Myt1 MGI Mouse Gene Detail - MGI:1100535 - myelin transcription factor 1

Symbol

Myt1
Name

myelin transcription factor 1
Synonyms

mKIAA0835, Nzf2, NZF-2a, NZF-2b, Nztf2

Feature Type

protein coding gene
IDs

MGI:1100535
NCBI Gene: 17932
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:181405125-181469590 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 103.77 cM
Mapping Data

5 experiments

SNPs within 2kb

982 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100535	protein coding gene	Chr2:181405099-181469590 (+)
129S1/SvImJ	ENSMUSG00200002185	protein coding gene	Chr2:177427919-177492653 (+)
A/J	ENSMUSG00195001032	protein coding gene	Chr2:177651855-177716626 (+)
AKR/J	ENSMUSG00220000079	protein coding gene	Chr2:175330516-175395290 (+)
BALB/cJ	ENSMUSG00180000686	protein coding gene	Chr2:175468862-175533343 (+)
C3H/HeJ	ENSMUSG00175004304	protein coding gene	Chr2:176612404-176677164 (+)
C57BL/6NJ	ENSMUSG00215002539	protein coding gene	Chr2:175567226-175631699 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024821	protein coding gene	Chr2:171296236-171361954 (+)
CAST/EiJ	ENSTCUG00005000547	protein coding gene	Chr2:174910947-174975268 (+)
CBA/J	ENSMUSG00210001437	protein coding gene	Chr2:175945703-176010419 (+)
DBA/2J	ENSMUSG00185020728	protein coding gene	Chr2:177171859-177236633 (+)
FVB/NJ	ENSMUSG00205002062	protein coding gene	Chr2:175997325-176061807 (+)
JF1/MsJ	ENSUMUG00000012771	protein coding gene	Chr2:178375782-178440179 (+)
LP/J	ENSMUSG00230024087	protein coding gene	Chr2:179078824-179143564 (+)
NOD/ShiLtJ	ENSMUSG00190015209	protein coding gene	Chr2:175487337-175552061 (+)
NZO/HlLtJ	ENSMUSG00225006052	protein coding gene	Chr2:187160867-187225347 (+)
PWK/PhJ	ENSLUMG00010000127	protein coding gene	Chr2:175785942-175850435 (+)
SPRET/EiJ	ENSMSPG00010003799	protein coding gene	Chr2:178259354-178324219 (+)
WSB/EiJ	ENSIUOG00005000176	protein coding gene	Chr2:175505317-175569761 (+)

Human Ortholog

MYT1, myelin transcription factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYT1, myelin transcription factor 1
Synonyms

C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2H2C1, ZC2HC4A
Links

HGNC:7622

NCBI Gene ID: 4661

UniProt: Q01538
Chr Location

20q13.33; chr20:64102222-64242253 (+) GRCh38

MGI Vertebrate Homology

Myt1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYT1
Gene Tree

Myt1

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Phenotype Summary

11 phenotypes from 4 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Targeted

5
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele die shortly after birth displaying improper diaphragm innervation and a failture to initiate breathing; mutant embryonic pancreata contain abnormal islet cells that express multiple hormones.

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

958
Tissues

171
cDNA Data

17
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MYT1

Xenbase myt1

ZFIN myt1a, myt1b

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All Sequences

95
RefSeq

37
UniProt

7
CCDS

CCDS17223.1, CCDS50856.1, CCDS50857.1

Ensembl

ENSMUSG00000010505 (Evidence)
NCBI Gene

17932

			Length	Strain/Species	Flank
genomic	ENSMUSG00000010505	Ensembl Gene Model \| MGI Sequence Detail	64466	C57BL/6J	± kb
transcript	ENSMUST00000081125	Ensembl \| MGI Sequence Detail	5327	Not Applicable
polypeptide	ENSMUSP00000079900	Ensembl \| MGI Sequence Detail	1169	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010892 myelin transcription factor 1

(term hierarchy)
PDB

2JX1, 2JYD, 2MF8
InterPro Domains

IPR013681 Myelin transcription factor 1

IPR002515 Zinc finger, C2H2C-type

IPR036060 Zinc finger, C2H2C-type superfamily
GlyGen

Q8CFC2 7 sites, 1 N-linked glycan (1 site)

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All nucleic 26

cDNA 18

Primer pair 8

Antibodies 4

Microarray probesets 4

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MGD-MRK-38473, MGI:109428

Summaries

All 74

Developmental Gene Expression 36

Gene Ontology 9

Phenotypes 12
Earliest

J:39021 Jiang Y, et al., A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996 May 3;271(18):10723-30
Latest

J:370197 Brown ME, et al., Pancreatic islet beta-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors. Nat Commun. 2025 Jul 1;16(1):5758

TSS for Myt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22342	Chr2:181405108-181405128 (+)	-7 bp
Tssr22343	Chr2:181408798-181408830 (+)	3,689 bp
Tssr22344	Chr2:181408833-181408866 (+)	3,725 bp
Tssr22345	Chr2:181408910-181408922 (+)	3,791 bp
Tssr22346	Chr2:181409076-181409114 (+)	3,970 bp
Tssr22347	Chr2:181409136-181409178 (+)	4,032 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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