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Serpine2 Gene Detail
Summary
  • Symbol
    Serpine2
  • Name
    serine (or cysteine) peptidase inhibitor, clade E, member 2
  • Synonyms
    B230326M24Rik, nexin, PI7, PN-1, protease nexin 1, Spi4
  • Feature Type
    protein coding gene
  • IDs
    MGI:101780
    NCBI Gene: 20720
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:79772038-79836382 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 40.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1927 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101780
 protein coding gene Chr1:79771914-79838897 (-)
129S1/SvImJ ENSMUSG00200035161
 protein coding gene Chr1:77449879-77516402 (-)
A/J ENSMUSG00195010024
 protein coding gene Chr1:76855819-76922808 (-)
AKR/J ENSMUSG00220010057
 protein coding gene Chr1:77027233-77094217 (-)
BALB/cJ ENSMUSG00180019617
 protein coding gene Chr1:77118338-77185320 (-)
C3H/HeJ ENSMUSG00175017800
 protein coding gene Chr1:77262339-77329324 (-)
C57BL/6NJ ENSMUSG00215018764
 protein coding gene Chr1:77167706-77234690 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014319
 protein coding gene Chr1:73115016-73180471 (-)
CAST/EiJ ENSTCUG00005024815
 protein coding gene Chr1:76828826-76894229 (-)
CBA/J ENSMUSG00210038651
 protein coding gene Chr1:77044598-77114663 (-)
DBA/2J ENSMUSG00185028784
 protein coding gene Chr1:78090749-78160819 (-)
FVB/NJ ENSMUSG00205036363
 protein coding gene Chr1:76575005-76645146 (-)
JF1/MsJ ENSUMUG00000001754
 protein coding gene Chr1:76892129-76957275 (-)
LP/J ENSMUSG00230008501
 protein coding gene Chr1:78025121-78091619 (-)
NOD/ShiLtJ ENSMUSG00190024745
 protein coding gene Chr1:77248238-77318297 (-)
NZO/HlLtJ ENSMUSG00225038426
 protein coding gene Chr1:81253443-81319916 (-)
PWK/PhJ ENSLUMG00010011734
 protein coding gene Chr1:76501204-76566415 (-)
SPRET/EiJ ENSMSPG00010018622
 protein coding gene Chr1:78666373-78731816 (-)
WSB/EiJ ENSIUOG00005013587
 protein coding gene Chr1:76788119-76858188 (-)



Homology
more
  • Human Ortholog
    SERPINE2, serpin family E member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINE2, serpin family E member 2
  • Synonyms
    GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
  • Links
    NCBI Gene ID: 5270
    UniProt: P07093

  • Chr Location
    2q36.1; chr2:223975045-224039688 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SERPINE2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation of this gene are viable and healthy but develop epileptic activity as well as reduced theta burst-induced LTP and NMDA receptor-mediated synaptic transmission in the CA1 field of the hippocampus; notably, homozygous mutant males are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1194
  • Tissues
    222
  • cDNA Data
    154
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20720 NCBI Gene Model | MGI Sequence Detail 64345 C57BL/6J ±  kb
    transcript NM_009255 RefSeq | MGI Sequence Detail 2071 ZRU/MplStud  
    polypeptide Q07235 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 166
      Genomic 1
      cDNA 160
      Primer pair 3
      Other 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18588, MGI:2443859
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 20
      Gene Ontology 19
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:378273 Xiao H, et al., Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea. Adv Sci (Weinh). 2025 May;12(18):e2412653
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory