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Sox10 Gene Detail
Summary
  • Symbol
    Sox10
  • Name
    SRY (sex determining region Y)-box 10
  • Synonyms
    gt, Sox21
Location &
Maps
more
  • Sequence Map
    Chr15:79039113-79048690 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98358
 protein coding gene Chr15:79039108-79049440 (-)
129S1/SvImJ ENSMUSG00200048634
 protein coding gene Chr15:76151628-76161959 (-)
A/J ENSMUSG00195048403
 protein coding gene Chr15:76092704-76103072 (-)
AKR/J ENSMUSG00220047000
 protein coding gene Chr15:76136117-76146485 (-)
BALB/cJ ENSMUSG00180047734
 protein coding gene Chr15:75969693-75980061 (-)
C3H/HeJ ENSMUSG00175047566
 protein coding gene Chr15:76280965-76291333 (-)
C57BL/6NJ ENSMUSG00215052524
 protein coding gene Chr15:76049441-76059773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020007
 protein coding gene Chr15:73151250-73160616 (-)
CAST/EiJ ENSTCUG00005039173
 protein coding gene Chr15:75592918-75603209 (-)
CBA/J ENSMUSG00210036207
 protein coding gene Chr15:76056100-76066468 (-)
DBA/2J ENSMUSG00185040187
 protein coding gene Chr15:76065983-76076350 (-)
FVB/NJ ENSMUSG00205034421
 protein coding gene Chr15:75785814-75796181 (-)
JF1/MsJ ENSUMUG00000049567
 protein coding gene Chr15:75643770-75654135 (-)
LP/J ENSMUSG00230049993
 protein coding gene Chr15:79400055-79410386 (-)
NOD/ShiLtJ ENSMUSG00190035717
 protein coding gene Chr15:76077509-76087840 (-)
NZO/HlLtJ ENSMUSG00225049136
 protein coding gene Chr15:79728961-79739289 (-)
PWK/PhJ ENSLUMG00010051761
 protein coding gene Chr15:75863451-75873812 (-)
SPRET/EiJ ENSMSPG00010049509
 protein coding gene Chr15:77530233-77539692 (-)
WSB/EiJ ENSIUOG00005049154
 protein coding gene Chr15:76133249-76143577 (-)



Homology
more
  • Human Ortholog
    SOX10, SRY-box transcription factor 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX10, SRY-box transcription factor 10
  • Synonyms
    DOM, PCWH, SOX-10, WS2E, WS4, WS4C
  • Links
    NCBI Gene ID: 6663
    UniProt: P56693

  • Chr Location
    22q13.1; chr22:37970686-37987422 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Sox10 mouse models; 4 with human SOX10 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    100 phenotypes from 14 alleles in 24 genetic backgrounds
    40 phenotypes from multigenic genotypes
    7 images
    172 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations lack peripheral glial cells, melanocytes, and autonomic and enteric neurons, and die neonatally or sooner. Heterozygotes exhibit white spotting and megacolon.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2782
  • Tissues
    650
  • cDNA Data
    175
  • Literature Summary
    664
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20665 NCBI Gene Model | MGI Sequence Detail 9578 C57BL/6J ±  kb
    transcript NM_011437 RefSeq | MGI Sequence Detail 2713 ZRU/MplStud  
    polypeptide Q04888 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 256
      Genomic 7
      cDNA 182
      Primer pair 19
      Other 48
      Antibodies 42

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10325, MGD-MRK-14497, MGD-MRK-38228, MGD-MRK-8879, MGI:109184, MGI:94914, MGI:95866
    References
    more
    • Summaries
      All 889
      Developmental Gene Expression 664
      Diseases 4
      Gene Ontology 27
      Phenotypes 172
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:391384 Ishimoto Y, et al., Deletion of ARPKD-associated Pkhd1 gene in mice results in decreased Tfap2b expression and eye abnormalities. Nat Commun. 2026 Jul 23;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory