Phenotypes Associated with This Genotype

Genotype
MGI:4936846

• Allelic Composition: Itm2b^tm1.1Ldad/Itm2b⁺
• Genetic Background: B6.129-Itm2b^tm1.1Ldad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:167154 )

abnormal object recognition memory ( J:167154 )

• mice spend equal time exploring novel and old objects unlike wild-type mice

impaired spatial working memory ( J:167154 )

• mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice

nervous system

reduced long-term potentiation ( J:167154 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:167154