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Stmn2 Gene Detail
Summary
  • Symbol
    Stmn2
  • Name
    stathmin-like 2
  • Synonyms
    SCG10, Scgn10
  • Feature Type
    protein coding gene
  • IDs
    MGI:98241
    NCBI Gene: 20257
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:8574587-8626664 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 2.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1402 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98241
 protein coding gene Chr3:8574420-8626666 (+)
129S1/SvImJ ENSMUSG00200000728
 protein coding gene Chr3:5237418-5289845 (+)
A/J ENSMUSG00195001178
 protein coding gene Chr3:5579513-5631933 (+)
AKR/J ENSMUSG00220017014
 protein coding gene Chr3:5580087-5632496 (+)
BALB/cJ ENSMUSG00180006869
 protein coding gene Chr3:5591136-5643544 (+)
C3H/HeJ ENSMUSG00175004967
 protein coding gene Chr3:5588071-5640480 (+)
C57BL/6NJ ENSMUSG00215005291
 protein coding gene Chr3:5603103-5655525 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024831
 protein coding gene Chr3:4597251-4645452 (+)
CAST/EiJ ENSTCUG00005000199
 protein coding gene Chr3:5648293-5698624 (+)
CBA/J ENSMUSG00210000636
 protein coding gene Chr3:5573241-5625652 (+)
DBA/2J ENSMUSG00185000483
 protein coding gene Chr3:5582932-5635323 (+)
FVB/NJ ENSMUSG00205005884
 protein coding gene Chr3:5403649-5456050 (+)
JF1/MsJ ENSUMUG00000008666
 protein coding gene Chr3:5460237-5510647 (+)
LP/J ENSMUSG00230000084
 protein coding gene Chr3:7498454-7550879 (+)
NOD/ShiLtJ ENSMUSG00190022561
 protein coding gene Chr3:5673229-5725628 (+)
NZO/HlLtJ ENSMUSG00225000384
 protein coding gene Chr3:10071596-10124036 (+)
PWK/PhJ ENSLUMG00010008159
 protein coding gene Chr3:5519023-5569436 (+)
SPRET/EiJ ENSMSPG00010000087
 protein coding gene Chr3:5427546-5478002 (+)
WSB/EiJ ENSIUOG00005000694
 protein coding gene Chr3:5593867-5646300 (+)



Homology
more
  • Human Ortholog
    STMN2, stathmin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STMN2, stathmin 2
  • Synonyms
    SCG10, SCGN10
  • Links
    NCBI Gene ID: 11075
    UniProt: Q93045

  • Chr Location
    8q21.13; chr8:79611117-79666159 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Stmn2 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 2 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop early-onset sensory and motor neuropathy with behavioral deficits, reduced compound muscle action potentials, severe distal neuromuscular junction (NMJ) denervation of fast-fatigable motor units, and intraepidermal nerve fiber loss. Heterozygous null mice show a progressive, motor-selective neuropathy with distal NMJ denervation but no sensory defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1080
  • Tissues
    152
  • cDNA Data
    170
  • Literature Summary
    95
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20257 NCBI Gene Model | MGI Sequence Detail 52078 C57BL/6J ±  kb
    transcript NM_025285 RefSeq | MGI Sequence Detail 1904 ZRU/MplStud  
    polypeptide P55821 UniProt | EBI | MGI Sequence Detail 179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 208
      Genomic 16
      cDNA 176
      Primer pair 2
      Other 14
      Antibodies 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14310, MGI:2139640
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 95
      Diseases 1
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:2523 Pampfer S, et al., Differential mRNA expression of the phosphoprotein p19/SCG10 gene family in mouse preimplantation embryos, uterus, and placenta. Reprod Fertil Dev. 1992;4(2):205-11
    • Latest
      J:379202 Desiderio S, et al., Expression dynamics of functionally equivalent Neurog1/2 genes enable protracted neurogenesis and temporal emergence of somatosensory neuron lineages. Cell Rep. 2026 Jan 27;45(1):116798
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory