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Tgds Gene Detail
Summary
  • Symbol
    Tgds
  • Name
    TDP-glucose 4,6-dehydratase
  • Synonyms
    2610017J16Rik, 2610025M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923605
    NCBI Gene: 76355
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:118349323-118370167 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 61.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    954 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923605
 protein coding gene Chr14:118349323-118370177 (-)
129S1/SvImJ ENSMUSG00200024010
 protein coding gene Chr14:107213945-107235967 (-)
A/J ENSMUSG00195029612
 protein coding gene Chr14:106970030-106990876 (-)
AKR/J ENSMUSG00220007620
 protein coding gene Chr14:106763409-106784253 (-)
BALB/cJ ENSMUSG00180027202
 protein coding gene Chr14:106462061-106482899 (-)
C3H/HeJ ENSMUSG00175005668
 protein coding gene Chr14:108397819-108418665 (-)
C57BL/6NJ ENSMUSG00215020468
 protein coding gene Chr14:106614231-106635075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019591
 protein coding gene Chr14:107342636-107363473 (-)
CAST/EiJ ENSTCUG00005007036
 protein coding gene Chr14:108044006-108065710 (-)
CBA/J ENSMUSG00210026586
 protein coding gene Chr14:107366389-107387235 (-)
DBA/2J ENSMUSG00185013909
 protein coding gene Chr14:112522507-112543353 (-)
FVB/NJ ENSMUSG00205007117
 protein coding gene Chr14:106051691-106072518 (-)
JF1/MsJ ENSUMUG00000017185
 protein coding gene Chr14:123542103-123564131 (-)
LP/J ENSMUSG00230001767
 protein coding gene Chr14:124507768-124528609 (-)
NOD/ShiLtJ ENSMUSG00190020366
 protein coding gene Chr14:107171680-107192524 (-)
NZO/HlLtJ ENSMUSG00225028929
 protein coding gene Chr14:114529731-114550556 (-)
PWK/PhJ ENSLUMG00010028567
 protein coding gene Chr14:106431960-106453036 (-)
SPRET/EiJ ENSMSPG00010012149
 protein coding gene Chr14:110684936-110705055 (-)
WSB/EiJ ENSIUOG00005029657
 protein coding gene Chr14:106393755-106414590 (-)



Homology
more
  • Human Ortholog
    TGDS, TDP-glucose 4,6-dehydratase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGDS, TDP-glucose 4,6-dehydratase
  • Synonyms
    CATMANS, SDR2E1, TDPGD
  • Links
    NCBI Gene ID: 23483
    UniProt: O95455

  • Chr Location
    13q32.1; chr13:94574054-94596276 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tgds mouse models; 1 with human TGDS associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 4 alleles in 3 genetic backgrounds
    4 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit micrognathia and cleft palate. Mice homozygous for a knock-out allele exhibit embryonic growth retardation, abnormal head and forebrain shape, abnormal heart morphology associated with cardiac or pericardial edema and abnormal heart looping, abnormal yolk sacs, placentation defects, and complete lethality during organogenesis. A minority display incomplete embryo turning and branchial arch defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    111
  • cDNA Data
    36
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022130 Ensembl Gene Model | MGI Sequence Detail 20845 C57BL/6J ±  kb
    transcript ENSMUST00000022727 Ensembl | MGI Sequence Detail 1682 Not Applicable  
    polypeptide ENSMUSP00000022727 Ensembl | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 36
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917161, MGI:2145686
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory