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Polr2m Gene Detail
Summary
  • Symbol
    Polr2m
  • Name
    polymerase (RNA) II (DNA directed) polypeptide M
  • Synonyms
    D9Wsu138e, Grinl1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:107282
    NCBI Gene: 28015
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:71385719-71393217 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107282
 protein coding gene Chr9:71385719-71393265 (-)
129S1/SvImJ ENSMUSG00200041937
 protein coding gene Chr9:68446317-68453815 (-)
A/J ENSMUSG00195025972
 protein coding gene Chr9:68235252-68242748 (-)
AKR/J ENSMUSG00220037642
 protein coding gene Chr9:68402070-68409568 (-)
BALB/cJ ENSMUSG00180015148
 protein coding gene Chr9:68349581-68357077 (-)
C3H/HeJ ENSMUSG00175011945
 protein coding gene Chr9:68362803-68370299 (-)
C57BL/6NJ ENSMUSG00215028517
 protein coding gene Chr9:68332490-68339988 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032411
 protein coding gene Chr9:68608083-68615739 (-)
CAST/EiJ ENSTCUG00005031230
 protein coding gene Chr9:68168701-68176208 (-)
CBA/J ENSMUSG00210013864
 protein coding gene Chr9:68443456-68450952 (-)
DBA/2J ENSMUSG00185033652
 protein coding gene Chr9:68467249-68474745 (-)
FVB/NJ ENSMUSG00205029235
 protein coding gene Chr9:68740580-68748077 (-)
JF1/MsJ ENSUMUG00000013536
 protein coding gene Chr9:68503265-68510776 (-)
LP/J ENSMUSG00230024757
 protein coding gene Chr9:68641357-68648855 (-)
NOD/ShiLtJ ENSMUSG00190019874
 protein coding gene Chr9:68571352-68578848 (-)
NZO/HlLtJ ENSMUSG00225045017
 protein coding gene Chr9:68775919-68783415 (-)
PWK/PhJ ENSLUMG00010023092
 protein coding gene Chr9:68433019-68440527 (-)
SPRET/EiJ ENSMSPG00010019899
 protein coding gene Chr9:69531732-69538836 (-)
WSB/EiJ ENSIUOG00005024963
 protein coding gene Chr9:67949446-67956944 (-)



Homology
more
  • Human Ortholog
    POLR2M, RNA polymerase II subunit M
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2M, RNA polymerase II subunit M
  • Synonyms
    Gdown, Gdown1, GRINL1A
  • Links
    NCBI Gene ID: 81488
    UniProt: P0CAP2, Q6EEV4

  • Chr Location
    15q21.3; chr15:57706695-57782762 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die in early embryogenesis. Liver specific deletion results in liver abnormalities and cell cycle anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    622
  • Tissues
    19
  • cDNA Data
    329
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032199 Ensembl Gene Model | MGI Sequence Detail 7499 C57BL/6J ±  kb
    transcript ENSMUST00000034720 Ensembl | MGI Sequence Detail 2200 Not Applicable  
    polypeptide ENSMUSP00000034720 Ensembl | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029509 DNA-directed RNA polymerase II subunit GRINL1A
      (term hierarchy)
    • InterPro Domains
      IPR026213 DNA-directed RNA polymerase II subunit GRINL1
      IPR051375 Tuftelin/GRINL1A/MYZAP/CCD68
    • GlyGen
      Q6P6I6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 332
      cDNA 330
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-35747, MGI:2142907, MGI:2142926, MGI:2143009, MGI:2143327
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:343970 Stavast CJ, et al., The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis. Leukemia. 2022 Mar;36(3):687-700
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory