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Frzb Gene Detail
Summary
  • Symbol
    Frzb
  • Name
    frizzled-related protein
  • Synonyms
    fritz, Frp, frzb-1, Sfrp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:892032
    NCBI Gene: 20378
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:80242314-80277740 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 48.13 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    911 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892032
 protein coding gene Chr2:80242314-80277969 (-)
129S1/SvImJ ENSMUSG00200002956
 protein coding gene Chr2:77284905-77320562 (-)
A/J ENSMUSG00195017058
 protein coding gene Chr2:77478830-77514332 (-)
AKR/J ENSMUSG00220001947
 protein coding gene Chr2:77490477-77525974 (-)
BALB/cJ ENSMUSG00180006662
 protein coding gene Chr2:77406710-77442199 (-)
C3H/HeJ ENSMUSG00175010140
 protein coding gene Chr2:77534306-77569799 (-)
C57BL/6NJ ENSMUSG00215018896
 protein coding gene Chr2:77363840-77399502 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023706
 protein coding gene Chr2:75087797-75121293 (-)
CAST/EiJ ENSTCUG00005027107
 protein coding gene Chr2:76868684-76904175 (-)
CBA/J ENSMUSG00210002378
 protein coding gene Chr2:77566619-77602114 (-)
DBA/2J ENSMUSG00185010716
 protein coding gene Chr2:77402963-77438454 (-)
FVB/NJ ENSMUSG00205011095
 protein coding gene Chr2:76750867-76786378 (-)
JF1/MsJ ENSUMUG00000020837
 protein coding gene Chr2:77117611-77152779 (-)
LP/J ENSMUSG00230024664
 protein coding gene Chr2:79208609-79244110 (-)
NOD/ShiLtJ ENSMUSG00190009948
 protein coding gene Chr2:77479608-77515134 (-)
NZO/HlLtJ ENSMUSG00225001592
 protein coding gene Chr2:86955326-86990988 (-)
PWK/PhJ ENSLUMG00010029898
 protein coding gene Chr2:77275994-77311205 (-)
SPRET/EiJ ENSMSPG00010021014
 protein coding gene Chr2:78637010-78671918 (-)
WSB/EiJ ENSIUOG00005010958
 protein coding gene Chr2:78436496-78472017 (+)



Homology
more
  • Human Ortholog
    FRZB, frizzled related protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRZB, frizzled related protein
  • Synonyms
    FRE, FRITZ, FRP-3, FRZB-1, FRZB1, FRZB-PEN, FZRB, hFIZ, OS1, SFRP3, SRFP3
  • Links
    NCBI Gene ID: 2487
    UniProt: Q92765

  • Chr Location
    2q32.1; chr2:182833275-182866638 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FRZB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display defects in motor coordination and capability and a decrease in thermal pain sensation. Mice homozygous for another null allele display enhanced reactive bone formation and cortical bone abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1576
  • Tissues
    481
  • cDNA Data
    48
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20378 NCBI Gene Model | MGI Sequence Detail 35427 C57BL/6J ±  kb
    transcript NM_011356 RefSeq | MGI Sequence Detail 2920 ZRU/MplStud  
    polypeptide P97401 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 4
      cDNA 50
      Primer pair 18
      Other 8
      Antibodies 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 66
      Gene Ontology 17
      Phenotypes 25
    • Earliest
      J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
    • Latest
      J:377967 Roome RB, et al., Ontogeny of the spinal cord dorsal horn. Science. 2026 Jan 8;391(6781):eadx5781
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory