traf3ip2 single homozygotes
• the IgG deposition within the kidney glomeruli that is seen in Traf3ip2 single homozygotes is not seen in triple mutants
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
• serum levels of anti-chromatin IgM, anti-histone IgM, and anti-dsDNA Igm are elevated in triple mutants compared to Traf3ip2 single homozygotes
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• serum levels of anti-chromatin IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes
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• serum levels anti-dsDNA IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes
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• serum levels of anti-histone IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes
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• 16-18 week old mutants exhibit a trend toward an increase in numbers of immature B cells
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• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice
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• mutants exhibit increased levels of marginal zone B cells compared to wild-type mice, however levels are similar to that seen in Traf3ip2 single homozygotes or to Tcrb and Tcrd double homozygous mutants, indicating no further increase in levels
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• decrease in the number of T cells in the spleen compared to wild-type mice and Traf3ip2 single homozygotes
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• mutants develop significantly less total IgG antibodies (IgG, IgG1, IgG2c) and anti-nuclear antigen specific IgG autoantibodies than Traf3ip2 single homozygotes
• the IgG deposition within the kidney glomeruli that is seen in Traf3ip2 single homozygotes is not seen in triple mutants
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
• serum levels of anti-chromatin IgM, anti-histone IgM, and anti-dsDNA Igm are elevated in triple mutants compared to Traf3ip2 single homozygotes
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• kidneys show occasional obstruction of the capillary lumina
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• kidneys show occasional obstruction of the capillary lumina
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• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
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• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• accelerated disease progression
• shorter lifespans than Tg(SOD1*G93A)1Gur and Tg(SOD1*G93A)1Gur, Tcrbtm1Mom heterozygous mice
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• accelerated weight loss after disease onset compared to Tg(SOD1*G93A)1Gur, Tcrbtm1Mom heterozygous littermates, mainly after day 135
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• decreased microglia reactivity
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• accelerated disease progression
• motor neuron loss in spinal cords earlier at day 140
• accelerated motor decline after disease onset compared to Tg(SOD1*G93A)1Gur, Tcrbtm1Mom heterozygous littermates, mainly after day 135
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• decreased microglia reactivity
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• decreased microglia reactivity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about a 95% reduction in number of total thymocytes
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• double positive cells are not present
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• most T cells in the thymus do no progress to the double negative stage
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• about a 95% reduction in number of total thymocytes
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• double positive cells are not present
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• most T cells in the thymus do no progress to the double negative stage
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• about a 95% reduction in number of total thymocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about a 95% reduction in number of total thymocytes
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• double positive cells are not present
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• most T cells in the thymus do no progress to the double negative stage
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• cells are absent in the thymus
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• cells are absent in the thymus
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• about a 95% reduction in number of total thymocytes
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• double positive cells are not present
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• most T cells in the thymus do no progress to the double negative stage
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• cells are absent in the thymus
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• cells are absent in the thymus
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• about a 95% reduction in number of total thymocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• the numbers of intraepithelial lymphocytes in the small intestine is normal
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• the numbers of Thy1+ and CD8alpha,beta+ TCR-alpha,beta intraepithelial lymphocytes is increased compared to in Tcrdtm1Mom homozygotes
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• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
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• in the serum compared to wild-type mice
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• the numbers of Thy1+ and CD8alpha,beta+ TCR-alpha,beta intraepithelial lymphocytes is increased compared to in Tcrdtm1Mom homozygotes
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• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
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• in the serum compared to wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in Pigrtm1Ohw homozygotes, the numbers of intraepithelial lymphocytes in the small intestine is normal
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• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type micethe pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
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• serum IgA levels are increased compared to in wild-type mice but not as much as in Pigrtm1Ohw homozygotes
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• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type micethe pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
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• serum IgA levels are increased compared to in wild-type mice but not as much as in Pigrtm1Ohw homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants treated with dox for 3 weeks exhibit dermal infiltration mostly of mast cells and eosinophils
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• mutants treated with doxycycline (dox) for 3 weeks exhibit dermal infiltration mostly of mast cells and eosinophils
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• mutants treated with dox for 3 weeks exhibit epidermal thickening
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• dox treated mice exhibit little or no serum IgE
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• mutants treated with dox for 3 weeks exhibit dermal infiltration mostly of mast cells and eosinophils
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• dox treated mice exhibit little or no serum IgE
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after 4 weeks, mice show absence of vascular remodeling of the airways in response to Mycoplasma pulmonis infection wherease wild-type show complex growth and reorganization ot the vascular beds
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• abnormalities in epithelial cell differentiation and mucus secretion are intermediate between wild-type and Igh-6 deficient mice after M. pulmonis infection
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| N |
• proliferation of intestinal epithelial cells (IECs) and MHC class II expression on IECs is comparable to controls
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• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected
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• bacteria are present in liver and kidney of mice after 4 weeks of M. pulmonis infection, but bacteria are absent from wild-type mouse tissue
• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection
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• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Tcratm1Mom homozygotes, mice do not develop colitis
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| N |
• unlike Tcratm1Mom homozygotes, mice do not develop colitis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice have same numbers of B cells in spleen and lymph nodes as control littermates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice have same numbers of B cells in spleen and lymph nodes as control littermates
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• transgenic B cells increase in size and show upregulated MHC class II when mice are injected with T cells
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• mice show a substantial decrease in B220+ cells in bone marrow when mice receive nontransgenic T cells
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• when syngeneic wild-type T cells are transferred into Tcrb-deficient transgenic hosts, after 3 weeks the number of B cells in peripheral lymphoid tissues is decreased by ~50% compared with Tcrb-deficient mice not injected with T cells
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• transgenic B cells increase in size and show upregulated MHC class II when mice are injected with T cells
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• mice show a substantial decrease in B220+ cells in bone marrow when mice receive nontransgenic T cells
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• when syngeneic wild-type T cells are transferred into Tcrb-deficient transgenic hosts, after 3 weeks the number of B cells in peripheral lymphoid tissues is decreased by ~50% compared with Tcrb-deficient mice not injected with T cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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