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Gene Expression Data
Assay Details
Assay
Reference: J:127471 Wang S, et al., Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6449813
Gene symbol: Mafa
Gene name: MAF bZIP transcription factor A
Antibody: anti-MafA
Detection system: fluorescein
Results
Specimen wild type not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted Expression in most wild-type beta cells.
Specimen 6A: postnatal adult; Myt1tm1Ggu/Myt1tm1.1Ggu, Tg(Pdx1-cre)89.1Dam/? (more )
Note: Conditional mutant. Triple labeled: blue - Mafa; green - Gcg (assay MGI:6449809); red - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 6A MafA , 6A merge No expression in glucagon+ insulin+ cells.
Specimen 6B: postnatal adult; Myt1tm1Ggu/Myt1tm1.1Ggu, Tg(Pdx1-cre)89.1Dam/? (more )
Note: Conditional mutant. Triple labeled: blue - Mafa; green - Ppy (assay MGI:6449810); red - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 6B merge , 6B MafA No expression in insulin+ Ppy+ cells.
Specimen S1 E13.5 MafA: embryonic day 13.5 (more )
Note: Double labeled: green - Mafa; red - Myt1 (assay MGI:6449800).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 MafA (top) , S1_E13.5 MafA (merge) Expression overlaps with that of Myt1.
Specimen S1 E15.5 MafA: embryonic day 15.5 (more )
Note: Double labeled: green - Mafa; red - Myt1 (assay MGI:6449800).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted S1_E15.5 MafA (top) , S1_E15.5 MafA (merge) Expression overlaps with that of Myt1.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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