Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable several functions, including integrin binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Involved in regulation of presynaptic membrane potential. Acts upstream of or within positive regulation of gene expression and regulation of calcium ion transport. Is active in glutamatergic synapse. Is expressed in several structures, including branchial pouch; central nervous system; lung; metanephros; and superior cervical ganglion. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor).