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Gene Expression Data
Assay Details
Assay
Reference: J:132598 Nishimura W, et al., Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15;314(2):443-56
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6382863
Gene symbol: Pdx1
Gene name: pancreatic and duodenal homeobox 1
Antibody: anti-PDX-1
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to Alexa Fluor 488
Results
Specimen 1C: embryonic day 15.5 (more )
Note: Double labeled: green - Pdx1; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS23: pancreas Present 1C
Specimen 1G: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: green - Pdx1; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS23: pancreas Weak 1G Induced expression significantly reduced compared with wild type.
Specimen 1K: embryonic day 17.5 (more )
Note: Double labeled: green - Pdx1; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS25: pancreas Present 1K
Specimen 1O: embryonic day 17.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: green - Pdx1; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS25: pancreas Weak Regionally restricted 1O Number of expressing cells reduced compared with wild type. Majority of induced expression restricted to insulin-expressing cells.
Specimen 3B: embryonic day 12.5 (more )
Note: Double labeled: green - Pdx1; red - Gluc (Gcg assay MGI:6382866).
Structure Level Pattern Image Note
TS20: pancreas Present 3B
Specimen 3F: embryonic day 12.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: green - Pdx1; red - Gluc (Gcg assay MGI:6382866).
Structure Level Pattern Image Note
TS20: pancreas Present 3F Authors report normal expression at E12.5.
Specimen 7C: embryonic day 15.5 (more )
Note: Double labeled: green - Pdx1; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS23: pancreas Present 7C
Specimen 7G: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: green - Pdx1; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS23: pancreas Weak 7G Number of expressing cells reduced compared with wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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