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Tyrobp Gene Detail
Summary
  • Symbol
    Tyrobp
  • Name
    TYRO protein tyrosine kinase binding protein
  • Synonyms
    DAP12, KARAP, killer cell activating receptor associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277211
    NCBI Gene: 22177
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30113207-30117007 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.45 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277211
 protein coding gene Chr7:30113185-30117010 (+)
129S1/SvImJ ENSMUSG00200041377
 protein coding gene Chr7:19885331-19889155 (+)
A/J ENSMUSG00195041585
 protein coding gene Chr7:22563521-22567361 (+)
AKR/J ENSMUSG00220049496
 protein coding gene Chr7:21914379-21918198 (-)
BALB/cJ ENSMUSG00180014963
 protein coding gene Chr7:20623001-20626843 (+)
C3H/HeJ ENSMUSG00175028248
 protein coding gene Chr7:21702203-21706030 (+)
C57BL/6NJ ENSMUSG00215053997
 protein coding gene Chr7:19804320-19808149 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029517
 protein coding gene Chr7:29652706-29656279 (+)
CAST/EiJ ENSTCUG00005042075
 protein coding gene Chr7:21601488-21605280 (+)
CBA/J ENSMUSG00210025136
 protein coding gene Chr7:20864811-20868636 (+)
DBA/2J ENSMUSG00185043445
 protein coding gene Chr7:23954161-23957999 (+)
FVB/NJ ENSMUSG00205014746
 protein coding gene Chr7:20613830-20617657 (+)
JF1/MsJ ENSUMUG00000054205
 protein coding gene Chr7:28399495-28403358 (+)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190007700
 protein coding gene Chr7:20287251-20291234 (+)
NZO/HlLtJ ENSMUSG00225026802
 protein coding gene Chr7:27964481-27968460 (+)
PWK/PhJ ENSLUMG00010020764
 protein coding gene Chr7:20331190-20334977 (+)
SPRET/EiJ ENSMSPG00010038697
 protein coding gene Chr7:19693417-19697420 (+)
WSB/EiJ ENSIUOG00005053314
 protein coding gene Chr7:14575090-14579066 (+)



Homology
more
  • Human Ortholog
    TYROBP, transmembrane immune signaling adaptor TYROBP
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYROBP, transmembrane immune signaling adaptor TYROBP
  • Synonyms
    DAP12, KARAP, PLOSL, PLOSL1
  • Links
    NCBI Gene ID: 7305
    UniProt: O43914

  • Chr Location
    19q13.12; chr19:35904401-35908301 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tyrobp mouse models; 1 with human TYROBP associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 4 alleles in 7 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    140 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit osteopetrosis, hypomyelination (especially of the thalamus), synaptic degeneration, and impaired oligodendrocyte, NK, and dendritic cell function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    620
  • Tissues
    14
  • cDNA Data
    21
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22177 NCBI Gene Model | MGI Sequence Detail 3801 C57BL/6J ±  kb
    transcript NM_011662 RefSeq | MGI Sequence Detail 592 ZRU/MplStud  
    polypeptide O54885 UniProt | EBI | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 21
      Other 2
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 232
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 28
      Phenotypes 140
    • Earliest
      J:49202 Lanier LL, et al., Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells [see comments]. Nature. 1998 Feb 12;391(6668):703-7
    • Latest
      J:375443 Etani H, et al., Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid beta fibrils. Alzheimers Res Ther. 2025 Nov 20;17(1):248
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory