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Ywhae Gene Detail
Summary
  • Symbol
    Ywhae
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  • Synonyms
    14-3-3 epsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:894689
    NCBI Gene: 22627
  • Alliance
    genome feature page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75623695-75656671 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.92 cM, cytoband B2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894689
 protein coding gene Chr11:75620121-75656671 (+)
129S1/SvImJ ENSMUSG00200048871
 protein coding gene Chr11:72741457-72774438 (+)
A/J ENSMUSG00195040918
 protein coding gene Chr11:72619860-72652835 (+)
AKR/J ENSMUSG00220043281
 protein coding gene Chr11:72835080-72868059 (+)
BALB/cJ ENSMUSG00180032370
 protein coding gene Chr11:72808295-72841274 (+)
C3H/HeJ ENSMUSG00175038494
 protein coding gene Chr11:72778206-72811183 (+)
C57BL/6NJ ENSMUSG00215037926
 protein coding gene Chr11:72400101-72433077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016748
 protein coding gene Chr11:70667925-70703432 (+)
CAST/EiJ ENSTCUG00005044999
 protein coding gene Chr11:72309204-72342262 (+)
CBA/J ENSMUSG00210039479
 protein coding gene Chr11:72596685-72629663 (+)
DBA/2J ENSMUSG00185034447
 protein coding gene Chr11:72866675-72899653 (+)
FVB/NJ ENSMUSG00205039612
 protein coding gene Chr11:72703301-72736277 (+)
JF1/MsJ ENSUMUG00000051585
 protein coding gene Chr11:73249275-73282233 (+)
LP/J ENSMUSG00230042985
 protein coding gene Chr11:73897296-73930271 (+)
NOD/ShiLtJ ENSMUSG00190045566
 protein coding gene Chr11:72913095-72946070 (+)
NZO/HlLtJ ENSMUSG00225038747
 protein coding gene Chr11:76070888-76103890 (+)
PWK/PhJ ENSLUMG00010020456
 protein coding gene Chr11:72767534-72800485 (+)
SPRET/EiJ ENSMSPG00010042966
 protein coding gene Chr11:73167615-73200541 (+)
WSB/EiJ ENSIUOG00005029859
 protein coding gene Chr11:72767006-72799794 (+)



Homology
more
  • Human Ortholog
    YWHAE, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YWHAE, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  • Synonyms
    14-3-3E, HEL2, KCIP-1, MDCR, MDS
  • Links
    NCBI Gene ID: 7531
    UniProt: P62258

  • Chr Location
    17p13.3; chr17:1344275-1400255 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ywhae mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene usually die around birth. The small percentage of survivors are small in size and display central nervous system abnormalities including a thinner cortex and a disorganized pyramidal cell layer in the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    181
  • cDNA Data
    14
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020849 Ensembl Gene Model | MGI Sequence Detail 32977 C57BL/6J ±  kb
    transcript ENSMUST00000067664 Ensembl | MGI Sequence Detail 2100 Not Applicable  
    polypeptide ENSMUSP00000070993 Ensembl | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 7
      cDNA 14
      Primer pair 5
      Other 1
      Antibodies 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144388
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 24
      Phenotypes 41
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:379462 Li X, et al., 14-3-3epsilon-dependent deubiquitination and translocation of NLRP3 activates the inflammasome during sepsis. JCI Insight. 2026 Jan 9;11(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory