Serpine2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
MGI:101780

24 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Serpine2^tm1Dmn/Serpine2^tm1Dmn B6.129P2-Serpine2^tm1Dmn	abnormal acute phase protein level	J:121263
	abnormal astrocyte morphology	J:121263
	abnormal cerebellar granule layer morphology	J:121263
	abnormal cerebellum external granule cell layer morphology	J:121263
	abnormal excitatory postsynaptic currents	J:94811
	abnormal motor capabilities/coordination/movement	J:94811
	abnormal response to injury	J:121223
	abnormal sciatic nerve morphology	J:121223
	abnormal sensory capabilities/reflexes/nociception	J:94811
	decreased Schwann cell number	J:121223
	delayed peripheral nervous system regeneration	J:121223
	increased cell proliferation	J:121263
	reduced NMDA receptor mediated synaptic activity in barrel cortex	J:94811
Serpine2^tm1Dmn/Serpine2^tm1Dmn involves: 129P2/OlaHsd * C57BL/6	abnormal copulatory plug biosynthesis	J:68075
	abnormal excitatory postsynaptic potential	J:40953
	abnormal prostate gland physiology	J:68075
	abnormal seminal vesicle epithelium morphology	J:68075
	abnormal seminal vesicle fluid composition	J:68075
	abnormal seminal vesicle morphology	J:68075
	dilated seminal vesicle	J:68075
	increased susceptibility to pharmacologically induced seizures	J:40953
	reduced long-term potentiation	J:40953
	reduced male fertility	J:68075
	normal reproductive system phenotype	J:68075

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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