Analysis Tools
liver/biliary system
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• focal hemorrhagic parenchymal necrosis
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• apoptotic bodies are more frequent in livers of male mice
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• mild lobular inflammatory activity with foci of mononuclear cells
• mild portal mononuclear cell infiltrate surrounding interlobular bile ducts
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• 17-20-month-old mice develop liver lesions resembling steatohepatitis
• however, no liver fibrosis is seen
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• focal necrosis of hepatocytes
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• focal hemorrhagic parenchymal necrosis, surrounded and penetrated by neutrophils
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• aged mice exhibit hepatocyte anisocytosis and anisokaryosis
• hepatocytes show cleared-out cytoplasm in aged mice
• mice sow disseminated single hepatocytes containing erythrocytes, as well as syncytial parenchymal areas with nuclear crowding
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• Mallory-Denk bodies (MDBs) appear as irregularly shaped dense eosinophilic cytoplasmic clumps and granules in ballooned hepatocytes, predominantly in perivenular position
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• mild to moderate liver steatosis in the majority of mice; fatty change as multiple small and medium-sized cytoplasmic vesicles with gradual coalescence to larger vesicles toward the lobular periphery
• rarely, MDB-containing hepatocytes are surrounded by neutrophils and mononuclear cells
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• approximately 80% of male and 35% of females develop liver tumors, with mice developing multiple tumors; distinct non-encapsulated nodules with expanding growth leading to compression of the surrounding parenchyma, and irregular arrangement and morphology of tumor cells
• pleomorphic tumors are more frequent than monomorphic and more prevalent in males than females
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• tumors in aged mice closely resemble human hepatocellular carcinoma in their genetic profile
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neoplasm
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• approximately 80% of male and 35% of females develop liver tumors, with mice developing multiple tumors; distinct non-encapsulated nodules with expanding growth leading to compression of the surrounding parenchyma, and irregular arrangement and morphology of tumor cells
• pleomorphic tumors are more frequent than monomorphic and more prevalent in males than females
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• tumors in aged mice closely resemble human hepatocellular carcinoma in their genetic profile
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cellular
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• apoptotic bodies are more frequent in livers of male mice
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• focal necrosis of hepatocytes
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• mice show chromosomal instability in liver at 12 months of age, before tumor formation
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immune system
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• mild lobular inflammatory activity with foci of mononuclear cells
• mild portal mononuclear cell infiltrate surrounding interlobular bile ducts
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cardiovascular system
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• focal hemorrhagic parenchymal necrosis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:309021 | |
| metabolic dysfunction-associated steatohepatitis | DOID:0080547 | J:309021 | ||
