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Ephx1 Gene Detail
Summary
  • Symbol
    Ephx1
  • Name
    epoxide hydrolase 1, microsomal
  • Synonyms
    Eph-1, Eph1, mEH
  • Feature Type
    protein coding gene
  • IDs
    MGI:95405
    NCBI Gene: 13849
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:180817121-180845134 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.48 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    947 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95405
 protein coding gene Chr1:180803775-180848469 (-)
129S1/SvImJ ENSMUSG00200021644
 protein coding gene Chr1:178557659-178602351 (-)
A/J ENSMUSG00195038279
 protein coding gene Chr1:178173176-178217731 (-)
AKR/J ENSMUSG00220019158
 protein coding gene Chr1:177409050-177454029 (-)
BALB/cJ ENSMUSG00180033044
 protein coding gene Chr1:178208918-178253606 (-)
C3H/HeJ ENSMUSG00175036231
 protein coding gene Chr1:178384698-178429386 (-)
C57BL/6NJ ENSMUSG00215012178
 protein coding gene Chr1:177609354-177654047 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014988
 protein coding gene Chr1:170842563-170887301 (-)
CAST/EiJ ENSTCUG00005042745
 protein coding gene Chr1:176135622-176179881 (-)
CBA/J ENSMUSG00210018400
 protein coding gene Chr1:178055305-178099999 (-)
DBA/2J ENSMUSG00185034795
 protein coding gene Chr1:182674718-182719409 (-)
FVB/NJ ENSMUSG00205030311
 protein coding gene Chr1:177104616-177149315 (-)
JF1/MsJ ENSUMUG00000014221
 protein coding gene Chr1:181650277-181695153 (-)
LP/J ENSMUSG00230027053
 protein coding gene Chr1:182223161-182267844 (-)
NOD/ShiLtJ ENSMUSG00190027605
 protein coding gene Chr1:178070537-178115218 (-)
NZO/HlLtJ ENSMUSG00225009498
 protein coding gene Chr1:185976215-186021184 (-)
PWK/PhJ ENSLUMG00010015447
 protein coding gene Chr1:176914671-176959254 (-)
SPRET/EiJ ENSMSPG00010030146
 protein coding gene Chr1:180396880-180428636 (-)
WSB/EiJ ENSIUOG00005011392
 protein coding gene Chr1:177283320-177328035 (-)



Homology
more
  • Human Ortholog
    EPHX1, epoxide hydrolase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHX1, epoxide hydrolase 1
  • Synonyms
    EPHX, EPOX, HYL1, MEH
  • Links
    NCBI Gene ID: 2052
    UniProt: P07099

  • Chr Location
    1q42.12; chr1:225810095-225845567 (+)  GRCh38
Human Diseases
more
  • Diseases
    18 with human EPHX1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are highly resistant to DMBA-induced skin carcinogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    109
  • cDNA Data
    167
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13849 NCBI Gene Model | MGI Sequence Detail 28014 C57BL/6J ±  kb
transcript NM_010145 RefSeq | MGI Sequence Detail 1754 C57BL/6  
polypeptide Q9D379 UniProt | EBI | MGI Sequence Detail 455 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 169
    cDNA 168
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9563, MGD-MRK-9564, MGI:2138172
References
more
  • Summaries
    All 73
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:6369 Lyman SD, et al., Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse. J Biol Chem. 1980 Sep 25;255(18):8650-4
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory