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Gene Expression Data
Assay Details
Assay
Reference: J:178497 Huettl RE, et al., Cranial nerve fasciculation and Schwann cell migration are impaired after loss of Npn-1. Dev Biol. 2011 Nov 15;359(2):230-41
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7514336
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Antibody: anti-Sox10
Results
Specimen 5B: embryonic day 11.5 (more )
Note: Control littermates were Npn-1cond+/+;Cre+ or Npn-1cond-/-;Cre-. Double labeled: red - Sox10; green - Nefm (assay MGI:7514320).
Structure Cell Type Level Pattern Image Note
TS20: hypoglossal nerve Schwann cell precursor Present 5B Immunopositive Schwann cell precursors migrate along the entire length of the hypoglossal nerve.
Specimen 5C: embryonic day 11.5; Nrp1tm2Ddg/Nrp1tm2Ddg, Tg(PLAT-cre)116Sdu/0 (more )
Note: Conditional mutant. Double labeled: red - Sox10; green - Nefm (assay MGI:7514320).
Structure Cell Type Level Pattern Image Note
TS20: hypoglossal nerve Schwann cell precursor Present Regionally restricted 5C Some rootlets of the hypoglossal nerve are devoid of immunopositive Schwann cells.
Specimen 5D: embryonic day 11.5; Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet, Tg(PLAT-cre)116Sdu/0 (more )
Note: Conditional mutant. Double labeled: red - Sox10; green - Nefm (assay MGI:7514320).
Structure Level Pattern Image Note
TS20: hypoglossal nerve Absent 5D In the mutant, the hypoglossal nerve lacks Schwann cells.
Specimen 5E: embryonic day 11.5 (more )
Note: Control littermates were Npn-1cond+/+;Cre+ or Npn-1cond-/-;Cre-. Double labeled: red - Sox10; green - Nefm (assay MGI:7514320).
Structure Cell Type Level Pattern Image Note
TS20: hypoglossal nerve Schwann cell precursor Present Regionally restricted 5E At the tip of the hypoglossal nerve, the immunopositive Schwann cell precursors lag behind the leading axons.
Specimen 5F: embryonic day 11.5; Nrp1tm2Ddg/Nrp1tm2Ddg, Tg(PLAT-cre)116Sdu/0 (more )
Note: Conditional mutant. Double labeled: red - Sox10; green - Nefm (assay MGI:7514320).
Structure Cell Type Level Pattern Image Note
TS20: hypoglossal nerve Schwann cell precursor Present Regionally restricted 5F In mutant embryos, migration of immunopositive Schwann cells along the axons to the tip of the hypoglossal nerve is not impaired.
Specimen 5G: embryonic day 11.5; Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet, Tg(PLAT-cre)116Sdu/0 (more )
Note: Conditional mutant. Double labeled: red - Sox10; green - Nefm (assay MGI:7514320).
Structure Level Pattern Image Note
TS20: hypoglossal nerve Absent 5G In the mutant, the hypoglossal nerve lacks Schwann cells at the tip.
Specimen S2F: embryonic day 11.5 (more )
Note: Control littermates were Npn-1cond+/+;Cre+ or Npn-1cond-/-;Cre-. Double labeled: red - Sox10; green - Nefm (assay MGI:7514320).
Structure Cell Type Level Pattern Image Note
TS20: hypoglossal nerve Schwann cell precursor Present S2F
Specimen S2G: embryonic day 11.5; Nrp1tm1Ddg/Nrp1tm1Ddg (more )
Note: Double labeled: red - Sox10; green - Nefm (assay MGI:7514320).
Structure Cell Type Level Pattern Image Note
TS20: hypoglossal nerve Schwann cell precursor Present Regionally restricted S2G A reduction of immunopositive-Schwann cells migrating along the defaciculated hypoglossal rootlets was observed in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
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