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Gene Expression Data
Assay Details
Assay
Reference: J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8270447
Gene symbol: Slc6a3
Gene name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Antibody: anti-dopamine transporter (MAB369)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: Nolz1-/- mutant embryos, in which the coding region of Nolz1 has been replaced by beta-Galactosidase (also referred to as Nolz1<bgal/bgal>). Zfp503<tm1.1Bpb> (neo cassette removed) has been used in the annotations, but it could be Zfp503<tm1Bpb> (neo cassette still present).
Results
Specimen 1e: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted 1e Expression was detected in dopaminergic axons.
Specimen 1f: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted 1f A subset of immunolabeled dopaminergic axons cross the midline.
Specimen 1g: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 1g Expression was detected in dopaminergic axons.
Specimen 1h: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: corpus striatum Ambiguous Regionally restricted 1h The rostral striatum lacks dopaminergic axon innervation in the mutant.
Specimen 1i: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 1i Expression was detected in dopaminergic axons.
TS26: globus pallidus Present Regionally restricted 1i Expression was detected in dopaminergic axons.
Specimen 1j: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: brain Present Regionally restricted 1j Immunolabeled dopaminergic axons terminate rostral of the striatum.
TS26: globus pallidus Absent 1j The globus pallidus lacks innervation by dopaminergic axons.
Specimen 1k: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Th (assay MGI:8270443).
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted 1k Expression was detected in dopaminergic axons.
Specimen 1l: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Th (assay MGI:8270443).
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted 1l Mainly Slc6a3-positive;TH-positive substantia nigra dopaminergic axon bundles cross the midline.
Specimen 1m: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Th (assay MGI:8270443).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 1m Expression was detected in dopaminergic axons.
Specimen 1n: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Th (assay MGI:8270443).
Structure Level Pattern Image Note
TS26: brain Ambiguous 1n Slc6a3-negative;TH-positive dopaminergic axons extend towards the striatum. The rostral striatum lacks Slc6a3-positive dopaminergic innervation.
Specimen 1o: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Th (assay MGI:8270443).
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 1o Expression was detected in dopaminergic axons.
TS26: diencephalon Present Regionally restricted 1o Expression was detected in dopaminergic axons in caudal diencephalon.
Specimen 1p: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Th (assay MGI:8270443).
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted 1p The dopaminergic axon bundle is defasciculated and more spread out along the medial-lateral axis in Nolz1-/- mutant embryos.
TS26: midbrain Present Regionally restricted 1p The dopaminergic axon bundle is defasciculated and more spread out along the medial-lateral axis in Nolz1-/- mutant embryos.
Specimen 1q: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503+ (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 reporter (assay MGI:8270491).
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted 1q Expression was detected in dopaminergic axons.
Specimen 1r: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 reporter (assay MGI:8270491).
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted 1r A subset of immunolabeled dopaminergic axons cross the midline.
Specimen 1s: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503+ (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 reporter (assay MGI:8270491).
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted 1s Expression was detected in dopaminergic axons.
Specimen 1t: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 reporter (assay MGI:8270491).
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted 1t Expression was detected in dopaminergic axons, which displayed an axon guidance phenotype.
Specimen 1u: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503+ (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 reporter (assay MGI:8270491).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 1u Expression was detected in dopaminergic axons.
Specimen 1v: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 reporter (assay MGI:8270491).
Structure Level Pattern Image Note
TS26: brain Present Regionally restricted 1v Immunolabeled dopaminergic axons terminate rostral of the striatum.
Specimen 1w: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503+ (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 reporter (assay MGI:8270491).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 1w Expression was detected in dopaminergic axons.
Specimen 1x: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 reporter (assay MGI:8270491).
Structure Level Pattern Image Note
TS26: globus pallidus Absent 1x The globus pallidus lacks innervation by dopaminergic axons.
Specimen 2o: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Ppp1r1b (assay MGI:8270622).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 2o Expression was detected in dopaminergic terminals.
Specimen 2p: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Ppp1r1b (assay MGI:8270622).
Structure Level Pattern Image Note
TS26: corpus striatum Weak Regionally restricted 2p Expression was reduced in dopaminergic terminals.
Specimen 2q: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Ppp1r1b (assay MGI:8270622).
Structure Cell Type Level Pattern Image Note
TS26: midbrain midbrain dopaminergic neuron Present 2q
Specimen 2r: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Ppp1r1b (assay MGI:8270622).
Structure Cell Type Level Pattern Image Note
TS26: midbrain midbrain dopaminergic neuron Present 2r
Specimen 2s: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Ppp1r1b (assay MGI:8270622).
Structure Cell Type Level Pattern Image Note
TS26: midbrain midbrain dopaminergic neuron Present 2s
Specimen 2t: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Ppp1r1b (assay MGI:8270622).
Structure Cell Type Level Pattern Image Note
TS26: midbrain midbrain dopaminergic neuron Present 2t
Specimen 5b: embryonic day 18.5 (more )
Note: Controls were either: Cre+, Cre+;Nolz1fl/+, or Nolz1fl/fl. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 5b Expression was detected in dopaminergic axons.
Specimen 5c: embryonic day 18.5; Foxg1tm1.1(cre)Ddmo/Foxg1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: corpus striatum Weak 5c Selective ablation of Zfp503 (Nolz1) in the striatum of FoxG1-IRES-Cre;Nolz1<fl/fl> resulted in a dopaminergic axon defect highly similar to the phenotype observed in the Nolz1-/- mutant embryos. There was a strong reduction in striatal innervation by dopaminergic terminals.
Specimen 5d: embryonic day 18.5; Foxd1tm1(GFP/cre)Amc/Foxd1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 5d No changes in dopaminergic axons striatal innervation were observed in the Foxd1-Cre;Nolz1<fl/fl> embryos.
Specimen 5e: embryonic day 18.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 5e No changes in dopaminergic axons striatal innervation were observed En1Cre;Nolz1<fl/fl> embryos.
Specimen 5b': embryonic day 18.5 (more )
Note: Controls were either: Cre+, Cre+;Nolz1fl/+, or Nolz1fl/fl. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted 5b' Expression was detected in dopaminergic axons.
Specimen 5c': embryonic day 18.5; Foxg1tm1.1(cre)Ddmo/Foxg1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: hypothalamus Weak 5c' Selective ablation of Zfp503 (Nolz1) in the striatum of FoxG1-IRES-Cre;Nolz1fl/fl resulted in a dopaminergic axon defect highly similar to the phenotype observed in the Nolz1-/- mutant embryos. A subset of dopaminergic axon bundles crossed the midline, although to a lesser extent than in the Nolz1-/- embryos.
Specimen 5d': embryonic day 18.5; Foxd1tm1(GFP/cre)Amc/Foxd1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted 5d' No changes in dopaminergic axons guidance were observed Foxd1-Cre;Nolz1<fl/fl> embryos.
Specimen 5e': embryonic day 18.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted 5e' No changes in dopaminergic axons guidance were observed En1Cre;Nolz1<fl/fl> embryos.
Specimen 5b'': embryonic day 18.5 (more )
Note: Controls were either: Cre+, Cre+;Nolz1fl/+, or Nolz1fl/fl. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 5b'' Expression was detected in dopaminergic axons.
Specimen 5c'': embryonic day 18.5; Foxg1tm1.1(cre)Ddmo/Foxg1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: midbrain Present 5c''
Specimen 5d'': embryonic day 18.5; Foxd1tm1(GFP/cre)Amc/Foxd1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 5d'' No changes in dopaminergic axons guidance were observed Foxd1-Cre;Nolz1<fl/fl> embryos.
Specimen 5e'': embryonic day 18.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: midbrain Present Regionally restricted 5e'' No changes in dopaminergic axons guidance were observed En1Cre;Nolz1<fl/fl> embryos.
Specimen 5j: embryonic day 18.5 (more )
Note: Controls were either: Cre+, Cre+;Nolz1fl/+, or Nolz1fl/fl. Double labeled: green - Slc6a3; red - Ppp1r1b (assay MGI:8270622).
Structure Level Pattern Image Note
TS26: corpus striatum Present Regionally restricted 5j Expression was detected in dopaminergic axons.
Specimen 5k: embryonic day 18.5; Foxg1tm1.1(cre)Ddmo/Foxg1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Ppp1r1b (assay MGI:8270622).
Structure Level Pattern Image Note
TS26: corpus striatum Weak Regionally restricted 5k Striatal innervation by dopaminergic terminals was reduced in the FoxG1-IRES-Cre;Nolz<fl/fl>.
Specimen S1b WT merge left: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - 5HT.
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted S1b WT merge left Expression was detected in dopaminergic axons.
Specimen S1b Nolz1-/- merge left: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - 5HT.
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted S1b Nolz1-/- merge left A subset of immunolabeled dopaminergic axons cross the midline.
Specimen S1b WT merge right: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - 5HT.
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted S1b WT merge right Expression was detected in dopaminergic axons.
Specimen S1b Nolz1-/- merge right: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - 5HT.
Structure Level Pattern Image Note
TS26: hypothalamus Present Regionally restricted S1b Nolz1-/- merge right A subset of immunolabeled dopaminergic axons cross the midline.
Specimen S1c WT: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Th (assay MGI:8270443).
Structure Cell Type Level Pattern Image Note
TS26: midbrain midbrain dopaminergic neuron Present S1c WT GlycoDAT TH
Specimen S1c Nolz1bGal/bGal: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Th (assay MGI:8270443).
Structure Cell Type Level Pattern Image Note
TS26: midbrain midbrain dopaminergic neuron Present S1c Nolz1bgal/bgal GlycoDAT TH
Specimen S2a WT: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Nkx2-1 (assay MGI:8272302).
Structure Level Pattern Image Note
TS26: globus pallidus Present S2a WT top , S2a WT bottom
Specimen S2a Nolz1-/-: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: green - Slc6a3; red - Nkx2-1 (assay MGI:8272302).
Structure Level Pattern Image Note
TS26: globus pallidus Absent S2a Nolz1-/- top , S2a Nolz1-/- bottom
Specimen S2a Foxg1IresCre;Nolz1fl/fl: embryonic day 18.5; Foxg1tm1.1(cre)Ddmo/Foxg1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Nkx2-1 (assay MGI:8272302).
Structure Level Pattern Image Note
TS26: globus pallidus Absent S2a Foxg1-IresCre;Nolz1fl/fl bottom , S2a Foxg1-IresCre;Nolz1fl/fl top
Specimen S5d: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: brain Present Regionally restricted S5d' , S5d Labeling of the innervation of the prefrontal cortex.
Specimen S5e: embryonic day 18.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: brain Present Regionally restricted S5e' , S5e Innervation of the prefrontal cortex was normally initiated in EnCre;Nolz1<fl/fl> mutant embryos.
Specimen S5g WT top: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g WT top Expression was detected in dopaminergic axons.
Specimen S5g FoxD1Cre;Nolz1fl/fl top: embryonic day 18.5; Foxd1tm1(GFP/cre)Amc/Foxd1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g FoxD1Cre;Nolz1fl/fl top The conditional deletion in the hypothalamus did not affect the guidance of dopaminergic axons projections in the diencephalon.
Specimen S5g En1Cre;Nolz1fl/fl top: embryonic day 18.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g En1Cre;Nolz1fl/fl top The conditional deletion in the midbrain did not affect the guidance of dopaminergic axons projections in the diencephalon.
Specimen S5g WT middle: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g WT middle Expression was detected in dopaminergic axons.
Specimen S5g FoxD1Cre;Nolz1fl/fl middle: embryonic day 18.5; Foxd1tm1(GFP/cre)Amc/Foxd1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g FoxD1Cre;Nolz1fl/fl middle The conditional deletion in the hypothalamus did not affect the guidance of dopaminergic axons projections in the diencephalon.
Specimen S5g En1Cre;Nolz1fl/fl middle: embryonic day 18.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g En1Cre;Nolz1fl/fl middle The conditional deletion in the midbrain did not affect the guidance of dopaminergic axons projections in the diencephalon.
Specimen S5g WT bottom: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g WT bottom Expression was detected in dopaminergic axons.
Specimen S5g FoxD1Cre;Nolz1fl/fl bottom: embryonic day 18.5; Foxd1tm1(GFP/cre)Amc/Foxd1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g FoxD1Cre;Nolz1fl/fl bottom The conditional deletion in the hypothalamus did not affect the guidance of dopaminergic axons projections in the diencephalon.
Specimen S5g En1Cre;Nolz1fl/fl bottom: embryonic day 18.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: diencephalon Present Regionally restricted S5g En1Cre;Nolz1fl/fl bottom The conditional deletion in the midbrain did not affect the guidance of dopaminergic axons projections in the diencephalon.
Specimen S5h WT: embryonic day 18.5 (more )
Note: Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: brain Present Regionally restricted S5h WT Expression was detected in dopaminergic axons.
Specimen S5h En1Cre;Nolz1fl/fl: embryonic day 18.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant. Double labeled: green - Slc6a3; red - Zfp503 (assay MGI:8270488).
Structure Level Pattern Image Note
TS26: brain Present Regionally restricted S5h En1Cre;Nolz1fl/fl There was no difference in dopaminergic axons projections in the En1Cre;Nolz1<fl/fl> mutant brain.
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