Pax8 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pax8
paired box 8
MGI:97492

63 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dicer1^tm1Smr/Dicer1^tm1Smr Pax8^{tm1.1(cre)Mbu}/Pax8⁺ involves: 129P2/OlaHsd * 129S7/SvEvBrd	abnormal kidney morphology	J:229188
	abnormal renal corpuscle morphology	J:229188
	abnormal renal glomerulus morphology	J:229188
	abnormal renal tubule epithelial cell primary cilium morphology	J:229188
	albuminuria	J:229188
	decreased body weight	J:229188
	decreased kidney collecting duct number	J:229188
	decreased kidney weight	J:229188
	decreased renal glomerular filtration rate	J:229188
	decreased urine osmolality	J:229188
	dilated renal glomerular capsule	J:229188
	dilated renal tubule	J:229188
	increased fluid intake	J:229188
	increased kidney apoptosis	J:229188
	increased kidney cell proliferation	J:229188
	increased urine protein level	J:229188
	isosthenuria	J:229188
	kidney cortex cyst	J:229188
	pale kidney	J:229188
	polyuria	J:229188
	renal interstitial fibrosis	J:229188
Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Pax8^{tm1.1(cre)Mbu}/Pax8⁺ involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal kidney collecting duct epithelium morphology	J:173125
	abnormal kidney medulla morphology	J:173125
	decreased urine creatinine level	J:173125
	decreased urine glucose level	J:173125
	decreased urine phosphate level	J:173125
	decreased urine potassium level	J:173125
	decreased urine protein level	J:173125
	decreased urine sodium level	J:173125
	elongated kidney papilla	J:173125
	hydronephrosis	J:173125
	increased kidney cell proliferation	J:173125
	increased urine calcium level	J:173125
	increased urine chloride ion level	J:173125
	oliguria	J:173125
Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg Pax8^{tm1.1(cre)Mbu}/Pax8⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal urine homeostasis	J:197393
	decreased urine ammonia level	J:197393
	decreased urine pH	J:197393
	increased urine potassium level	J:197393
	metabolic acidosis	J:197393
	normal mortality/aging	J:197393
	polyuria	J:197393
	normal renal/urinary system phenotype	J:197393
Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg Ugcg^tm1Hjg/Ugcg^tm1Hjg Pax8^{tm1.1(cre)Mbu}/Pax8⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal kidney papilla morphology	J:197393
	abnormal urine homeostasis	J:197393
	decreased urine ammonia level	J:197393
	decreased urine pH	J:197393
	normal homeostasis/metabolism phenotype	J:197393
	increased urine potassium level	J:197393
	normal mortality/aging	J:197393
	polyuria	J:197393
	normal renal/urinary system phenotype	J:197393
Hnrnpf^tm1Jsdc/Hnrnpf^tm1Jsdc Pax8^{tm1.1(cre)Mbu}/Pax8⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal proximal convoluted tubule morphology	J:284239
	abnormal renal tubule morphology	J:284239
	abnormal urine homeostasis	J:284239
	albuminuria	J:284239
	hypertension	J:284239
	increased angiotensin II level	J:284239
	increased systemic arterial systolic blood pressure	J:284239
	increased urine glucose level	J:284239
	polyuria	J:284239
	renal interstitial fibrosis	J:284239
Pax2^tm1Mbu/Pax2⁺ Pax8^tm1(cre)Mbu/Pax8⁺ involves: 129P2/OlaHsd * C3H/He * C57BL/6	abnormal metanephric mesenchyme morphology	J:80208
	blind vagina	J:80208
	decreased nephron number	J:80208
	decreased renal glomerulus number	J:80208
	reduced male fertility	J:80208
	renal hypoplasia	J:80208
	small metanephros	J:80208
	vagina atresia	J:80208
Pax2^tm1Mbu/Pax2⁺ Pax8^tm1(cre)Mbu/Pax8^tm1(cre)Mbu involves: 129P2/OlaHsd * C3H/He * C57BL/6	absent metanephros	J:80208
	absent ureter	J:80208
	absent vas deferens	J:80208
Pax2^tm1Mbu/Pax2^tm1Mbu Pax8^tm1(cre)Mbu/Pax8^tm1(cre)Mbu C3.Cg-Pax2^tm1Mbu Pax8^tm1(cre)Mbu	abnormal kidney development	J:80208
Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Plxnb1^tm1Rkun/Plxnb1^tm1Rkun Plxnb2^tm1.1Rkun/Plxnb2^tm1.1Rkun involves: 129P2/OlaHsd * C57BL/6	abnormal renal tubule epithelium morphology	J:221423
Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Plxnb2^tm1.1Rkun/Plxnb2^tm1.1Rkun involves: 129P2/OlaHsd * C57BL/6	abnormal renal tubule epithelium morphology	J:221423
	increased susceptibility to kidney reperfusion injury	J:221423
Ugcg^tm1Hjg/Ugcg^tm1Hjg Pax8^{tm1.1(cre)Mbu}/Pax8⁺ involves: 129P2/OlaHsd * C57BL/6	decreased urine pH	J:197393
	normal mortality/aging	J:197393
	normal renal/urinary system phenotype	J:197393

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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