Tgfbr1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tgfbr1
transforming growth factor, beta receptor I
MGI:98728

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Tgfbr1^tm1Bopa/Tgfbr1⁺ B6.Cg-Tgfbr1^tm1Bopa Apc^Min	increased gastrointestinal tumor incidence	J:143706
	increased intestinal adenocarcinoma incidence	J:143706
Apc^Min/Apc⁺ Tgfbr1^tm1Bopa/Tgfbr1⁺ involves: 129S1/SvImJ * C57BL/6J	normal hematopoietic system phenotype	J:143706
	increased cell proliferation	J:143706
	increased gastrointestinal tumor incidence	J:143706
	increased intestinal adenocarcinoma incidence	J:143706
Hprt1^{tm1(CAG-Tgfbr1)Lba}/Hprt1^{tm1(CAG-Tgfbr1)Lba} Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm Tg(Cd4-cre)1Cwi/0 involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2	normal immune system phenotype	J:148747
Hprt1^{tm1(CAG-Tgfbr1)Lba}/Y Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm Tg(Cd4-cre)1Cwi/0 involves: 129 129S6/SvEvTac * C57BL/6 * DBA/2	normal immune system phenotype	J:148747
Pten^tm1Hwu/Pten^tm1Hwu Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Tg(KRT14-cre/ERT)20Efu/0 involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N	abnormal anal canal morphology	J:209026
	increased oral papilloma incidence	J:194652
	increased organ/body region tumor incidence	J:209026
	increased papilloma incidence	J:194652
	increased squamous cell carcinoma incidence	J:194652, J:209026
Tg(Ela-KRASG12D)9Eps/0 Tgfbr1^tm1Bopa/Tgfbr1⁺ involves: 129S1/SvImJ C57BL/6 * FVB	abnormal pancreas physiology	J:231759
	increased CD8-positive, alpha-beta T cell number	J:231759
	increased pancreas tumor incidence	J:231759
Tg(Ela-KRASG12D)9Eps/0 Tgfbr1^tm1Bopa/Tgfbr1⁺ Tg(Mt1-TGFBR2)AM3Epb/0 involves: 129S1/SvImJ * C57BL/6 * FVB	decreased gland tumor incidence	J:231759
Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Tg(Tie1-cre)9Ref/? Gt(ROSA)26Sor^tm1Sor/? involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal visceral yolk sac morphology	J:128498
	abnormal vitelline vasculature morphology	J:128498
	absent vitelline blood vessels	J:128498
	embryonic growth retardation	J:128498
	embryonic lethality during organogenesis, complete penetrance	J:128498
	pericardial effusion	J:128498

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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