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Lect2 Gene Detail
Summary
  • Symbol
    Lect2
  • Name
    leukocyte cell-derived chemotaxin 2
  • Synonyms
    chondromodulin-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278342
    NCBI Gene: 16841
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56690277-56696315 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278342
 protein coding gene Chr13:56676772-56696373 (-)
129S1/SvImJ ENSMUSG00200016307
 protein coding gene Chr13:53566256-53572294 (-)
A/J ENSMUSG00195040037
 protein coding gene Chr13:53032160-53038196 (-)
AKR/J ENSMUSG00220036603
 protein coding gene Chr13:52570899-52576937 (-)
BALB/cJ ENSMUSG00180014572
 protein coding gene Chr13:53277663-53283699 (-)
C3H/HeJ ENSMUSG00175037192
 protein coding gene Chr13:53063854-53069890 (-)
C57BL/6NJ ENSMUSG00215031780
 protein coding gene Chr13:53093004-53099042 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018587
 protein coding gene Chr13:51950235-51956474 (-)
CAST/EiJ ENSTCUG00005037281
 protein coding gene Chr13:53479038-53485199 (-)
CBA/J ENSMUSG00210031676
 protein coding gene Chr13:53268798-53274834 (-)
DBA/2J ENSMUSG00185014511
 protein coding gene Chr13:54117537-54123575 (-)
FVB/NJ ENSMUSG00205021471
 protein coding gene Chr13:52917508-52923546 (-)
JF1/MsJ ENSUMUG00000009416
 protein coding gene Chr13:53519137-53525217 (-)
LP/J ENSMUSG00230028250
 protein coding gene Chr13:63468012-63474048 (-)
NOD/ShiLtJ ENSMUSG00190022417
 protein coding gene Chr13:53169162-53175194 (-)
NZO/HlLtJ ENSMUSG00225032817
 protein coding gene Chr13:57189669-57195707 (-)
PWK/PhJ ENSLUMG00010020828
 protein coding gene Chr13:52404703-52410873 (-)
SPRET/EiJ ENSMSPG00010033294
 protein coding gene Chr13:52810319-52816435 (-)
WSB/EiJ ENSIUOG00005022062
 protein coding gene Chr13:52591057-52597091 (-)



Homology
more
  • Human Ortholog
    LECT2, leukocyte cell derived chemotaxin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LECT2, leukocyte cell derived chemotaxin 2
  • Synonyms
    chm2, chm-II
  • Links
    NCBI Gene ID: 3950
    UniProt: O14960

  • Chr Location
    5q31.1; chr5:135922279-135954983 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LECT2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display increased hepatic NKT cell numbers, increased induced cytokine secretion, and increased sensitivity to induced hepatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    3
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021539 Ensembl Gene Model | MGI Sequence Detail 6039 C57BL/6J ±  kb
    transcript ENSMUST00000062806 Ensembl | MGI Sequence Detail 837 Not Applicable  
    polypeptide ENSMUSP00000060495 Ensembl | MGI Sequence Detail 151 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 3
      cDNA 7
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:365815 Tanida R, et al., LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH. Endocrinology. 2024 May 27;165(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory