Tg(APOA2)3Rub
Transgene Detail
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Symbol: |
Tg(APOA2)3Rub |
Name: |
transgene insertion 3, Edward M Rubin |
MGI ID: |
MGI:3052677 |
Synonyms: |
AII/Fu-9, apoA-II/A-IKO, hA-II, Hu apo AII |
Transgene: |
Tg(APOA2)3Rub Location: unknown
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Alliance: |
Tg(APOA2)3Rub page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(APOA2)3Rub expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APOA2 (336) |
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Mutation details: 5 kb of promoter sequence to the human APOA-I gene were fused to human APOA-II coding sequence. 10 copies of the transgene intergrated into the genome of this founder strain. In these mice, human APOA2 mRNA is found only in the liver. Transgenic mice express a dimeric form of human apolipoprotein A-II. Levels of murine HDL, APOA1, and APOA2 in transgenic mice were comparable to those found in normal wildtype siblings.
(J:92450)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:92450 Schultz JR, et al., Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice. J Biol Chem. 1992 Oct 25;267(30):21630-6 |
All: |
6 reference(s) |
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