Rnf170 MGI Mouse Gene Detail - MGI:1924983

Symbol

Rnf170
Name

ring finger protein 170
Synonyms

6720407G21Rik

Feature Type

protein coding gene
IDs

MGI:1924983
NCBI Gene: 77733
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:26609396-26633903 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 14.38 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

557 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924983	protein coding gene	Chr8:26609396-26641818 (+)
129S1/SvImJ	ENSMUSG00200021355	protein coding gene	Chr8:21654213-21686422 (+)
A/J	ENSMUSG00195005194	protein coding gene	Chr8:22196160-22228369 (+)
AKR/J	ENSMUSG00220025460	protein coding gene	Chr8:21819748-21851957 (+)
BALB/cJ	ENSMUSG00180005362	protein coding gene	Chr8:21720743-21752952 (+)
C3H/HeJ	ENSMUSG00175006382	protein coding gene	Chr8:21783442-21815650 (+)
C57BL/6NJ	ENSMUSG00215011324	protein coding gene	Chr8:21694611-21727033 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030938	protein coding gene	Chr8:20598051-20621998 (+)
CAST/EiJ	ENSTCUG00005022890	protein coding gene	Chr8:21989357-22021502 (+)
CBA/J	ENSMUSG00210013284	protein coding gene	Chr8:21719972-21752180 (+)
DBA/2J	ENSMUSG00185037907	protein coding gene	Chr8:27520673-27552881 (+)
FVB/NJ	ENSMUSG00205003063	protein coding gene	Chr8:21218877-21251086 (+)
JF1/MsJ	ENSUMUG00000023451	protein coding gene	Chr8:29385325-29418983 (+)
LP/J	ENSMUSG00230012727	protein coding gene	Chr8:31280154-31312362 (+)
NOD/ShiLtJ	ENSMUSG00190004118	protein coding gene	Chr8:21753454-21785662 (+)
NZO/HlLtJ	ENSMUSG00225021462	protein coding gene	Chr8:34901510-34933717 (+)
PWK/PhJ	ENSLUMG00010025739	protein coding gene	Chr8:21768349-21801844 (+)
SPRET/EiJ	ENSMSPG00010016103	protein coding gene	Chr8:22046718-22077726 (+)
WSB/EiJ	ENSIUOG00005010802	protein coding gene	Chr8:22455366-22487575 (+)

Human Ortholog

RNF170, ring finger protein 170

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF170, ring finger protein 170
Synonyms

ADSA, SNAX1, SPG85
Links

HGNC:25358

NCBI Gene ID: 81790

UniProt: Q96K19
Chr Location

8p11.21; chr8:42849637-42897299 (-) GRCh38

MGI Vertebrate Homology

Rnf170 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF170
Gene Tree

Rnf170

Diseases

1 with Rnf170 mouse models; 2 with human RNF170 associations

Human Disease

Mouse Models

hereditary ataxia

IDs

View 1 model

autosomal dominant sensory ataxia 1

IDs

hereditary spastic paraplegia 85

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a null allele develop progressive gait abnormalities that are more pronounced in dark conditions with age.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

51

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf170

ZFIN rnf170

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All Sequences

76
RefSeq

12
UniProt

5
CCDS

CCDS22207.1, CCDS90380.1

Ensembl

ENSMUSG00000013878 (Evidence)
NCBI Gene

77733

			Length	Strain/Species	Flank
genomic	77733	NCBI Gene Model \| MGI Sequence Detail	24508	C57BL/6J	± kb
transcript	NM_001357294	RefSeq \| MGI Sequence Detail	4035	C57BL/6
polypeptide	Q8CBG9	UniProt \| EBI \| MGI Sequence Detail	286	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014104 E3 ubiquitin-protein ligase RNF170

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR010652 Domain of unknown function DUF1232

IPR038896 E3 ubiquitin-protein ligase RNF170

IPR018957 Zinc finger, C3HC4 RING-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic

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All nucleic 51

cDNA 51

Microarray probesets 5

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MGI:2142571

Summaries

All 36

Diseases 1

Gene Ontology 7

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:315640 Song X, et al., E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells. Cell Mol Immunol. 2020 Aug;17(8):865-874

TSS for Rnf170:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76735	Chr8:26609389-26609396 (+)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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