Analysis Tools
homeostasis/metabolism
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• plasma total cholesterol is 25% of wild-type
• plasma cholesteryl ester synthesis is reduced
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Allele Symbol Allele Name Allele ID |
Apoa1tm1Unc targeted mutation 1, University of North Carolina MGI:1857127 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• plasma total cholesterol is 25% of wild-type
• plasma cholesteryl ester synthesis is reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reendothelialization is delayed compared to in wild-type mice following injury to the carotid artery
• mice exhibit a 52% larger area of non-reendothelialized carotid artery following injury compared to in wild-type mice
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• serum total cholesterol levels are reduced by one third compared to in wild-type mice
• esterified cholesterol is reduced 7-fold and free cholesterol 1.6-fold compared to in wild-type mice
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• Apoa1-poor HDL and Apoa1-rich HDL
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• serum total cholesterol, free cholesterol and esterified cholesterol levels in mice treated with silver nitrate to induce an acute phase response are increased more than in similarly treated wild-type mice
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• serum phospholipids levels are reduced by one third compared to in wild-type mice
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• triglyceride levels in mice treated with silver nitrate to induce an acute phase response are increased moderately compared to in similarly treated wild-type mice
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• reendothelialization is delayed compared to in wild-type mice following injury to the carotid artery
• mice exhibit a 52% larger area of non-reendothelialized carotid artery following injury compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• HDL cholesteryl ether clearance is over 20-fold higher than in wild-type mice and varies depending on the organ examined
• however, the clearance rate could be rescued by increasing plasma HDL cholesteryl ester levels
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• HDL cholesteryl ether clearance is over 20-fold higher than in wild-type mice and varies depending on the organ examined
• however, the clearance rate could be rescued by increasing plasma HDL cholesteryl ester levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 8 weeks of age, total cholesterol levels are decreased to 33% of wild-type
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• at 8 weeks of age, HDL levels are decreased to 17% of wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• plasma total cholesterol is 67% of wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 8 weeks of age, total cholesterol levels are decreased to 54% of wild-type
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• at 8 weeks of age, HDL levels are decreased to 40% of wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when fed regular chow or a high fat diet for 16 weeks, serum triglyceride levels are increased compared to similarly treated Ldlrtm1Her homozygotes
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• when fed a high fat diet, female mice exhibit a decrease in aortic cholesterol compared to similarly treated Ldlrtm1Her homozygotes
• however, aortic cholesterol levels in male mice fed a high fat diet are equivalent to in similarly treated Ldlrtm1Her homozygotes and female mice die before completion of the study
• when fed a high fat diet, mice exhibit a decrease in cholesterol content, specifically esterified cholesterol, in the adrenal gland compared to similarly treated Ldlrtm1Her homozygotes
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• when mice are fed a high fat diet or regular chow, plasma cholesterol levels are decreased relative to similarly treated Ldlrtm1Her homozygotes
• unlike male Ldlrtm1Her homozygotes, plasma cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet
• when fed a high fat diet, free cholesterol levels fail to increase as much as in similarly treated Ldlrtm1Her homozygotes
• unlike Ldlrtm1Her homozygotes, free cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet
• when mice are fed a high fat diet or regular chow, esterified cholesterol levels are decreased relative to similarly treated Ldlrtm1Her homozygotes
• unlike male Ldlrtm1Her homozygotes, esterified cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet
• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold)
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• when fed regular chow or a high fat diet for 16 weeks, serum HDL levels are decreased compared to similarly treated Ldlrtm1Her homozygotes
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• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold)
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• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold)
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• when fed a high fat diet, mice exhibit a reduced increase of 2.5-fold in liver cholesterol content compared to 11-fold in similarly treated Ldlrtm1Her homozygotes
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• female mice develop skin lesions when fed a high fat diet
• total skin cholesterol content is increased 12- to 13-fold and 5.5-fold for free cholesterol compared to in Ldlrtm1Her homozygotes
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• when fed a high fat diet, mice exhibit smaller diameter lipid droplets than in Ldlrtm1Her homozygotes
• when fed a high fat diet, mice exhibit an accumulation of inflammatory cells such as neutrophils and leukocytes around the hepatic vein unlike in Ldlrtm1Her homozygotes
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• when fed a high fat diet, mice exhibit a reduced increase of 2.5-fold in liver cholesterol content compared to 11-fold in similarly treated Ldlrtm1Her homozygotes
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• when fed a high fat diet, mice exhibit an decrease in cholesterol content, specifically esterified cholesterol, in the adrenal gland compared to in similarly treated Ldlrtm1Her homozygotes
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• when fed a high fat diet, mice exhibit a severe depletion of cytoplasmic lipid droplets unlike in Ldlrtm1Her homozygotes
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• when fed a high fat diet, mice develop a thickened dermal layer with macrophage infiltrate and cholesterol deposits
• dermal thickening associated with a high fat diet is more severe in female mice than male mice
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• when fed a high fat diet, female mice develop skin lesions beginning at 9 weeks with scratching and lesion areas that progress until animals cease eating and drinking
• skin lesions observed in mice fed a high fat diet are different than the non-fatal skin thickening observed in similarly treated Ldlrtm1Her homozygotes
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• when fed a high fat diet, female mice exhibit severe ulcerations on thickened skin of the abdomen, neck and front limbs
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• when fed a high fat diet, female mice develop pruritus (itching) and must be euthanized before the end of the 16 week study period
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub
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• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub
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• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub
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• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub
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• compared to in Apoa1tm1Unc homozygotes with or without Tg(APOA2)3Rub
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while serum cholesterol is decreased there is an increase in the ratio of unesterified to esterified cholesterol compared to in Apoa1tm1Unc homozygotes
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• triglyceride levels are increased compared to in Apoa1tm1Unc homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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