Phenotypes Associated with This Genotype

Genotype
MGI:3639354

• Allelic Composition: Mc3r^tm1Cone/Mc3r^tm1Cone
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:78132 )

• female null mice are significantly heavier than wild-type around 50-60 days of age

obese ( J:78132 )

• mutants are obese with the proportion of fat increasing by ~40% around 15-20 weeks of age compared to wild-type (31.8% in wild-type vs 45.2% in Mc3r-null mice)

homeostasis/metabolism

abnormal respiratory quotient ( J:78132 )

• mice show a trend toward greater oxygen consumption on low or high fat diets compared to wild-type

• when switched to high fat chow, mutants show a dramatic increase in respiratory quotient 24 hours after the switch

• mutants show a reduced RQ compared to wild-type on a low fat chow diet and a higher RQ on high fat chow

behavior/neurological

abnormal food intake ( J:78132 )

• despite increased body fat, mice do not exhibit weight gain or increased food consumption

adipose tissue

increased total body fat amount ( J:78132 )

• on a low-fat chow, mutants show increased fat content without gross weight being different

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:78132