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Itm2b Gene Detail
Summary
  • Symbol
    Itm2b
  • Name
    integral membrane protein 2B
  • Synonyms
    Bri2, Bricd2b, D14Sel6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309517
    NCBI Gene: 16432
  • Alliance
    genome feature page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:73599666-73622729 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 38.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    589 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309517
 protein coding gene Chr14:73599666-73622729 (-)
129S1/SvImJ ENSMUSGG00200054783
 protein coding gene Chr14:62036435-62040198 (-)
129S1/SvImJ ENSMUSG00200009338
 protein coding gene Chr14:62051937-62056945 (-)
A/J ENSMUSGG00195055453
 protein coding gene Chr14:62171591-62175361 (-)
A/J ENSMUSG00195012965
 protein coding gene Chr14:62187127-62192132 (-)
AKR/J ENSMUSG00220007041
 protein coding gene Chr14:61496732-61501741 (-)
AKR/J ENSMUSGG00220054708
 protein coding gene Chr14:61481221-61484983 (-)
BALB/cJ ENSMUSGG00180055493
 protein coding gene Chr14:61778144-61781914 (-)
BALB/cJ ENSMUSG00180019785
 protein coding gene Chr14:61793680-61798685 (-)
C3H/HeJ ENSMUSG00175027649
 protein coding gene Chr14:63522755-63527764 (-)
C3H/HeJ ENSMUSGG00175054787
 protein coding gene Chr14:63507244-63511006 (-)
C57BL/6NJ ENSMUSGG00215055578
 protein coding gene Chr14:61753511-61757281 (-)
C57BL/6NJ ENSMUSG00215019582
 protein coding gene Chr14:61769047-61774052 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019501
 protein coding gene Chr14:64337697-64360629 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054887
 protein coding gene Chr14:62143732-62147494 (-)
CBA/J ENSMUSG00210009904
 protein coding gene Chr14:62159243-62164252 (-)
DBA/2J ENSMUSG00185021714
 protein coding gene Chr14:67308104-67313113 (-)
DBA/2J ENSMUSGG00185057398
 protein coding gene Chr14:67292593-67296355 (-)
FVB/NJ ENSMUSG00205019116
 protein coding gene Chr14:61611341-61616346 (-)
FVB/NJ ENSMUSGG00205054364
 protein coding gene Chr14:61595805-61599575 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055290
 protein coding gene Chr14:79386626-79390389 (-)
LP/J ENSMUSG00230012044
 protein coding gene Chr14:79402128-79407136 (-)
NOD/ShiLtJ ENSMUSG00190010230
 protein coding gene Chr14:61929805-61934814 (-)
NOD/ShiLtJ ENSMUSGG00190054869
 protein coding gene Chr14:61914294-61918056 (-)
NZO/HlLtJ ENSMUSG00225039468
 protein coding gene Chr14:69688199-69693204 (-)
NZO/HlLtJ ENSMUSGG00225055654
 protein coding gene Chr14:69672663-69676433 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ITM2B, integral membrane protein 2B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITM2B, integral membrane protein 2B
  • Synonyms
    ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, imBRI2, RDGCA
  • Links
    NCBI Gene ID: 9445
    UniProt: Q9Y287

  • Chr Location
    13q14.2; chr13:48232612-48270357 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Itm2b mouse models; 2 with human ITM2B associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display increased levels of soluble APP fragments in the brain. Mice homozygous for a knock-in allele exhibit impaired oject recognition, impaired contextual conditioning, and impaired spatial working memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    33
  • cDNA Data
    123
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16432 NCBI Gene Model | MGI Sequence Detail 23064 C57BL/6J ±  kb
    transcript NM_008410 RefSeq | MGI Sequence Detail 1796 ZRU/MplStud  
    polypeptide O89051 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 124

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-25792, MGI:104443, MGI:2145608
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
    • Latest
      J:365373 Wang Y, et al., A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease. J Hepatol. 2024 Dec 10;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory