74 phenotypes from 12 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm1(Notch3*)Sfr Notch3tm1.1(cre/ERT2)Sat/Notch3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	decreased mammary gland epithelial cell proliferation	J:201985
Notch3em1Ecan/Notch3+ C57BL/6J-Notch3em1Ecan	abnormal bone mineralization	J:270682
	abnormal bone trabecula morphology	J:270682
	abnormal osteoclast differentiation	J:270682
	normal behavior/neurological phenotype	J:270682
	decreased body weight	J:270682
	decreased bone mineral density	J:270682
	decreased bone trabecula number	J:270682
	decreased bone volume	J:270682
	decreased compact bone thickness	J:270682
	decreased trabecular bone connectivity density	J:270682
	decreased trabecular bone volume	J:270682
	increased bone ossification	J:270682
	increased osteoblast cell number	J:270682
	increased osteoblast proliferation	J:270682
	increased osteoclast cell number	J:270682
	increased osteocyte number	J:270682
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg involves: 129P2/OlaHsd	normal cardiovascular system phenotype	J:133358
	increased cerebral infarct size	J:133358
	increased susceptibility to induced morbidity/mortality	J:133358
	increased susceptibility to ischemic brain injury	J:133358
	normal nervous system phenotype	J:133358
Notch3hpbk/Notch3hpbk C57BL/6J-Notch3hpbk/GrsrJ	abnormal pregnancy	J:157222
	cachexia	J:157222
	hydrocephaly	J:157222
	impaired hearing	J:157222
	increased or absent threshold for auditory brainstem response	J:157222
	kyphosis	J:157222
	male infertility	J:157222
	myopathy	J:157222
	phimosis	J:157222
	premature death	J:157222
	skeletal muscle atrophy	J:157222
Notch3tm1.1(cre/ERT2)Sat/Notch3+ C57BL/6-Notch3tm1.1(cre/ERT2)Sat	no abnormal phenotype detected	J:179632
Notch3tm1.1(KOMP)Vlcg/Notch3tm1.1(KOMP)Vlcg C57BL/6N-Notch3tm1.1(KOMP)Vlcg/Ucd	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	decreased liver weight	J:211773
	decreased prepulse inhibition	J:211773
	enlarged heart	J:211773
	enlarged kidney	J:211773
	improved glucose tolerance	J:211773
	increased heart weight	J:211773
	increased kidney weight	J:211773
	increased neutrophil cell number	J:211773
	increased red blood cell distribution width	J:211773
	increased spleen weight	J:211773
Notch3tm1.1Dwr/Notch3+ involves: 129S/SvEv * Swiss	abnormal artery morphology	J:191454
	abnormal brain thrombosis	J:191454
	abnormal motor capabilities/coordination/movement	J:191454
	ataxia	J:191454
	brain lesion	J:191454
	normal cardiovascular system phenotype	J:191454
	decreased exploration in new environment	J:191454
	gliosis	J:191454
	paresis	J:191454
Notch3tm1.1Dwr/Notch3tm1.1Dwr involves: 129S/SvEv * Swiss	abnormal artery morphology	J:191454
	abnormal brain thrombosis	J:191454
	abnormal motor capabilities/coordination/movement	J:191454
	ataxia	J:191454
	brain lesion	J:191454
	normal cardiovascular system phenotype	J:191454
	decreased exploration in new environment	J:191454
	gliosis	J:191454
	paresis	J:191454
Notch3tm1Grid/Notch3tm1Grid 129S1/SvImJ-Notch3tm1Grid	no abnormal phenotype detected	J:87272
Notch3tm1Grid/Notch3tm1Grid involves: 129S1/Sv	abnormal artery morphology	J:94047
	abnormal blood circulation	J:94047
	abnormal vascular resistance	J:94047
	abnormal vascular smooth muscle morphology	J:94047
	poor arterial differentiation	J:94047
Notch3tm1Grid/Notch3tm1Grid involves: 129S1/Sv * C57BL/6	abnormal pericyte morphology	J:227333
	abnormal retina blood vessel morphology	J:227333
	abnormal vascular smooth muscle morphology	J:227333
Notch3tm1Grid/Notch3tm1Grid involves: 129S1/Sv * C57BL/6J	no abnormal phenotype detected	J:87272
Notch3tm1Khan/Notch3tm1Khan involves: C57BL/6 * CBA	decreased thymocyte number	J:98284
	small thymus	J:98284
Notch3tm1Ul/Notch3+ Not Specified	normal cardiovascular system phenotype	J:95927
	no abnormal phenotype detected	J:95927
Notch3tm1Ul/Notch3tm1Ul Not Specified	normal cardiovascular system phenotype	J:95927
	no abnormal phenotype detected	J:95927
Tg(Lck-Notch3)#Issc/0 involves: C57BL/6 * DBA/2	abnormal T cell differentiation	J:63300
	enlarged lymph nodes	J:63300
	enlarged spleen	J:63300
	hunched posture	J:63300
	increased acute lymphoblastic leukemia incidence	J:63300
	increased double-negative T cell number	J:63300
	increased lymphoblastic lymphoma incidence	J:63300
	increased T cell derived lymphoma incidence	J:96010
	increased thymocyte number	J:63300
	lethargy	J:63300
	premature death	J:63300, J:96010
	thymus hyperplasia	J:63300
Tg(Pdx1-Notch3)1Heed/? involves: C57BL/6 * CBA	abnormal pancreas development	J:57072