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Casr Gene Detail
Summary
  • Symbol
    Casr
  • Name
    calcium-sensing receptor
  • Synonyms
    CaR, cation sensing receptor, Gprc2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351351
    NCBI Gene: 12374
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36314058-36382503 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 25.57 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1818 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351351
 protein coding gene Chr16:36310947-36382605 (-)
129S1/SvImJ ENSMUSG00200028777
 protein coding gene Chr16:33249582-33318019 (-)
A/J ENSMUSG00195011019
 protein coding gene Chr16:32801268-32869740 (-)
AKR/J ENSMUSG00220027403
 protein coding gene Chr16:33172869-33241239 (-)
BALB/cJ ENSMUSG00180012396
 protein coding gene Chr16:33016909-33085360 (-)
C3H/HeJ ENSMUSG00175030488
 protein coding gene Chr16:33237799-33305812 (-)
C57BL/6NJ ENSMUSG00215011976
 protein coding gene Chr16:33085159-33153608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020716
 protein coding gene Chr16:33534691-33607469 (-)
CAST/EiJ ENSTCUG00005029404
 protein coding gene Chr16:33502217-33570242 (-)
CBA/J ENSMUSG00210027501
 protein coding gene Chr16:33294895-33362901 (-)
DBA/2J ENSMUSG00185024362
 protein coding gene Chr16:33197900-33265918 (-)
FVB/NJ ENSMUSG00205014023
 protein coding gene Chr16:33149027-33217493 (-)
JF1/MsJ ENSUMUG00000035839
 protein coding gene Chr16:33412501-33480886 (-)
LP/J ENSMUSG00230024958
 protein coding gene Chr16:35769644-35838079 (-)
NOD/ShiLtJ ENSMUSG00190022846
 protein coding gene Chr16:33309772-33378210 (-)
NZO/HlLtJ ENSMUSG00225039253
 protein coding gene Chr16:38868997-38937456 (-)
PWK/PhJ ENSLUMG00010028505
 protein coding gene Chr16:33308611-33377026 (-)
SPRET/EiJ ENSMSPG00010016364
 protein coding gene Chr16:33298022-33322411 (-)
WSB/EiJ ENSIUOG00005024049
 protein coding gene Chr16:33360913-33429307 (-)



Homology
more
  • Human Ortholog
    CASR, calcium sensing receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CASR, calcium sensing receptor
  • Synonyms
    CAR, EIG8, FHH, FIH, GPRC2A, hCasR, HHC, HHC1, HYPOC1, NSHPT, PCAR1
  • Links
    NCBI Gene ID: 846
    UniProt: P41180

  • Chr Location
    3q13.33-q21.1; chr3:122183668-122291629 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Casr mouse models; 9 with human CASR associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 7 models
IDs
 View 6 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 10 alleles in 15 genetic backgrounds
    1 images
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit high levels of serum calcium and parathyroid hormone, parathyroid hyperplasia, bone defects, reduced growth, and early death. Carriers have elevated serum calcium, magnesium, and parathyroid hormone levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    124
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    101
  • cDNA Data
    7
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051980 Ensembl Gene Model | MGI Sequence Detail 68446 C57BL/6J ±  kb
    transcript ENSMUST00000172826 Ensembl | MGI Sequence Detail 3659 Not Applicable  
    polypeptide ENSMUSP00000133500 Ensembl | MGI Sequence Detail 1079 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005058 extracellular calcium-sensing receptor
      (term hierarchy)
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-related
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q9QY96 10 sites, 2 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 7
      Primer pair 8
      Other 1
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28074, MGI:104782
    References
    more
    • Summaries
      All 160
      Developmental Gene Expression 15
      Diseases 3
      Gene Ontology 13
      Phenotypes 78
    • Earliest
      J:43659 Pollak MR, et al., Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell. 1993 Dec 31;75(7):1297-303
    • Latest
      J:388185 Tu CL, et al., Amyloid-beta as a target to suppress tonic PTH hypersecretion in hyperparathyroidism due to vitamin D deficiency. Sci Transl Med. 2026 Mar 18;18(841):eadz2837
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory