All Phenotypes A<y> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

A^y
agouti yellow
MGI:1856798

Summary

41 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	A^y/A^y	101-A^y	MGI:5140011
ht2	A^y/A^w	129S1.C3-A^y/A^w Chr 19^MOLF/Ei	MGI:3838978
ht3	A^y/a	B6.Cg-A^y/J	MGI:3799322
ht4	A^y/A	involves: C3H/HeJ * C57BL/6J-A^y/a	MGI:5086113
ht5	A^y/A	involves: C57BL/6	MGI:3773447
ht6	A^y/a	involves: KK	MGI:3760281
cx7	A^y/a Sik2^tm1Htake/Sik2⁺	C57BL/6-Sik2^tm1Htake	MGI:5609871
cx8	A^y/a Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl	MGI:5297860
cx9	A^y/a Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Mae/Ccr2^tm1Mae	involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl	MGI:5297861
cx10	A^y/a Npbwr1^tm1Rck/Npbwr1^tm1Rck	involves: 129P/Ola * C57BL/6J	MGI:3526898
cx11	A^y/a Agrp^{tm2(HBEGF)Rpa}/Agrp⁺	involves: 129S4/SvJaeSor * KK/Upj	MGI:3776093
cx12	A^y/A Pepd^dal/Pepd^dal	involves: C3H/HeJ * CBA/J	MGI:5605663
cx13	A^y/A Prkar2b^tm2Gsm/Prkar2b^tm2Gsm	involves: C57BL/6	MGI:3773448
cx14	A^y/A Prkar2b^tm2Gsm/Prkar2b⁺	involves: C57BL/6	MGI:3773449
cx15	A^y/a Mssq6^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833460
cx16	A^y/a Mssq5^C57BL/6JJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833454
cx17	A^y/a Mssq6^C57BL/6JJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833456
cx18	A^y/a Mssq7^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833471
cx19	A^y/a Mssq9^C57BL/6JJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833969
cx20	A^y/a Mssq10^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833971
cx21	A^y/a Mssq11^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833973
cx22	A^y/a Mssq12^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833975
cx23	A^y/a Mssq13^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833977
cx24	A^y/a Mssq13^C57BL/6JJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833979
cx25	A^y/a Mssq14^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833981
cx26	A^y/a Mssq16^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833984
cx27	A^y/a Mssq1^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833436
cx28	A^y/a Mssq2^C57BL/6JJcl/Mssq2^KK/TaJcl	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833439
cx29	A^y/a Mssq3^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833448
cx30	A^y/a Mssq4^KK/TaJcl/?	involves: C57BL/6JJcl * KK/TaJcl	MGI:3833452
cx31	a/A^y Guq2^C57BL/6J/Guq2^C57BL/6J	involves: C57BL/6J * KK-A^y	MGI:3773903
cx32	a/A^y Guq1^KK/Guq1^KK	involves: C57BL/6J * KK-A^y	MGI:3773902
cx33	a/A^y Bwq2^KK/Bwq2^KK	involves: C57BL/6J * KK-A^y	MGI:3487268
cx34	a/A^y Zc3h4^C57BL/6J/Zc3h4^KK	involves: C57BL/6J * KK-A^y	MGI:2679981
cx35	a/A^y Bwq10^C57BL/6J/Bwq10^C57BL/6J	involves: C57BL/6J * KK-A^y	MGI:3773901
cx36	a/A^y Zc3h4^KK/Zc3h4^KK	involves: C57BL/6J * KK-A^y	MGI:2679980
cx37	A^y/a Rmi1^{Gt(pUHachi)0283Imeg}/Rmi1⁺	involves: C57BL/6 * KK	MGI:4936833
cx38	A^y/a Tg(tetO-Ppargc1a)1Dpk/0 Tg(Tyr-rtTA)37Lc/0	involves: FVB	MGI:6259414
cx39	A^y/a Dmbx1^tm1Sse/Dmbx1^tm1Sse	involves: ICR	MGI:3759412
cx40	A^y/a Tyrp1^B-lt/?	Not Specified	MGI:3795189
cx41	A^y/a Ednrb^s/Ednrb^s	Not Specified	MGI:5086233

Allelic Composition	A^y/A^y
Genetic Background	101-A^y

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A^y mutation (12 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:174504 )

embryonic lethality at implantation, complete penetrance ( J:174504 )

• putative homozygous embryos appear as small masses of vacuolated cells in decidual crypts at the time normal embryos are implanting; the abnormal embryo is resorbed within 36 hours

• Background Sensitivity: the genotype of the mother, with or without A^y, determines if a homozygous embryo dies at the initial stage of implantation or after the process begins

cellular

maternal effect ( J:174504 )

• introducing homozygous A^y embryos into the uterus of a wild-type mouse delays embryonic death until after implantation begins

• there are approximately twice the number of cells, development of a small ectoplacental cone and Reichert's membrane, and disintegration of the decidual epithelium characteristic of an advanced implantation site

Allelic Composition	A^y/A^w
Genetic Background	129S1.C3-A^y/A^w Chr 19^MOLF/Ei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A^w mutation (14 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of induced tumors ( J:146879 )

• incidence of testicular germ cell tumors is decreased 24% compared to in 129S1/SvImJ-Chr 19/Na mice

growth/size/body

increased body weight ( J:146879 )

Allelic Composition	A^y/a
Genetic Background	B6.Cg-A^y/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

A^y/a mouse

behavior/neurological

abnormal food intake ( J:102986 )

• the stress of isolation, restraint, or ip injection inhibits feeding

pigmentation

abnormal hair follicle melanogenesis ( J:1295 )

• tyrosinase levels in hairbulb melanocytes ,as determined by 35S methionine incorporation and immunotitration, are reduced in comparison to a/a controls

• decreased tyrosinase suggests the production of predominantly phaeomelanin (yellow)

integument

abnormal hair follicle melanogenesis ( J:1295 )

• tyrosinase levels in hairbulb melanocytes ,as determined by 35S methionine incorporation and immunotitration, are reduced in comparison to a/a controls

• decreased tyrosinase suggests the production of predominantly phaeomelanin (yellow)

Allelic Composition	A^y/A
Genetic Background	involves: C3H/HeJ * C57BL/6J-A^y/a

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

yellow coat color ( J:30778 )

pigmentation

yellow coat color ( J:30778 )

Allelic Composition	A^y/A
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased brown adipose tissue amount ( J:131039 )

• female mice have a 6-fold gain in weight of BAT compared to littermate controls

increased gonadal fat pad weight ( J:131039 )

• female mice have almost a 7-fold gain in weight of fat pad

increased inguinal fat pad weight ( J:131039 )

• female mice have a greater than 6-fold gain in weight of fat pad

increased retroperitoneal fat pad weight ( J:131039 )

• female mice have almost a 6-fold gain in weight of fat pad

increased percent body fat/body weight ( J:131039 )

• female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls

• male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls

behavior/neurological

increased food intake ( J:131039 )

• 18 week old mice eat about 1.4 times more food during a 7 day period compared to wild-type controls

decreased locomotor activity ( J:131039 )

• the locomotor activity of mice is about half that of wild-type mice

growth/size/body

obese ( J:131039 )

• by 23 weeks of age, female mice have almost double the weight compared to their wild-type littermate controls

increased body length ( J:131039 )

• female but not male mice have a significant 5% increase in their body length

increased susceptibility to weight gain ( J:131039 )

• mice gain weight at a greater rate than littermate controls starting at six weeks of age

increased liver weight ( J:131039 )

• female mice have almost a 2-fold gain in weight of the liver

homeostasis/metabolism

increased circulating leptin level ( J:131039 )

• circulating levels of leptin are over 12-fold higher compared to littermate controls

liver/biliary system

increased liver weight ( J:131039 )

• female mice have almost a 2-fold gain in weight of the liver

pigmentation

yellow coat color ( J:131039 )

• mice have a yellow coat color

integument

yellow coat color ( J:131039 )

• mice have a yellow coat color

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:131039

Allelic Composition	A^y/a
Genetic Background	involves: KK

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:26460 )

• blood glucose levels increase with age in both sexes

• marked hyperglycemia (400-500 mg/dl) develops by 16 weeks of age

increased circulating insulin level ( J:26460 )

• markedly elevated plasma immunoreactive insulin (IRI) level increases with age

impaired glucose tolerance ( J:26460 )

increased urine glucose level ( J:26460 )

• present at all ages tested (5, 10, 16 weeks) and in both sexes

insulin resistance ( J:26460 )

• insulin sensitivity is impaired at 10 weeks and lost by 16 weeks

abnormal lipid homeostasis ( J:26460 )

• lipogenesis from acetate is elevated at 5 weeks of age, the enhanced activity is maintained until 16 weeks of age

• the acetate/glucose ratio is higher than control in young mice

adipose tissue

increased total body fat amount ( J:26460 )

• adipose tissue weight increases with age, reaching a maximum at 10 weeks of age

growth/size/body

increased susceptibility to weight gain ( J:26460 )

• greater body weight gain occurs in females as compared to black KK controls

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:26460 )

• islets are hypertrophic in 10-16 week old mice

• central cavity formation with occasional red blood cells is observed in islets

degranulated pancreatic beta cells ( J:26460 )

• beta cells are degranulated

• degranulated islets are infiltrated with fine glycogen granules

renal/urinary system

increased urine glucose level ( J:26460 )

• present at all ages tested (5, 10, 16 weeks) and in both sexes

increased renal glomerulus basement membrane thickness ( J:26460 )

• basement membrane of Bowman's capsules is thickened

abnormal renal glomerulus morphology ( J:26460 )

• some glomeruli exhibit an accumulation of eosinophilic material in the outer parts of the capillary

expanded mesangial matrix ( J:26460 )

• mesangial matrix is thickened

abnormal renal tubule morphology ( J:26460 )

• basement membrane of tubules is thickened

• hyaline materials or hyaline cast is present in tubules

dilated renal tubule ( J:26460 )

renal cast ( J:26460 )

• hyaline materials or hyaline cast is present in tubules

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:26460

Allelic Composition	A^y/a Sik2^tm1Htake/Sik2⁺
Genetic Background	C57BL/6-Sik2^tm1Htake

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Sik2^tm1Htake mutation (0 available); any Sik2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

darkened coat color ( J:215877 )

• slightly darker than in A^y/a mice on the dorsal region

• darker ventral region hair compared with A^y/a mice

pigmentation

darkened coat color ( J:215877 )

• slightly darker than in A^y/a mice on the dorsal region

• darker ventral region hair compared with A^y/a mice

Allelic Composition	A^y/a Apoe^tm1Unc/Apoe^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)
A^y mutation (12 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:177084 )

• mutants develop larger atherosclerotic plaques than a/a Apoe^tm1Unc/Apoe^tm1Unc mice

• plaques contain a higher proportion of macrophage infiltration

growth/size/body

obese ( J:177084 )

• mutants exhibit increased weight gain, despite similar food intake as controls

hematopoietic system

increased monocyte cell number ( J:177084 )

• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads

homeostasis/metabolism

hyperglycemia ( J:177084 )

increased circulating insulin level ( J:177084 )

increased circulating leptin level ( J:177084 )

increased circulating cholesterol level ( J:177084 )

increased circulating triglyceride level ( J:177084 )

insulin resistance ( J:177084 )

decreased circulating adiponectin level ( J:177084 )

immune system

increased monocyte cell number ( J:177084 )

• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads

abnormal inflammatory response ( J:177084 )

• increase in systemic inflammation

renal/urinary system

abnormal kidney morphology ( J:177084 )

• mutants develop features of diabetic nephropathy

abnormal glomerular mesangium morphology ( J:177084 )

• mutants exhibit mesangial expansion as indicated by glycogen deposition in the glomeruli

glomerulosclerosis ( J:177084 )

• 20-30% of mutants exhibit nodular sclerosis in the kidney

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
abdominal obesity-metabolic syndrome		DOID:0060611	OMIM:PS605552	J:177084

Allelic Composition	A^y/a Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Mae/Ccr2^tm1Mae
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:177084 )

N	• mutants are protected against the metabolic syndrome, atherosclerosis, and diabetic nephropathy that develops in A^y/a Apoe^tm1Unc double mutants

increased circulating leptin level ( J:177084 )

increased circulating cholesterol level ( J:177084 )

decreased circulating adiponectin level ( J:177084 )

Allelic Composition	A^y/a Npbwr1^tm1Rck/Npbwr1^tm1Rck
Genetic Background	involves: 129P/Ola * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Npbwr1^tm1Rck mutation (0 available); any Npbwr1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:94820 )

• male double homozygotes were more obese than heterozygous A^y males whereas females weighted the same as heterozygous A^y females

Allelic Composition	A^y/a Agrp^{tm2(HBEGF)Rpa}/Agrp⁺
Genetic Background	involves: 129S4/SvJaeSor * KK/Upj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (18 available)
A^y mutation (12 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal eating behavior ( J:132184 )

• in mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells

growth/size/body

decreased body weight ( J:132184 )

• in mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells

Allelic Composition	A^y/A Pepd^dal/Pepd^dal
Genetic Background	involves: C3H/HeJ * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Pepd^dal mutation (1 available); any Pepd mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

darkened coat color ( J:143333 )

• dark-like homozygotes heterozygous for yellow have much darker dorsal hair than mice heterozygous for both mutations, placing dark-like downstream of agouti transcription

pigmentation

darkened coat color ( J:143333 )

• dark-like homozygotes heterozygous for yellow have much darker dorsal hair than mice heterozygous for both mutations, placing dark-like downstream of agouti transcription

growth/size/body

obese ( J:143333 )

• mice heterozygous for yellow are obese and longer than normal to the same degree regardless of being wild-type or homozygous for dark-like

Allelic Composition	A^y/A Prkar2b^tm2Gsm/Prkar2b^tm2Gsm
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased brown adipose tissue amount ( J:131039 )

• female mice have a 2-fold gain in mg of BAT compared to littermate controls

increased gonadal fat pad weight ( J:131039 )

• female mice have almost a 2-fold increase in fat pad weight compared to wild-type controls

increased inguinal fat pad weight ( J:131039 )

• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls

increased retroperitoneal fat pad weight ( J:131039 )

• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls

increased percent body fat/body weight ( J:131039 )

• female and male mice have a 1.6-fold gain in percentage of body fat compared to littermate controls

behavior/neurological

behavior/neurological phenotype ( J:131039 )

N	• food consumption and circulating levels of leptin are close to wild-type levels, which is significantly less compared to mice with only the A^y mutant allele

increased locomotor activity ( J:131039 )

• locomotor activity is about 1.5-fold higher compared to wild-type control mice

growth/size/body

growth/size/body region phenotype ( J:131039 )

• mean body weight and length of 20-23 week old mice is similar to wild-type littermate controls and is less than is observed in mice with only the A^y mutant allele

• weight and percentage of body fat in female mice is higher than in wild-type mice but is significantly lower than is observed in mice with only the A^y mutant allele

increased susceptibility to weight gain ( J:131039 )

• male but not female mice gain weight at a greater rate than littermate controls starting at six weeks of age

• rate of weight gain in male mice is significantly less than in A^y heterozygotes

pigmentation

yellow coat color ( J:131039 )

• mice have a yellow coat color

integument

yellow coat color ( J:131039 )

• mice have a yellow coat color

Allelic Composition	A^y/A Prkar2b^tm2Gsm/Prkar2b⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased percent body fat/body weight ( J:131039 )

• mice have increased percentage of body fat but is 10% less than what is observed in A^y heterozygotes

behavior/neurological

polyphagia ( J:131039 )

• mice have a higher food consumption but is about 10% less than the amount A^y heterozygotes consume

growth/size/body

increased susceptibility to weight gain ( J:131039 )

• mice have increased rate of weight growth compared to wild-type mice but significantly less than in A^y heterozygotes

Allelic Composition	A^y/a Mssq6^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq6^KK/TaJcl mutation (0 available); any Mssq6 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq5^C57BL/6JJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq5^C57BL/6JJcl mutation (0 available); any Mssq5 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq6^C57BL/6JJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq6^C57BL/6JJcl mutation (0 available); any Mssq6 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased values for principal component analysis of mandible size

skeleton

large mandible ( J:143893 )

• increased values for principal component analysis of mandible size

Allelic Composition	A^y/a Mssq7^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq7^KK/TaJcl mutation (0 available); any Mssq7 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq9^C57BL/6JJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq9^C57BL/6JJcl mutation (0 available); any Mssq9 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq10^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq10^KK/TaJcl mutation (0 available); any Mssq10 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq11^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq11^KK/TaJcl mutation (0 available); any Mssq11 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased values for principal component analysis of mandible size measurements

skeleton

large mandible ( J:143893 )

• increased values for principal component analysis of mandible size measurements

Allelic Composition	A^y/a Mssq12^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq12^KK/TaJcl mutation (0 available); any Mssq12 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased values for principal component analysis of mandible size measurements

skeleton

large mandible ( J:143893 )

• increased values for principal component analysis of mandible size measurements

Allelic Composition	A^y/a Mssq13^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq13^KK/TaJcl mutation (0 available); any Mssq13 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased values for principal component analysis of mandible size measurements

skeleton

large mandible ( J:143893 )

• increased values for principal component analysis of mandible size measurements

Allelic Composition	A^y/a Mssq13^C57BL/6JJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq13^C57BL/6JJcl mutation (0 available); any Mssq13 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq14^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq14^KK/TaJcl mutation (0 available); any Mssq14 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

• increased values for principal component analysis of mandible size measurements

skeleton

large mandible ( J:143893 )

• increased mandible size

• increased values for principal component analysis of mandible size measurements

Allelic Composition	A^y/a Mssq16^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq16^KK/TaJcl mutation (0 available); any Mssq16 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq1^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq1^KK/TaJcl mutation (0 available); any Mssq1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq2^C57BL/6JJcl/Mssq2^KK/TaJcl
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq2^C57BL/6JJcl mutation (0 available); any Mssq2 mutation (0 available)
Mssq2^KK/TaJcl mutation (0 available); any Mssq2 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq3^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq3^KK/TaJcl mutation (0 available); any Mssq3 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	A^y/a Mssq4^KK/TaJcl/?
Genetic Background	involves: C57BL/6JJcl * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Mssq4^KK/TaJcl mutation (0 available); any Mssq4 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

large mandible ( J:143893 )

• increased mandible size

skeleton

large mandible ( J:143893 )

• increased mandible size

Allelic Composition	a/A^y Guq2^C57BL/6J/Guq2^C57BL/6J
Genetic Background	involves: C57BL/6J * KK-A^y

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Guq2^C57BL/6J mutation (0 available); any Guq2 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine glucose level ( J:131439 )

• increased glucosuria severity at 40 days of age

renal/urinary system

increased urine glucose level ( J:131439 )

• increased glucosuria severity at 40 days of age

Allelic Composition	a/A^y Guq1^KK/Guq1^KK
Genetic Background	involves: C57BL/6J * KK-A^y

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Guq1^KK mutation (0 available); any Guq1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine glucose level ( J:131439 )

• increased glucosuria severity at 40 days of age

renal/urinary system

increased urine glucose level ( J:131439 )

• increased glucosuria severity at 40 days of age

Allelic Composition	a/A^y Bwq2^KK/Bwq2^KK
Genetic Background	involves: C57BL/6J * KK-A^y

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Bwq2^KK mutation (0 available); any Bwq2 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:93199 , J:131439 )

• increased body weight at 40-100 days of age (J:93199)

• increased body weight at 40, 50, and 60 days of age (J:131439)

increased susceptibility to weight gain ( J:93199 )

• increased weight gain at 30-40 days of age

Allelic Composition	a/A^y Zc3h4^C57BL/6J/Zc3h4^KK
Genetic Background	involves: C57BL/6J * KK-A^y

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Zc3h4^C57BL/6J mutation (0 available); any Zc3h4 mutation (177 available)
Zc3h4^KK mutation (0 available); any Zc3h4 mutation (177 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:48704 )

• increased body weight

Allelic Composition	a/A^y Bwq10^C57BL/6J/Bwq10^C57BL/6J
Genetic Background	involves: C57BL/6J * KK-A^y

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Bwq10^C57BL/6J mutation (0 available); any Bwq10 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:131439 )

• increased body weight at 40, 50, and 60 days of age

Allelic Composition	a/A^y Zc3h4^KK/Zc3h4^KK
Genetic Background	involves: C57BL/6J * KK-A^y

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Zc3h4^KK mutation (0 available); any Zc3h4 mutation (177 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:48704 , J:131439 )

Allelic Composition	A^y/a Rmi1^{Gt(pUHachi)0283Imeg}/Rmi1⁺
Genetic Background	involves: C57BL/6 * KK

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Rmi1^{Gt(pUHachi)0283Imeg} mutation (0 available); any Rmi1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:168271 )

• compared with A^y/a mice

homeostasis/metabolism

decreased circulating glucose level ( J:168271 )

• compared with A^y/a mice

improved glucose tolerance ( J:168271 )

• compared with A^y/a mice

behavior/neurological

abnormal eating behavior ( J:168271 )

• compared with A^y/a mice

liver/biliary system

decreased liver weight ( J:168271 )

• compared with A^y/a mice

adipose tissue

adipose tissue phenotype ( J:168271 )

N	• mice exhibit normal intra-abdominal fat

Allelic Composition	A^y/a Tg(tetO-Ppargc1a)1Dpk/0 Tg(Tyr-rtTA)37Lc/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Tg(tetO-Ppargc1a)1Dpk mutation (1 available)
Tg(Tyr-rtTA)37Lc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

darkened coat color ( J:194191 )

• upon induction of Ppargc1a expression in melanocytes, mice exhibit a noticeably darkened coat color relative to the yellow coat color of A^y/a Tg(Tyr-rtTA)37Lc/0 mice; however, the coat color does not become completely black

abnormal hair follicle melanogenesis ( J:194191 )

• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to A^y/a Tg(Tyr-rtTA)37Lc/0 mice

integument

darkened coat color ( J:194191 )

abnormal hair follicle melanogenesis ( J:194191 )

• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to A^y/a Tg(Tyr-rtTA)37Lc/0 mice

Allelic Composition	A^y/a Dmbx1^tm1Sse/Dmbx1^tm1Sse
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Dmbx1^tm1Sse mutation (0 available); any Dmbx1 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:125193 )

• unlike A^y/a mice, the body weight of double homozygotes is similar to that of Dmbx1^tm1Sse homozygotes

Allelic Composition	A^y/a Tyrp1^B-lt/?
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Tyrp1^B-lt mutation (4 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

yellow coat color ( J:13094 )

• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation

integument

yellow coat color ( J:13094 )

Allelic Composition	A^y/a Ednrb^s/Ednrb^s
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Ednrb^s mutation (19 available); any Ednrb mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

variable body spotting ( J:12954 )

• less white spotting is seen in mice of this genotype than in mice without A^y

• a modifier of the amount of white spotting in heterozygous Kit mice was determined to reduce white spotting in heterozygous A^y mice

pigmentation

variable body spotting ( J:12954 )

• less white spotting is seen in mice of this genotype than in mice without A^y

• a modifier of the amount of white spotting in heterozygous Kit mice was determined to reduce white spotting in heterozygous A^y mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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