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Krt18 Gene Detail
Summary
  • Symbol
    Krt18
  • Name
    keratin 18
  • Synonyms
    CK18, Endo B, K18, Krt1-18
  • Feature Type
    protein coding gene
  • IDs
    MGI:96692
    NCBI Gene: 16668
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101936651-101940461 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.22 cM, cytoband F3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96692
 protein coding gene Chr15:101936615-101940462 (+)
129S1/SvImJ ENSMUSG00200049352
 protein coding gene Chr15:99162264-99166117 (+)
A/J ENSMUSG00195037147
 protein coding gene Chr15:99052140-99055984 (+)
AKR/J ENSMUSG00220045895
 protein coding gene Chr15:99022065-99025916 (+)
BALB/cJ ENSMUSG00180041876
 protein coding gene Chr15:98934083-98937942 (+)
C3H/HeJ ENSMUSG00175039782
 protein coding gene Chr15:99254067-99257910 (+)
C57BL/6NJ ENSMUSG00215049238
 protein coding gene Chr15:98977536-98981392 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020334
 protein coding gene Chr15:95865280-95869041 (+)
CAST/EiJ ENSTCUG00005046121
 protein coding gene Chr15:98459603-98463435 (+)
CBA/J ENSMUSG00210025655
 protein coding gene Chr15:99005245-99009088 (+)
DBA/2J ENSMUSG00185034222
 protein coding gene Chr15:99021983-99025832 (+)
FVB/NJ ENSMUSG00205023020
 protein coding gene Chr15:98726479-98730329 (+)
JF1/MsJ ENSUMUG00000025376
 protein coding gene Chr15:98482446-98486277 (+)
LP/J ENSMUSG00230035935
 protein coding gene Chr15:102383344-102387193 (+)
NOD/ShiLtJ ENSMUSG00190042077
 protein coding gene Chr15:98966836-98970685 (+)
NZO/HlLtJ ENSMUSG00225026852
 protein coding gene Chr15:102563345-102567197 (+)
PWK/PhJ ENSLUMG00010044672
 protein coding gene Chr15:98694854-98698683 (+)
SPRET/EiJ ENSMSPG00010045075
 protein coding gene Chr15:100484033-100487850 (+)
WSB/EiJ ENSIUOG00005030099
 protein coding gene Chr15:99112633-99116470 (+)



Homology
more
  • Human Ortholog
    KRT18, keratin 18
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT18, keratin 18
  • Synonyms
    CK-18, CYK18, K18
  • Links
    NCBI Gene ID: 3875
    UniProt: P05783

  • Chr Location
    12q13.13; chr12:52945688-52952911 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Krt18 mouse models; 1 with human KRT18 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are viable, fertile, and live normal life spans. They do, however, develop hepatomegaly by 18 months of age. Aged mice develop liver lesions resembling steatohepatitis and eventually liver tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1201
  • Tissues
    263
  • cDNA Data
    490
  • Literature Summary
    137
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16668 NCBI Gene Model | MGI Sequence Detail 3811 C57BL/6J ±  kb
    transcript NM_010664 RefSeq | MGI Sequence Detail 1400 ZRU/MplStud  
    polypeptide P05784 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009458 keratin, type I cytoskeletal 18
      (term hierarchy)
    • InterPro Domains
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR002957 Keratin, type I
    • GlyGen
      P05784 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 511
      Genomic 6
      cDNA 493
      Primer pair 10
      Other 2
      Antibodies 21

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11647
    References
    more
    • Summaries
      All 232
      Developmental Gene Expression 137
      Diseases 2
      Gene Ontology 14
      Phenotypes 47
    • Earliest
      J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory