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CasrBCH002
Chemically induced Allele Detail
Summary
Symbol: CasrBCH002
Name: calcium-sensing receptor; bone calcium high mutant 002
MGI ID: MGI:5424979
Gene: Casr  Location: Chr16:36314058-36382503 bp, - strand  Genetic Position: Chr16, 25.57 cM
Alliance: CasrBCH002 page
Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis ENU-induced mutation was isolated in a screen for metabolic bone disease as part of the Munich ENU Mutagenesis Project. Missense mutation in exon 7 of the gene; an T-to-A point mutation at position 2579 of the cDNA is predicted to alter codon 859 in the encoded protein from a isoleucine to asparagine. (J:183993)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casr Mutation:  59 strains or lines available
References
Original:  J:183993 Sabrautzki S, et al., New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 2012 Aug;23(7-8):416-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory