Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables G protein-coupled receptor activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of NLRP3 inflammasome complex assembly; and regulation of presynaptic membrane potential. Acts upstream of or within positive regulation of ATP-dependent activity; positive regulation of gene expression; and regulation of calcium ion transport. Is active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including branchial pouch; central nervous system; gut gland; lung; and metanephros. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); intellectual disability; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor).

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Gene Ontology Evidence Code Abbreviations:

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