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Targeted Allele Detail
Symbol: Apoa1tm1Unc
Name: apolipoprotein A-I; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857127
Synonyms: A1-, Apo A1-, Apo A-1 KO, apoa1tm1unc, ApoA-I-
Gene: Apoa1  Location: Chr9:46139928-46141767 bp, + strand  Genetic Position: Chr9, 25.36 cM, cytoband A2-A4
Alliance: Apoa1tm1Unc page
Germline Transmission:  Earliest citation of germline transmission: J:2109
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 2 was replaced by a neomycin resistance cassette. The protein was not detectable in plasma by Ouchterlony double-immunodiffusion tests in homozygous mice. (J:2109)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Apoa1tm1Unc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Apoa1 Mutation:  16 strains or lines available
Original:  J:2109 Williamson R, et al., Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7134-8
All:  87 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory