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Mc3r Gene Detail
Summary
  • Symbol
    Mc3r
  • Name
    melanocortin 3 receptor
Location &
Maps
more
  • Sequence Map
    Chr2:172090412-172093034 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 94.80 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96929
 protein coding gene Chr2:172090412-172093034 (+)
129S1/SvImJ ENSMUSG00200040032
 protein coding gene Chr2:169015137-169017763 (+)
A/J ENSMUSG00195023638
 protein coding gene Chr2:169343415-169346041 (+)
AKR/J ENSMUSG00220033481
 protein coding gene Chr2:168639180-168641806 (+)
BALB/cJ ENSMUSG00180031370
 protein coding gene Chr2:168788853-168791471 (+)
C3H/HeJ ENSMUSG00175038884
 protein coding gene Chr2:169558603-169561221 (+)
C57BL/6NJ ENSMUSG00215021164
 protein coding gene Chr2:168981112-168983734 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024733
 protein coding gene Chr2:164192093-164194788 (+)
CAST/EiJ ENSTCUG00005008190
 protein coding gene Chr2:167882632-167885256 (+)
CBA/J ENSMUSG00210039824
 protein coding gene Chr2:169468886-169471504 (+)
DBA/2J ENSMUSG00185024471
 protein coding gene Chr2:169182225-169184843 (+)
FVB/NJ ENSMUSG00205015441
 protein coding gene Chr2:168231520-168234137 (+)
JF1/MsJ ENSUMUG00000034987
 protein coding gene Chr2:168870520-168873142 (+)
LP/J ENSMUSG00230009299
 protein coding gene Chr2:170751614-170754236 (+)
NOD/ShiLtJ ENSMUSG00190037489
 protein coding gene Chr2:168869669-168872295 (+)
NZO/HlLtJ ENSMUSG00225003006
 protein coding gene Chr2:178744852-178747470 (+)
PWK/PhJ ENSLUMG00010032555
 protein coding gene Chr2:168759271-168761900 (+)
SPRET/EiJ ENSMSPG00010024529
 protein coding gene Chr2:171514721-171516378 (+)
WSB/EiJ ENSIUOG00005022115
 protein coding gene Chr2:168612385-168615007 (+)



Homology
more
  • Human Ortholog
    MC3R, melanocortin 3 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MC3R, melanocortin 3 receptor
  • Synonyms
    BMIQ9, MC3, MC3-R, OB20, OQTL
  • Links
    NCBI Gene ID: 4159
    UniProt: P41968

  • Chr Location
    20q13.2; chr20:56248732-56249815 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mc3r mouse models; 1 with human MC3R associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 5 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele exhibit obesity, increased respiratory quotient on a high fat diet, and reduced energy expenditure. Homozygotes for another null allele show reduced lean mass, increased fat mass, diet-induced obesity, increased insulin and leptin levels, and reduced energy expenditure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    643
  • Tissues
    39
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17201 NCBI Gene Model | MGI Sequence Detail 2623 C57BL/6J ±  kb
    transcript NM_008561 RefSeq | MGI Sequence Detail 2623 ZRU/MplStud  
    polypeptide P33033 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 3
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12131
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 10
      Phenotypes 55
    • Earliest
      J:17785 Desarnaud F, et al., Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene. Biochem J. 1994 Apr 15;299(Pt 2):367-73
    • Latest
      J:384159 Duckett K, et al., Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance. Mol Metab. 2026 Jan;103:102301
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory