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Targeted Allele Detail
Symbol: Tyrobptm1Ttk
Name: TYRO protein tyrosine kinase binding protein; targeted mutation 1, Toshiyuki Takai
MGI ID: MGI:2450834
Synonyms: DAP12-, DAP12KO, DAP12 KO, Tyrobp-
Gene: Tyrobp  Location: Chr7:30113207-30117007 bp, + strand  Genetic Position: Chr7, 17.45 cM, cytoband B
Alliance: Tyrobptm1Ttk page
Osteopetrosis in Tyrobptm1Ttk/Tyrobptm1Ttk mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:81823
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of the promoter region and exons 1-3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of lymphokine-activated killer (LAK) cell protein extracts. (J:81823)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyrobp Mutation:  10 strains or lines available
Original:  J:81823 Kaifu T, et al., Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest. 2003 Feb;111(3):323-32
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory