Pax8^{tm1.1(cre)Mbu}
Targeted Allele Detail

Summary

• Symbol: Pax8^{tm1.1(cre)Mbu}
• Name: paired box 8; targeted mutation 1.1, Meinrad Busslinger
• MGI ID: MGI:3050216
• Synonyms: Pax8^cre
• Gene: Pax8 Location: Chr2:24310572-24365611 bp, - strand Genetic Position: Chr2, 16.43 cM, cytoband B
• Alliance: Pax8^{tm1.1(cre)Mbu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89762
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Pax8^{tm1.1(cre)Mbu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax8 (MGI:97492)

• Mutation details: Crossing Pax8^tm1(cre)Mbu with mice expressing FLP recombinase in the germline created this allele in which the frt-flanked neo downstream of the inserted Cre was excised, allowing Cre to be expressed. Expression of cre recombinase was detected in the known Pax8 expression domains; in addition, expression was detected in the adrenal gland, and in the facial, vestibulocochlear and cuneate nerves. (J:89762)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax8 (mouse) Summary of all recombinase alleles driven by Pax8. Alliance mouse Pax8 gene page

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax8 Mutation: 32 strains or lines available

References

• Original: J:89762 Bouchard M, et al., Tissue-specific expression of cre recombinase from the Pax8 locus. Genesis. 2004 Mar;38(3):105-9
• All: 43 reference(s)