About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:127471 Wang S, et al., Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6449800
Gene symbol: Myt1
Gene name: myelin transcription factor 1
Antibody: anti-Myt1
Detection system: Cy3
Results
Specimen 1A1 inset: embryonic day 8.5 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS13: foregut-midgut junction Ambiguous Regionally restricted 1A1 inset No expression in prospective pancreatic epithelium before E8.5.
Specimen 1A1: embryonic day 9.0 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS14: foregut-midgut junction Present Regionally restricted 1A1 Most expressing cells in prospective pancreas also express Pdx1.
Specimen 1A2: embryonic day 10.5 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 1A2 Expression in all insulin-expressing cells.
Specimen 1A3: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted 1A3 Expression maintained in 91% of insulin-expressing cells.
Specimen 1A4: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1A4 Expression detected in 58.6% of insulin-expressing cells.
Specimen 1B1: embryonic day 9.0 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS14: foregut-midgut junction Present Regionally restricted 1B1 Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1B2: embryonic day 10.5 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 1B2 Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1B3: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted 1B3 Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1B4: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1B4 Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1B4 inset: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1B4 inset Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1C1: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Ppy (assay MGI:6449810).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted 1C1 Expression in Sst-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied.
Specimen 1C2: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Ppy (assay MGI:6449810).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1C2 Expression in Sst-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied.
Specimen 1C2 inset: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Ppy (assay MGI:6449810).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 1C2 inset
Specimen 1D1: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Sst (assay MGI:6449811).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted 1D1 Expression in Ppy-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied.
Specimen 1D2: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Sst (assay MGI:6449811).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1D2 Expression in Ppy-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied.
Specimen 1D2 inset: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Sst (assay MGI:6449811).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 1D2 inset
Specimen 2 E10.5: embryonic day 10.5 (more )
Note: Double labeled: red - Myt1; green - Neurog3 (assay MGI:6449812).
Structure Level Pattern Image Note
TS17: pancreas primordium Present 2_E10.5 Merge , 2_E10.5 Myt1
Specimen 2 E13.5: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Neurog3 (assay MGI:6449812).
Structure Level Pattern Image Note
TS21: pancreas Present 2_E13.5 Myt1 , 2_E13.5 Merge
Specimen 2 E15.5: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Neurog3 (assay MGI:6449812).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present 2_E15.5 Merge , 2_E15.5 Myt1
Specimen S1 E13.5 Isl1: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Isl1 (assay MGI:6449817).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 Isl1 (bottom) , S1_E13.5 Isl1 (merge) Expression overlaps with expression of Isl1.
Specimen S1 E13.5 MafA: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Mafa (assay MGI:6449813).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 MafA (bottom) , S1_E13.5 MafA (merge) Expression overlaps with expression of Mafa.
Specimen S1 E13.5 MafB: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Mafb (assay MGI:6449814).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 MafB (merge) , S1_E13.5 MafB (bottom) Expression overlaps with expression of Mafb.
Specimen S1 E13.5 Nkx6.1: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Nkx6-1 (assay MGI:6449819).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 Nkx6.1 (bottom) , S1_E13.5 Nkx6.1 (merge) Expression overlaps with expression of Nkx6.1.
Specimen S1 E15.5 Isl1: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Isl1 (assay MGI:6449817).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S1_E15.5 Isl1 (merge) , S1_E15.5 Isl1 (bottom)
Specimen S1 E15.5 MafA: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Mafa (assay MGI:6449813).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S1_E15.5 MafA (merge) , S1_E15.5 MafA (bottom)
Specimen S1 E15.5 MafB: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Mafb (assay MGI:6449814).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S1_E15.5 MafB (merge) , S1_E15.5 MafB (bottom)
Specimen S1 E15.5 Nkx6.1: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Nkx6-1 (assay MGI:6449819).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S1_E15.5 Nkx6.1 (bottom) , S1_E15.5 Nkx6.1 (merge)
Specimen S5A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S5A
Specimen S5B: embryonic day 15.5; Myt1tm1.1Ggu/Myt1tm1.1Ggu (more )
Structure Level Pattern Image Note
TS23: islets of Langerhans Absent S5B
Specimen S5C: embryonic day 15.5; Myt1tm1Ggu/Myt1tm1.1Ggu, Tg(Pdx1-cre)89.1Dam/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: islets of Langerhans Weak S5C Expression reduced compared to wild type.
Specimen S5D: embryonic day 18.5; Myt1tm1Ggu/Myt1tm1.1Ggu, Tg(Pdx1-cre)89.1Dam/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: islets of Langerhans Absent S5D No expression in pancreatic cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory