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Pax8tm1(cre)Mbu
Targeted Allele Detail
Summary
Symbol: Pax8tm1(cre)Mbu
Name: paired box 8; targeted mutation 1, Meinrad Busslinger
MGI ID: MGI:2445461
Synonyms: Pax8-, Pax8neo
Gene: Pax8  Location: Chr2:24310572-24365611 bp, - strand  Genetic Position: Chr2, 16.43 cM, cytoband B
Alliance: Pax8tm1(cre)Mbu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80208
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Pax8tm1(cre)Mbu expression driven by 1 gene
 
Mutation detailsThe gene was disrupted by replacement of exon 3 with an in-frame cre recombinase and frt-flanked neo cassette via homologous recombination. The targeted mutation deletes the N-terminal portion of the paired domain, which is essential for DNA-binding. (J:80208)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pax8 (mouse)
Summary of all recombinase alleles driven by Pax8.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax8 Mutation:  32 strains or lines available
References
Original:  J:80208 Bouchard M, et al., Nephric lineage specification by Pax2 and Pax8. Genes Dev. 2002 Nov 15;16(22):2958-70
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory