Gt(ROSA)26Sor^{tm1(Notch3*)Sfr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Notch3*)Sfr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Silvia Fre
• MGI ID: MGI:5556106
• Synonyms: R26-N3IC^SAT
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Notch3*)Sfr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201985
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Notch3*)Sfr} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch3 (MGI:99460)

• Mutation details: A floxed stop cassette followed by a cDNA fragment encoding the mouse Notch3 intracellular domain (amino acids 1668 to 2318), IRES and sequence for YFP were inserted into intron 1. The Notch3 fragment acts as a constitutively active receptor. (J:201985)

Schematic of the Gt(ROSA)26Sor^{tm1(Notch3*)Sfr} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:201985 Lafkas D, et al., Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J Cell Biol. 2013 Oct 14;203(1):47-56
• All: 2 reference(s)