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Gene Expression Data
Assay Details
Assay
Reference: J:132598 Nishimura W, et al., Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15;314(2):443-56
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6382879
Gene symbol: Ins2
Gene name: insulin II
Antibody: anti-insulin
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to Texas Red
Results
Specimen S1A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pax6 (assay MGI:6382870).
Structure Level Pattern Image Note
TS23: pancreas Present S1A
Specimen S1B: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Gluc (Gcg assay MGI:6382867).
Structure Level Pattern Image Note
TS23: pancreas Present S1B
Specimen S1C: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx2-2 (assay MGI:6382869).
Structure Level Pattern Image Note
TS23: pancreas Present S1C
Specimen S1D: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx6-1 (assay MGI:6382861).
Structure Level Pattern Image Note
TS23: pancreas Present S1D
Specimen S1E: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Neurog3 (assay MGI:6382868).
Structure Level Pattern Image Note
TS23: pancreas Present S1E
Specimen S1F: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pax6 (assay MGI:6382870).
Structure Level Pattern Image Note
TS23: pancreas Weak S1F Expression signficantly reduced compared with wild type.
Specimen S1G: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Gluc (Gcg assay MGI:6382867).
Structure Level Pattern Image Note
TS23: pancreas Weak S1G Expression signficantly reduced compared with wild type.
Specimen S1H: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx2-2 (assay MGI:6382869).
Structure Level Pattern Image Note
TS23: pancreas Weak S1H Expression signficantly reduced compared with wild type.
Specimen S1I: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx6-1 (assay MGI:6382861).
Structure Level Pattern Image Note
TS23: pancreas Weak S1I Expression signficantly reduced compared with wild type.
Specimen S1J: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Neurog3 (assay MGI:6382868).
Structure Level Pattern Image Note
TS23: pancreas Weak S1J Expression signficantly reduced compared with wild type.
Specimen 1A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx6-1 (assay MGI:6382861).
Structure Level Pattern Image Note
TS23: pancreas Present 1A
Specimen 1B: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafb (assay MGI:6382862).
Structure Level Pattern Image Note
TS23: pancreas Present 1B
Specimen 1C: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pdx1 (assay MGI:6382863).
Structure Level Pattern Image Note
TS23: pancreas Present 1C
Specimen 1D: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafa (assay MGI:6382864).
Structure Level Pattern Image Note
TS23: pancreas Present 1D
Specimen 1E: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx6-1 (assay MGI:6382861).
Structure Level Pattern Image Note
TS23: pancreas Weak 1E Reduction in number of expressing cells.
Specimen 1F: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafb (assay MGI:6382862).
Structure Level Pattern Image Note
TS23: pancreas Weak 1F Reduction in number of expressing cells.
Specimen 1G: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pdx1 (assay MGI:6382863).
Structure Level Pattern Image Note
TS23: pancreas Weak 1G
Specimen 1H: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafa (assay MGI:6382864).
Structure Level Pattern Image Note
TS23: pancreas Weak 1H
Specimen 1I: embryonic day 17.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx6-1 (assay MGI:6382861).
Structure Level Pattern Image Note
TS25: pancreas Present 1I
Specimen 1J: embryonic day 17.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafb (assay MGI:6382862).
Structure Level Pattern Image Note
TS25: pancreas Present 1J
Specimen 1K: embryonic day 17.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pdx1 (assay MGI:6382863).
Structure Level Pattern Image Note
TS25: pancreas Present 1K
Specimen 1L: embryonic day 17.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafa (assay MGI:6382864).
Structure Level Pattern Image Note
TS25: pancreas Present 1L
Specimen 1M: embryonic day 17.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx6-1 (assay MGI:6382861).
Structure Level Pattern Image Note
TS25: pancreas Trace 1M Greater reduction in number of expressing cells at E17.5 than at E15.5.
Specimen 1N: embryonic day 17.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafb (assay MGI:6382862).
Structure Level Pattern Image Note
TS25: pancreas Trace 1N Greater reduction in number of expressing cells at E17.5 than at E15.5.
Specimen 1O: embryonic day 17.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pdx1 (assay MGI:6382863).
Structure Level Pattern Image Note
TS25: pancreas Trace 1O Greater reduction in number of expressing cells at E17.5 than at E15.5.
Specimen 1P: embryonic day 17.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafa (assay MGI:6382864).
Structure Level Pattern Image Note
TS25: pancreas Trace 1P
Specimen S2A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2 and Gcg (assay MGI:6382866); green - Ghrl (assay MGI:6382871).
Structure Level Pattern Image Note
TS23: pancreas Present S2A
Specimen S2B: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2 and Gcg (assay MGI:6382866); green - Ghrl (assay MGI:6382871).
Structure Level Pattern Image Note
TS23: pancreas Weak S2B Reduction in number of expressing cells compared to wild type.
Specimen S3A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Hb9 (Mnx1 assay MGI:6382874).
Structure Level Pattern Image Note
TS23: pancreas Present S3A
Specimen S3B: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: red - Ins1 and Ins2; green - Hb9 (Mnx1 assay MGI:6382874).
Structure Level Pattern Image Note
TS23: pancreas Weak S3B Reduction in number of expressing cells compared to wild type.
Specimen 5A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Gluc (Gcg assay MGI:6382867).
Structure Level Pattern Image Note
TS23: pancreas Present 5A
Specimen 5B: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: red - Ins1 and Ins2; green - Gluc (Gcg assay MGI:6382867).
Structure Level Pattern Image Note
TS23: pancreas Trace 5B Drastic reduction in number of expressing cels compared with wild type.
Specimen 6A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Neurog3 (assay MGI:6382868).
Structure Level Pattern Image Note
TS23: pancreas Present 6A
Specimen 6B: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx2-2 (assay MGI:6382869).
Structure Level Pattern Image Note
TS23: pancreas Present 6B
Specimen 6C: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pax6 (assay MGI:6382870).
Structure Level Pattern Image Note
TS23: pancreas Present 6C
Specimen 6D: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: red - Ins1 and Ins2; green - Neurog3 (assay MGI:6382868).
Structure Level Pattern Image Note
TS23: pancreas Weak 6D Expression reduced compared with wild type.
Specimen 6E: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx2-2 (assay MGI:6382869).
Structure Level Pattern Image Note
TS23: pancreas Weak 6E Expression reduced compared with wild type.
Specimen 6F: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pax6 (assay MGI:6382870).
Structure Level Pattern Image Note
TS23: pancreas Weak 6F
Specimen 7A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafb (assay MGI:6382862).
Structure Level Pattern Image Note
TS23: pancreas Present 7A
Specimen 7B: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2;green - Nkx6-1 (assay MGI:6382861).
Structure Level Pattern Image Note
TS23: pancreas Present 7B
Specimen 7C: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pdx1 (assay MGI:6382863).
Structure Level Pattern Image Note
TS23: pancreas Present 7C
Specimen 7D: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafa (assay MGI:6382864).
Structure Level Pattern Image Note
TS23: pancreas Present 7D
Specimen 7E: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafb (assay MGI:6382862).
Structure Level Pattern Image Note
TS23: pancreas Weak 7E Number of expressing cells reduced compared with wild type.
Specimen 7F: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Nkx6-1 (assay MGI:6382861).
Structure Level Pattern Image Note
TS23: pancreas Weak 7F Number of expressing cells reduced compared with wild type.
Specimen 7G: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Pdx1 (assay MGI:6382863).
Structure Level Pattern Image Note
TS23: pancreas Weak 7G Number of expressing cells reduced compared with wild type.
Specimen 7H: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Mafa (assay MGI:6382864).
Structure Level Pattern Image Note
TS23: pancreas Weak 7H
Specimen 8A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2 and Gcg (assay MGI:6382866); green - Sst (assay MGI:6382871).
Structure Level Pattern Image Note
TS23: pancreas Present 8A
Specimen 8B: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2 and Gcg (assay MGI:6382866); green - Ghrl (assay MGI:6382871).
Structure Level Pattern Image Note
TS23: pancreas Present 8B
Specimen 8C: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: red - Ins1 and Ins2 and Gcg (assay MGI:6382866); green - Sst (assay MGI:6382871).
Structure Level Pattern Image Note
TS23: pancreas Weak 8C Reduction in number of expressing cells compared to wild type.
Specimen 8D: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: red - Ins1 and Ins2 and Gcg (assay MGI:6382866); green - Ghrl (assay MGI:6382871).
Structure Level Pattern Image Note
TS23: pancreas Weak 8D Reduction in number of expressing cells compared to wild type.
Specimen 9A: embryonic day 15.5 (more )
Note: Double labeled: red - Ins1 and Ins2; green - Hb9 (Mnx1 assay MGI:6382874).
Structure Level Pattern Image Note
TS23: pancreas Present 9A
Specimen 9B: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: red - Ins1 and Ins2; green - Hb9 (Mnx1 assay MGI:6382874).
Structure Level Pattern Image Note
TS23: pancreas Weak 9B Reduction in number of expressing cells compared to wild type.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory