233 phenotypes from 11 alleles in 19 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nos3em1(IMPC)Mbp/Nos3em1(IMPC)Mbp C57BL/6N-Nos3em1(IMPC)Mbp/Ucd	abnormal epididymis morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal lymph node morphology	J:211773
	abnormal spleen morphology	J:211773
	decreased circulating phosphate level	J:211773
	decreased fasting circulating glucose level	J:211773
	decreased lymphocyte cell number	J:211773
	enlarged epididymis	J:211773
	enlarged lymph nodes	J:211773
	enlarged spleen	J:211773
	increased basophil cell number	J:211773
	increased blood urea nitrogen level	J:211773
	increased eosinophil cell number	J:211773
	increased heart weight	J:211773
	increased neutrophil cell number	J:211773
	small kidney	J:211773
Nos3m1Btlr/Nos3m1Btlr C57BL/6J-Nos3m1Btlr	increased susceptibility to induced colitis	J:225268
	increased susceptibility to weight loss	J:225268
Nos3M2Btlr/Nos3M2Btlr C57BL/6J-Nos3M2Btlr	increased susceptibility to induced colitis	J:272392
Nos3tm1.1Taka/Nos3tm1.1Taka involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	no abnormal phenotype detected	J:187860
Nos3tm1.2Taka/Nos3tm1.2Taka involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA	abnormal renal glomerulus morphology	J:187860
	decreased heart rate	J:187860
	decreased kidney weight	J:187860
	increased circulating glucose level	J:187860
	increased circulating triglyceride level	J:187860
	increased mean systemic arterial blood pressure	J:187860
	increased systemic arterial systolic blood pressure	J:187860
Nos3tm1Gdk/Nos3tm1Gdk B6.129P2-Nos3tm1Gdk	abnormal dopamine level	J:64214
	abnormal learning/memory/conditioning	J:64214
	abnormal serotonin level	J:64214
	abnormal spatial learning	J:64214
	decreased locomotor activity	J:64214
	enhanced long-term object recognition memory	J:64214
	increased anxiety-related response	J:64214
Nos3tm1Gdk/Nos3tm1Gdk involves: 129P2/OlaHsd * C57BL/6	decreased heart rate	J:46061
	hypertension	J:46061
	increased vasoconstriction	J:46061
Nos3tm1Plh/Nos3+ involves: 129S4/SvJae * C57BL/6	abnormal pulmonary alveolus morphology	J:83896
Nos3tm1Plh/Nos3tm1Plh B6.129S4-Nos3tm1Plh	abnormal cerebral blood flow rate	J:107964
	abnormal circulating glucose level	J:155090
	abnormal induced retina neovascularization	J:106207
	abnormal nervous system physiology	J:107964
	abnormal seizure response to inducing agent	J:107964
	abnormal systemic arterial blood pressure	J:107964
	abnormal vascular endothelial cell physiology	J:155090
	normal cardiovascular system phenotype	J:106207
	decreased adiponectin level	J:155090
	hypertension	J:155090
	increased circulating triglyceride level	J:155090
	increased white adipose tissue amount	J:155090
Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae	abnormal blood flow velocity	J:112419
	abnormal ejaculation	J:59686
	abnormal heart right ventricle pressure	J:57624, J:100308
	abnormal leukocyte adhesion	J:55936
	abnormal neutrophil physiology	J:55936
	abnormal penile erection	J:89704
	abnormal pulmonary pressure	J:57624
	abnormal pulmonary vascular resistance	J:112419
	abnormal response/metabolism to endogenous compounds	J:112419
	abnormal systemic arterial blood pressure	J:112419
	abnormal systemic vascular resistance	J:112419
	abnormal vasodilation	J:112419
	decreased coronary flow rate	J:60525
	decreased heart rate	J:60525, J:100308
	decreased neurotransmitter release	J:119052
	decreased survivor rate	J:100308
	decreased vasodilation	J:28778
	enhanced leukocyte tethering or rolling	J:55936
	hypertension	J:28778, J:60525
	increased heart rate	J:112419
	increased mean systemic arterial blood pressure	J:55936
	increased susceptibility to neuronal excitotoxicity	J:111644
	increased systemic arterial blood pressure	J:57624
	increased vasoconstriction	J:57624
	insulin resistance	J:62229
	normal muscle phenotype	J:56948
	normal nervous system phenotype	J:37956
	premature death	J:100308
	pulmonary hypertension	J:112419
Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * C57BL/6	abnormal adipose tissue amount	J:133437
	abnormal associative learning	J:101302
	abnormal blood vessel physiology	J:75645, J:108540
	abnormal bone mineralization	J:67336
	abnormal dentate gyrus morphology	J:101302
	abnormal eye physiology	J:66540
	abnormal female meiosis	J:89702
	abnormal femur morphology	J:67336
	abnormal heart left ventricle morphology	J:75645
	abnormal hepatocyte morphology	J:133437
	abnormal induced retina neovascularization	J:66540
	abnormal liver morphology	J:133437
	abnormal liver physiology	J:133437
	abnormal long bone epiphyseal plate morphology	J:67336
	abnormal lung vasculature morphology	J:83896
	abnormal myocardial fiber physiology	J:75645
	abnormal neuron morphology	J:101302
	abnormal neuronal precursor proliferation	J:101302
	abnormal oocyte morphology	J:89702
	abnormal oogenesis	J:89702
	abnormal osteoblast physiology	J:67336
	abnormal ovary physiology	J:89702
	abnormal primary polar body morphology	J:89702
	abnormal pulmonary alveolus morphology	J:83896
	abnormal renal glomerulus morphology	J:67336
	abnormal superovulation	J:58361
	abnormal trabecular bone thickness	J:67336
	abnormal vascular wound healing	J:119617, J:139343
	decreased body weight	J:83896
	decreased bone mineral density	J:67336
	decreased cardiac muscle contractility	J:75645
	decreased circulating glucose level	J:133437
	decreased circulating insulin level	J:133437
	decreased litter size	J:58361, J:89702
	decreased physiological sensitivity to xenobiotic	J:108540
	decreased prostaglandin level	J:108540
	decreased superovulation rate	J:89702
	heart left ventricle hypertrophy	J:75645
	hepatic steatosis	J:133437
	normal homeostasis/metabolism phenotype	J:133437
	increased body weight	J:133437
	increased cardiac muscle contractility	J:75645
	increased circulating estradiol level	J:89702
	increased heart rate	J:75645
	increased susceptibility to bacterial infection	J:105005
	increased susceptibility to bacterial infection induced morbidity/mortality	J:105005
	increased systemic arterial systolic blood pressure	J:75645, J:108540
	maternal effect	J:89702
	reduced female fertility	J:89702
	short estrous cycle	J:58361
	short femur	J:67336
	small ovary	J:89702
Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * C57BL/6J	decreased ovulation rate	J:89542
	normal digestive/alimentary phenotype	J:64225
	increased circulating estradiol level	J:89542
	increased circulating progesterone level	J:89542
	prolonged diestrus	J:89542
	prolonged estrous cycle	J:89542
Nos3tm1Unc/Nos3+ B6.129P2-Nos3tm1Unc/J	postnatal lethality, incomplete penetrance	J:103270
Nos3tm1Unc/Nos3+ involves: 129P2/OlaHsd * C57BL/6J	increased vasodilation	J:54772
Nos3tm1Unc/Nos3tm1Unc B6.129P2-Nos3tm1Unc	abnormal blood-brain barrier function	J:150557
Nos3tm1Unc/Nos3tm1Unc B6.129P2-Nos3tm1Unc/J	abnormal angiogenesis	J:98913
	abnormal circulating protein level	J:129477
	abnormal glomerular capillary endothelium morphology	J:148626
	abnormal glomerular capillary thrombosis	J:148626
	abnormal heart morphology	J:103270
	abnormal interventricular septum membranous part morphology	J:103270
	abnormal kidney cortex morphology	J:148626
	abnormal kidney morphology	J:117046
	abnormal lung morphology	J:98913
	abnormal lung vasculature morphology	J:98913
	abnormal osteoblast physiology	J:129477
	abnormal osteoclast physiology	J:129477
	abnormal ovary morphology	J:145649
	abnormal pregnancy	J:145649
	abnormal proximal convoluted tubule morphology	J:117046
	abnormal redox activity	J:98094
	abnormal renal glomerulus morphology	J:117046
	abnormal renal tubule epithelium morphology	J:148626
	abnormal surfactant secretion	J:103340
	abnormal systemic arterial blood pressure	J:148626
	abnormal type II pneumocyte morphology	J:98913
	abnormal vascular branching morphogenesis	J:98913
	absent alveolar lamellar bodies	J:98913
	albuminuria	J:148626
	anovulation	J:145649
	bicuspid aortic valve	J:103340
	cardiac hypertrophy	J:98094
	cyanosis	J:98913
	decreased bone mineral density	J:129477
	decreased cardiac muscle contractility	J:103270
	decreased corpora lutea number	J:145649
	decreased fertilization frequency	J:145649
	decreased kidney cell proliferation	J:148626
	decreased ovulation rate	J:145649
	decreased vascular endothelial cell number	J:148626
	dilated renal glomerular capsule	J:117046
	dilated renal tubule	J:148626
	enlarged heart	J:103270
	expanded mesangial matrix	J:148626
	fetal growth retardation	J:98913, J:140819
	glomerulosclerosis	J:117046, J:148626
	impaired embryo implantation	J:145649
	increased blood urea nitrogen level	J:148626
	increased bone mineral density	J:129477
	increased circulating creatine kinase level	J:148626
	increased circulating osteocalcin level	J:129477
	increased compact bone thickness	J:129477
	increased fetal cardiomyocyte apoptosis	J:103270
	increased heart atrium size	J:103270
	increased heart left ventricle size	J:103270
	increased heart right ventricle size	J:103270
	increased heart ventricle size	J:103270
	increased inflammatory response	J:103018
	increased kidney apoptosis	J:148626
	increased left ventricle systolic pressure	J:98094
	increased mesangial cell number	J:148626
	increased renal tubule apoptosis	J:117046
	increased susceptibility to induced aneurysm formation	J:148626
	increased ventricle muscle contractility	J:98094
	kidney degeneration	J:117046
	kidney failure	J:148626
	kidney inflammation	J:148626
	lung hemorrhage	J:98913
	mesangiolysis	J:148626
muscular ventricular septal defect	J:103270
neonatal lethality, incomplete penetrance	J:98913
ostium secundum atrial septal defect	J:103270
postnatal lethality, incomplete penetrance	J:103270
pulmonary alveolar edema	J:103270
pulmonary vascular congestion	J:103270
renal cast	J:148626
renal glomerulus fibrosis	J:148626
renal glomerulus hypertrophy	J:148626
renal glomerulus lipidosis	J:117046
renal hypoplasia	J:117046
renal interstitial fibrosis	J:117046, J:148626
renal tubular necrosis	J:117046
respiratory distress	J:98913
small ovary	J:145649
thick pulmonary interalveolar septum	J:98913
ventricular septal defect	J:103270
Nos3tm1Unc/Nos3tm1Unc BKS.129P2-Nos3tm1Unc	albuminuria	J:135864
	increased systemic arterial systolic blood pressure	J:135864
Nos3tm1Unc/Nos3tm1Unc involves: 129P2/OlaHsd	abnormal blood homeostasis	J:103153
	abnormal glucose homeostasis	J:103153
	abnormal heart morphology	J:102136
	abnormal interventricular septum morphology	J:102136
	abnormal systemic arterial blood pressure	J:102136
	cardiac hypertrophy	J:102136
	decreased body weight	J:102136
	decreased cardiac muscle contractility	J:102136
	decreased heart left ventricle posterior wall thickness	J:102136
	decreased vasodilation	J:103153
	dilated heart left ventricle	J:102136
	hyperlipidemia	J:103153
	hypertension	J:102136, J:103153
	increased circulating cholesterol level	J:103153
	increased circulating free fatty acids level	J:103153
	increased circulating insulin level	J:103153
	increased circulating triglyceride level	J:103153
	increased heart rate	J:102136
	increased heart weight	J:102136
	increased systemic arterial blood pressure	J:102136
	increased systemic arterial diastolic blood pressure	J:102136
	increased systemic arterial systolic blood pressure	J:102136
	insulin resistance	J:103153
	premature death	J:102136
Nos3tm1Unc/Nos3tm1Unc involves: 129P2/OlaHsd * C57BL/6	abnormal cardiovascular system morphology	J:101254
	abnormal cardiovascular system physiology	J:101254
	abnormal heart right ventricle pressure	J:101254
	abnormal heart weight	J:101254
	abnormal pulmonary artery morphology	J:101254
	decreased body temperature	J:113106
	decreased body weight	J:36559, J:101254
	decreased heart rate	J:36559
	decreased susceptibility to induced morbidity/mortality	J:113106
	decreased vascular permeability	J:113106
	normal immune system phenotype	J:36559
	increased circulating renin level	J:36559
	increased mean systemic arterial blood pressure	J:101254
	increased systemic arterial blood pressure	J:36559
Nos3tm1Unc/Nos3tm1Unc involves: 129P2/OlaHsd * C57BL/6J	abnormal vasodilation	J:54772
	decreased body weight	J:36559
	decreased heart rate	J:36559, J:54772
	normal homeostasis/metabolism phenotype	J:64896
	hypertension	J:54772
	increased circulating renin level	J:36559
	increased systemic arterial blood pressure	J:36559
	increased vasoconstriction	J:54772
Nos3tm1Weo/Nos3tm1Weo B6.129S7-Nos3tm1Weo	abnormal fertility/fecundity	J:89703
	abnormal superovulation	J:89703
	decreased superovulation rate	J:73964, J:89703
	delayed female fertility	J:89703
	early reproductive senescence	J:89703
	impaired fertilization	J:73964
Nos3tm1Weo/Nos3tm1Weo involves: 129	normal reproductive system phenotype	J:73964
Nos3tm1Weo/Nos3tm1Weo involves: 129S7/SvEvBrd * C57BL/6	abnormal cardiac muscle relaxation	J:51563
	abnormal limb morphology	J:51563
	postnatal lethality, incomplete penetrance	J:51563
	short limbs	J:51563
	syndactyly	J:51563
Nos3tm2.1Plh/Nos3tm2.1Plh involves: 129S4/SvJae * C57BL/6	decreased adiponectin level	J:198075
	decreased circulating insulin level	J:198075
	decreased vasodilation	J:198075
	increased brown adipose tissue amount	J:198075
	increased circulating free fatty acids level	J:198075
	increased circulating LDL cholesterol level	J:198075
	increased circulating leptin level	J:198075
	increased inguinal fat pad weight	J:198075
	increased liver weight	J:198075
	increased mean systemic arterial blood pressure	J:198075
	increased retroperitoneal fat pad weight	J:198075
	increased susceptibility to weight gain	J:198075
	increased white fat cell size	J:198075
	insulin resistance	J:198075
Nos3tm3.1Plh/Nos3tm3.1Plh involves: 129S4/SvJae * C57BL/6	decreased white fat cell size	J:198075
	improved glucose tolerance	J:198075
	increased circulating glucose level	J:198075
	increased circulating insulin level	J:198075